CYR61 and ITGB5

Number of citations of the paper that reports this interaction (PMID 11287419)
33

Data Source:
HPRD (in vitro)

		CYR61	ITGB5
Gene Name		cysteine-rich, angiogenic inducer, 61	integrin, beta 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Extracellular Matrix	Plasma Membrane Focal Adhesion Cell Surface Cell Leading Edge Integrin Alphav-beta5 Complex Receptor Complex Phagocytic Vesicle Extracellular Vesicular Exosome
	Molecular Function	Integrin Binding Insulin-like Growth Factor Binding Heparin Binding Extracellular Matrix Binding	Receptor Activity Integrin Binding Protein Binding
	Biological Process	Regulation Of Cell Growth Osteoblast Differentiation Positive Regulation Of Protein Phosphorylation Intussusceptive Angiogenesis Atrioventricular Valve Morphogenesis Apoptotic Process Involved In Heart Morphogenesis Ventricular Septum Development Chemotaxis Cell Adhesion Cell-cell Signaling Cell Proliferation Anatomical Structure Morphogenesis Positive Regulation Of Phospholipase Activity Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization Positive Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Osteoblast Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Wound Healing, Spreading Of Cells Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Atrial Septum Morphogenesis Negative Regulation Of Cell Death Chondroblast Differentiation Chorio-allantoic Fusion Labyrinthine Layer Blood Vessel Development Positive Regulation Of Cartilage Development Regulation Of ERK1 And ERK2 Cascade Reactive Oxygen Species Metabolic Process Positive Regulation Of Ceramide Biosynthetic Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Muscle Contraction Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Extracellular Matrix Organization Endodermal Cell Differentiation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Stress Fiber Assembly Epithelial Cell-cell Adhesion
Pathways			Elastic fibre formation Smooth Muscle Contraction Non-integrin membrane-ECM interactions Molecules associated with elastic fibres Syndecan interactions ECM proteoglycans Integrin cell surface interactions Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Cross-presentation of particulate exogenous antigens (phagosomes) Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: ITGAV ITGB5	34 interactors: ANXA5 CYR61 DAB1 DAB2 DOK1 EHMT2 EPS8 EWSR1 FHL2 FLNA GNB2L1 ITGA5 ITGAV ITGB3BP KRT40 KRTAP10-8 KRTAP10-9 LTBP1 LTBP3 MTUS2 MYO10 NOTCH2NL NUMB P2RY2 PAK4 PALLD PIAS2 PPARD PTK2 SNTA1 SRSF9 TLN1 TNS2 ZBTB17
Entrez ID		3491	3693
HPRD ID		09089	00949
Ensembl ID		ENSG00000142871	ENSG00000082781
Uniprot IDs		O00622 Q6FI18	L7RT22 P18084
PDB IDs
Enriched GO Terms of Interacting Partners?		Endodermal Cell Differentiation Endoderm Formation Endoderm Development Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Integrin-mediated Signaling Pathway Formation Of Primary Germ Layer Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Cell-matrix Adhesion Gastrulation Negative Regulation Of Entry Of Bacterium Into Host Cell Entry Of Symbiont Into Host Cell By Promotion Of Host Phagocytosis Cell-substrate Adhesion Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Regulation Of Entry Of Bacterium Into Host Cell Negative Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Receptor Biosynthetic Process Apolipoprotein A-I-mediated Signaling Pathway Single Organismal Cell-cell Adhesion Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Negative Regulation Of Lipoprotein Metabolic Process Embryonic Morphogenesis Positive Regulation Of Osteoblast Proliferation Regulation Of Apoptotic Cell Clearance Regulation Of Lipoprotein Metabolic Process Stress Fiber Assembly Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Receptor Biosynthetic Process ERK1 And ERK2 Cascade Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Lipid Storage Negative Chemotaxis Heterotypic Cell-cell Adhesion Negative Regulation Of Lipid Transport Regulation Of Osteoblast Proliferation Anatomical Structure Formation Involved In Morphogenesis Embryo Development Cell Adhesion Apoptotic Cell Clearance Epithelial Cell-cell Adhesion Viral Entry Into Host Cell Entry Into Host Cell Substrate Adhesion-dependent Cell Spreading Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Phagocytosis Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Lipid Storage	Signaling Cell Communication Signal Transduction Regulation Of Cellular Process Cellular Response To Stimulus Regulation Of Cellular Component Movement Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Locomotion Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Anatomical Structure Morphogenesis Response To Stimulus Regulation Of Cell Migration Wound Healing Cell Development Regulation Of Cell Motility Movement Of Cell Or Subcellular Component Regulation Of Locomotion Response To Wounding Cell Morphogenesis Involved In Differentiation Negative Regulation Of Cell Death Positive Regulation Of Protein Phosphorylation Cell Differentiation Extracellular Matrix Organization Extracellular Structure Organization Cell Migration Regulation Of Apoptotic Process Cell Surface Receptor Signaling Pathway Chemotaxis Positive Regulation Of Phosphorylation Axon Guidance Multicellular Organismal Development Regulation Of Cell Adhesion Cell Motility Positive Regulation Of Protein Modification Process Regulation Of Cell Death Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Blood Coagulation Negative Regulation Of Programmed Cell Death Hemostasis Developmental Process Anatomical Structure Development Apoptotic Process Positive Regulation Of Protein Kinase Activity Programmed Cell Death Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Cell Morphogenesis
Tagcloud ?		axis belongs canonical catenin ccn ccn6 closely collagen collagens ctgf cysteine cytoplasm dysregulated fibronectin gastric indicates inducible invasion matricellular nov positively silencing suppressed tcf transferring validation wisp3 wnt wnt1	concurrently ctsk dc dendritic elucidated enhancer imply isoform itga2 itga5 itgav itgb1 itgb3 microphthalmia mitf multinucleated nfatc1 osteoclast osteoclastogenesis osteoclasts potentiated rankl raw264 resembled stamp tartrate tgf transforming transmembrane
Tagcloud (Difference) ?		axis belongs canonical catenin ccn ccn6 closely collagen collagens ctgf cysteine cytoplasm dysregulated fibronectin gastric indicates inducible invasion matricellular nov positively silencing suppressed tcf transferring validation wisp3 wnt wnt1	concurrently ctsk dc dendritic elucidated enhancer imply isoform itga2 itga5 itgav itgb1 itgb3 microphthalmia mitf multinucleated nfatc1 osteoclast osteoclastogenesis osteoclasts potentiated rankl raw264 resembled stamp tartrate tgf transforming transmembrane
Tagcloud (Intersection) ?