TRAF3IP2

Description		TRAF3 interacting protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle
	Molecular Function	Signaling Receptor Binding Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Establishment Of T Cell Polarity B Cell Homeostasis B Cell Apoptotic Process Kidney Development Positive Regulation Of Defense Response To Virus By Host Leukocyte Activation Involved In Inflammatory Response Transitional Two Stage B Cell Differentiation B Cell Affinity Maturation Eosinophil Mediated Immunity Protein Import Into Nucleus Inflammatory Response Immune Response Humoral Immune Response Heart Development Response To Xenobiotic Stimulus Gene Expression Protein Ubiquitination Cytokine-mediated Signaling Pathway B Cell Mediated Immunity Signal Transduction Involved In Regulation Of Gene Expression CD40 Signaling Pathway T Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Response To Cytokine Protein Localization To Nucleus Intracellular Signal Transduction Interleukin-17A-mediated Signaling Pathway Type 2 Immune Response T Cell Activation Neutrophil Activation Positive Regulation Of Canonical NF-kappaB Signal Transduction Skin Development MRNA Stabilization Lymph Node Development Spleen Development Mucus Secretion Protein K63-linked Ubiquitination Cellular Response To Cytokine Stimulus T-helper 17 Type Immune Response Cellular Response To Interleukin-17 Interleukin-17-mediated Signaling Pathway Protein Localization To P-body Negative Regulation Of Interleukin-17-mediated Signaling Pathway Eosinophil Homeostasis
Pathways
Drugs
Diseases
GWAS		Dental caries (decayed and filled deciduous tooth surfaces) ( 31533690) Inflammatory bowel disease ( 23128233 28067908) Inflammatory skin disease ( 25574825) Intraocular pressure ( 29617998) Psoriasis ( 20953188 20953190 23143594 25574825 25903422) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 20953186 26626624) Refractive error ( 32231278) Smoking status (ever vs never smokers) ( 30643258) Ulcerative colitis ( 28067908)
Interacting Genes		23 interacting genes: CD40 CHUK FHL3 GOLGA2 HSD17B10 IKBKB IKBKG MAP3K7 MDFI MRPL28 RIMBP3 STK16 TBK1 TRAF1 TRAF2 TRAF3 TRAF5 TRAF6 TRIM55 TRIM63 TRIP6 UBC UBE2V1
Entrez ID		10758
HPRD ID		06129
Ensembl ID		ENSG00000056972
Uniprot IDs		O43734
PDB IDs
Enriched GO Terms of Interacting Partners?		CD40 Receptor Complex Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Canonical NF-kappaB Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of DNA-binding Transcription Factor Activity CD40 Signaling Pathway Non-canonical NF-kappaB Signal Transduction Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Tumor Necrosis Factor Receptor Binding Thioesterase Binding TRIF-dependent Toll-like Receptor Signaling Pathway Signaling Adaptor Activity Signal Transduction Involved In Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Regulation Of Intracellular Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Ubiquitin Protein Ligase Binding Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cytoplasmic Side Of Plasma Membrane Cell Surface Pattern Recognition Receptor Signaling Pathway Defense Response To Other Organism Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Response To Other Organism Pattern Recognition Receptor Signaling Pathway Innate Immune Response IkappaB Kinase Complex Positive Regulation Of Immune Response Immune Response Innate Immune Response-activating Signaling Pathway Positive Regulation Of Type I Interferon Production Positive Regulation Of Signal Transduction Activation Of Innate Immune Response Defense Response To Symbiont Interleukin-17-mediated Signaling Pathway Response To External Biotic Stimulus Immune Response-activating Signaling Pathway Transferrin Receptor Binding Defense Response Positive Regulation Of JUN Kinase Activity Toll-like Receptor Signaling Pathway Response To Virus Regulation Of Signal Transduction Identical Protein Binding
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