CYR61 and ITGAV

Number of citations of the paper that reports this interaction (PMID 11287419)
33

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		CYR61	ITGAV
Gene Name		cysteine-rich, angiogenic inducer, 61	integrin, alpha V
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Extracellular Matrix	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Lamellipodium Membrane Filopodium Membrane Microvillus Membrane Ruffle Membrane Integrin Alphav-beta3 Complex Integrin Alphav-beta5 Complex Integrin Alphav-beta8 Complex Alphav-beta3 Integrin-IGF-1-IGF1R Complex Phagocytic Vesicle Extracellular Vesicular Exosome
	Molecular Function	Integrin Binding Insulin-like Growth Factor Binding Heparin Binding Extracellular Matrix Binding	Virus Receptor Activity Opsonin Binding Fibronectin Binding Protease Binding Protein Kinase C Binding Voltage-gated Calcium Channel Activity Protein Binding Insulin-like Growth Factor I Binding Metal Ion Binding Transforming Growth Factor Beta Binding Extracellular Matrix Binding Extracellular Matrix Protein Binding
	Biological Process	Regulation Of Cell Growth Osteoblast Differentiation Positive Regulation Of Protein Phosphorylation Intussusceptive Angiogenesis Atrioventricular Valve Morphogenesis Apoptotic Process Involved In Heart Morphogenesis Ventricular Septum Development Chemotaxis Cell Adhesion Cell-cell Signaling Cell Proliferation Anatomical Structure Morphogenesis Positive Regulation Of Phospholipase Activity Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization Positive Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Osteoblast Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Wound Healing, Spreading Of Cells Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Atrial Septum Morphogenesis Negative Regulation Of Cell Death Chondroblast Differentiation Chorio-allantoic Fusion Labyrinthine Layer Blood Vessel Development Positive Regulation Of Cartilage Development Regulation Of ERK1 And ERK2 Cascade Reactive Oxygen Species Metabolic Process Positive Regulation Of Ceramide Biosynthetic Process	Angiogenesis Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Positive Regulation Of Cell Proliferation Response To Virus Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Cell Growth Cell Migration Extracellular Matrix Organization Positive Regulation Of Cell Migration Cell-substrate Adhesion Negative Regulation Of Lipid Transport Positive Regulation Of Osteoblast Proliferation Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Apolipoprotein A-I-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Apoptotic Cell Clearance Negative Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Positive Regulation Of Cell Adhesion Viral Entry Into Host Cell Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Lipoprotein Metabolic Process Regulation Of Phagocytosis Leukocyte Migration Negative Chemotaxis Entry Of Symbiont Into Host Cell By Promotion Of Host Phagocytosis ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Apoptotic Cell Clearance Negative Regulation Of Entry Of Bacterium Into Host Cell Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Signal transduction by L1 Axon guidance Elastic fibre formation L1CAM interactions Non-integrin membrane-ECM interactions VEGFA-VEGFR2 Pathway Cell surface interactions at the vascular wall PECAM1 interactions Molecules associated with elastic fibres Syndecan interactions Laminin interactions Signaling by VEGF ECM proteoglycans Integrin cell surface interactions Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Cross-presentation of particulate exogenous antigens (phagosomes) Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: ITGAV ITGB5	28 interactors: ADAM9 ANGPTL3 AUP1 AZGP1 CALR CD47 CYR61 EDIL3 F2R ICAM4 ITGB1 ITGB3 ITGB5 ITGB6 ITGB8 L1CAM MMP14 MMP2 NID1 NOV P2RY2 PAK4 PDGFRA PLP1 PTK2 SPP1 TGFB1 THY1
Entrez ID		3491	3685
HPRD ID		09089	01903
Ensembl ID		ENSG00000142871	ENSG00000138448
Uniprot IDs		O00622 Q6FI18	B7ZLX0 P06756
PDB IDs			1JV2 1L5G 1M1X 1U8C 3IJE 4G1E 4G1M
Enriched GO Terms of Interacting Partners?		Endodermal Cell Differentiation Endoderm Formation Endoderm Development Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Integrin-mediated Signaling Pathway Formation Of Primary Germ Layer Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Cell-matrix Adhesion Gastrulation Negative Regulation Of Entry Of Bacterium Into Host Cell Entry Of Symbiont Into Host Cell By Promotion Of Host Phagocytosis Cell-substrate Adhesion Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Regulation Of Entry Of Bacterium Into Host Cell Negative Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Receptor Biosynthetic Process Apolipoprotein A-I-mediated Signaling Pathway Single Organismal Cell-cell Adhesion Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Negative Regulation Of Lipoprotein Metabolic Process Embryonic Morphogenesis Positive Regulation Of Osteoblast Proliferation Regulation Of Apoptotic Cell Clearance Regulation Of Lipoprotein Metabolic Process Stress Fiber Assembly Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Receptor Biosynthetic Process ERK1 And ERK2 Cascade Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Lipid Storage Negative Chemotaxis Heterotypic Cell-cell Adhesion Negative Regulation Of Lipid Transport Regulation Of Osteoblast Proliferation Anatomical Structure Formation Involved In Morphogenesis Embryo Development Cell Adhesion Apoptotic Cell Clearance Epithelial Cell-cell Adhesion Viral Entry Into Host Cell Entry Into Host Cell Substrate Adhesion-dependent Cell Spreading Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Phagocytosis Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Lipid Storage	Extracellular Matrix Organization Extracellular Structure Organization Cell Adhesion Integrin-mediated Signaling Pathway Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Cell Adhesion Positive Regulation Of Cell Motility Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Cell-matrix Adhesion Regulation Of Locomotion Regulation Of Cellular Component Movement Cell-substrate Adhesion Positive Regulation Of Cell Adhesion Locomotion Regulation Of Cell-substrate Adhesion Cardiovascular System Development Blood Vessel Development Response To External Stimulus Vasculature Development Single Organismal Cell-cell Adhesion Multicellular Organismal Development Cell Surface Receptor Signaling Pathway Developmental Process Blood Vessel Morphogenesis Cell Migration Tissue Development Cell Motility Angiogenesis Movement Of Cell Or Subcellular Component Positive Regulation Of Cell-substrate Adhesion Anatomical Structure Development Signaling Cell Communication Response To Stimulus Positive Regulation Of Cell Proliferation Signal Transduction Chemotaxis Wound Healing Organ Development Blood Coagulation Hemostasis System Development Cell-cell Adhesion Mediated By Integrin Single Organism Reproductive Process Response To Wounding Positive Regulation Of Kinase Activity Anatomical Structure Morphogenesis
Tagcloud ?		axis belongs canonical catenin ccn ccn6 closely collagen collagens ctgf cysteine cytoplasm dysregulated fibronectin gastric indicates inducible invasion matricellular nov positively silencing suppressed tcf transferring validation wisp3 wnt wnt1	bcl colorectal corresponding crc dissemination event extracellular ihc immunohistochemistry invasion ki matrix metastasis neoplastic overexpression perineural polymerase progression quantitative real regard resection sparc spread thbs1 underwent validation vcam vegf
Tagcloud (Difference) ?		axis belongs canonical catenin ccn ccn6 closely collagen collagens ctgf cysteine cytoplasm dysregulated fibronectin gastric indicates inducible matricellular nov positively silencing suppressed tcf transferring wisp3 wnt wnt1	bcl colorectal corresponding crc dissemination event extracellular ihc immunohistochemistry ki matrix metastasis neoplastic overexpression perineural polymerase progression quantitative real regard resection sparc spread thbs1 underwent vcam vegf
Tagcloud (Intersection) ?		invasion validation