CATSPER1 and APOA2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		CATSPER1	APOA2
Gene Name		cation channel, sperm associated 1	apolipoprotein A-II
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Motile Cilium CatSper Complex	Extracellular Region Early Endosome Endoplasmic Reticulum Lumen Cytosol Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Chylomicron Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Calcium Activated Cation Channel Activity Voltage-gated Calcium Channel Activity Protein Binding	Lipid Transporter Activity Protein Binding Phospholipid Binding High-density Lipoprotein Particle Binding Lipid Binding Cholesterol Binding Cholesterol Transporter Activity Phosphatidylcholine Binding Apolipoprotein Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Lipase Inhibitor Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity High-density Lipoprotein Particle Receptor Binding
	Biological Process	Multicellular Organismal Development Spermatogenesis Single Fertilization Fusion Of Sperm To Egg Plasma Membrane Cell Differentiation Sperm Motility Multicellular Organism Reproduction Regulation Of Ion Transmembrane Transport Sperm-egg Recognition Regulation Of Calcium Ion Transport Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Calcium Ion Import Calcium Ion Transmembrane Transport Membrane Depolarization During Action Potential	Retinoid Metabolic Process Acute Inflammatory Response Negative Regulation Of Cytokine Secretion Involved In Immune Response Protein Folding Triglyceride Metabolic Process Phosphatidylcholine Biosynthetic Process Phototransduction, Visible Light Cholesterol Metabolic Process Phospholipid Catabolic Process Response To Glucose Positive Regulation Of Cholesterol Esterification Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Viral Process Protein Oxidation Peptidyl-methionine Modification Regulation Of Intestinal Cholesterol Absorption Organ Regeneration Regulation Of Protein Stability Negative Regulation Of Cholesterol Transport Cholesterol Efflux Phospholipid Efflux Triglyceride-rich Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly High-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Response To Drug Cholesterol Homeostasis Positive Regulation Of Catalytic Activity Response To Estrogen Reverse Cholesterol Transport Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Diacylglycerol Catabolic Process Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Catabolic Process Response To Glucocorticoid Negative Regulation Of Lipase Activity Negative Regulation Of Cholesterol Import Negative Regulation Of Cholesterol Transporter Activity
Pathways		Sperm Motility And Taxes Fertilization	Lipoprotein metabolism PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Visual phototransduction Metabolism of lipids and lipoproteins Chylomicron-mediated lipid transport Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Lipid digestion, mobilization, and transport Diseases associated with visual transduction Retinoid metabolism and transport
Drugs
Diseases
GWAS
Protein-Protein Interactions		33 interactors: ADAMTSL4 AGR2 APOA2 BEGAIN CHIC2 CHRD EFEMP2 EMD KHDRBS2 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 MDFI MTUS2 NOTCH2NL PLSCR1 PLSCR3 RFX6 RGS20 RIMBP3 SCRG1 SPRY2 TRAF2 TRIP6	11 interactors: ABCA13 APOA1 APOA1BP APOC1 APOD APOF C4A CATSPER1 PLTP SCARB1 VKORC1
Entrez ID		117144	336
HPRD ID		09396	00129
Ensembl ID		ENSG00000175294	ENSG00000158874
Uniprot IDs		Q8NEC5	P02652
PDB IDs			1L6L 2OU1
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Transport Regulation Of Establishment Of Protein Localization Phospholipid Scrambling Regulation Of Protein Localization Phospholipid Transport Regulation Of Cellular Localization Regulation Of Protein Import Into Nucleus Negative Regulation Of Protein Transport Regulation Of Signaling Regulation Of Protein Localization To Nucleus Glandular Epithelial Cell Differentiation Regulation Of Nucleocytoplasmic Transport BMP Signaling Pathway Involved In Spinal Cord Dorsal/ventral Patterning Pancreatic Epsilon Cell Differentiation Negative Regulation Of Cholesterol Transporter Activity Pancreatic D Cell Differentiation I-kappaB Kinase/NF-kappaB Signaling Regulation Of Intracellular Protein Transport Positive Regulation Of Catalytic Activity Regulation Of Signal Transduction Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of JUN Kinase Activity Regulation Of Membrane Lipid Distribution Negative Regulation Of Protein Import Into Nucleus Mucus Secretion Regulation Of Cholesterol Transporter Activity Negative Regulation Of Cholesterol Import Acute Inflammatory Response Regulation Of MAP Kinase Activity Regulation Of Cytokine Production Involved In Immune Response Epithelium Development Cholesterol Homeostasis Lipid Transport Sterol Homeostasis Regulation Of JUN Kinase Activity Negative Regulation Of Protein Localization To Nucleus Lipid Localization Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Lung Goblet Cell Differentiation Regulation Of Cholesterol Import Negative Regulation Of Intracellular Protein Transport Tissue Development Regulation Of Transcription Factor Import Into Nucleus Developmental Process Positive Regulation Of Nucleocytoplasmic Transport Lobar Bronchus Development Release Of Cytoplasmic Sequestered NF-kappaB Diacylglycerol Catabolic Process Lipid Homeostasis	Cholesterol Efflux Lipid Transport Lipid Localization Sterol Transport Cholesterol Transport High-density Lipoprotein Particle Remodeling Cholesterol Metabolic Process Plasma Lipoprotein Particle Remodeling Sterol Metabolic Process Plasma Lipoprotein Particle Clearance Cholesterol Import Regulation Of Phosphatidylcholine Catabolic Process Regulation Of Lipid Catabolic Process High-density Lipoprotein Particle Clearance Regulation Of Plasma Lipoprotein Particle Levels Steroid Metabolic Process Positive Regulation Of Cholesterol Esterification Regulation Of Lipid Metabolic Process Lipid Metabolic Process Phospholipid Transport Regulation Of Cholesterol Esterification Peripheral Nervous System Axon Regeneration Phospholipid Efflux Alcohol Metabolic Process Small Molecule Metabolic Process Protein-lipid Complex Assembly Endothelial Cell Proliferation Regulation Of Lipid Biosynthetic Process Reverse Cholesterol Transport Negative Regulation Of Lipase Activity Lipoprotein Metabolic Process Positive Regulation Of Steroid Metabolic Process Regulation Of Endocytosis Blood Vessel Endothelial Cell Migration Regulation Of Fatty Acid Biosynthetic Process Regulation Of Triglyceride Metabolic Process Wound Healing Triglyceride Homeostasis Acylglycerol Homeostasis Regulation Of Cholesterol Transport Axon Regeneration Response To Wounding Neuron Projection Regeneration Regulation Of Inflammatory Response Sperm Motility Transport Positive Regulation Of Lipid Biosynthetic Process Regulation Of Phagocytosis Response To Axon Injury Negative Regulation Of Phosphatidylcholine Catabolic Process
Tagcloud ?		5k3 alpl armitage beadchip bovinesnp50 bull capn1 cohran dehygrogenase ethanolamine etnk1 friesian goldenhelix hibadh hydroxyisobutyrate kelch klhl1 loc785875 mc4r pdzrn4 prkcb rs110596818 rs110827324 rs110876480 rs29011704 sire srd5a2 svs7 trim36	atp1 craniorachischisis d1hun13 d1hun14 d1mit110 d1mit111 d1mit112 d1mit114 d1mit145 d1mit146 d1mit147 d1mit148 d1mit149 d1mit15 d1mit205 d1mit270 d1mit36 d1mit62 eph1 fcer1 fcgr2 hlix1 intergene interlocus looptail spna1 spretus sslp swr
Tagcloud (Difference) ?		5k3 alpl armitage beadchip bovinesnp50 bull capn1 cohran dehygrogenase ethanolamine etnk1 friesian goldenhelix hibadh hydroxyisobutyrate kelch klhl1 loc785875 mc4r pdzrn4 prkcb rs110596818 rs110827324 rs110876480 rs29011704 sire srd5a2 svs7 trim36	atp1 craniorachischisis d1hun13 d1hun14 d1mit110 d1mit111 d1mit112 d1mit114 d1mit145 d1mit146 d1mit147 d1mit148 d1mit149 d1mit15 d1mit205 d1mit270 d1mit36 d1mit62 eph1 fcer1 fcgr2 hlix1 intergene interlocus looptail spna1 spretus sslp swr
Tagcloud (Intersection) ?