CCN1 and SMPD2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CCN1	SMPD2
Description		cellular communication network factor 1	sphingomyelin phosphodiesterase 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix	Endoplasmic Reticulum Plasma Membrane Caveola Membrane Cell Periphery
	Molecular Function	Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Heparin Binding Growth Factor Binding Extracellular Matrix Binding	Catalytic Activity Sphingomyelin Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Osteoblast Differentiation Intussusceptive Angiogenesis Atrioventricular Valve Morphogenesis Apoptotic Process Involved In Heart Morphogenesis Ventricular Septum Development Apoptotic Process Chemotaxis Cell Adhesion Signal Transduction Integrin-mediated Signaling Pathway Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Osteoblast Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Developmental Process Atrial Septum Morphogenesis Chondroblast Differentiation Chorio-allantoic Fusion Labyrinthine Layer Blood Vessel Development Positive Regulation Of Cartilage Development Regulation Of ERK1 And ERK2 Cascade Reactive Oxygen Species Metabolic Process Cell-cell Adhesion Regulation Of Multicellular Organismal Development Positive Regulation Of Ceramide Biosynthetic Process	Lipid Metabolic Process Sphingolipid Metabolic Process Ceramide Metabolic Process Sphingomyelin Metabolic Process Sphingomyelin Catabolic Process Response To Mechanical Stimulus Sphingolipid Catabolic Process Intracellular Signal Transduction Ceramide Biosynthetic Process
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Ceramide signalling TNFR1-mediated ceramide production Glycosphingolipid catabolism
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823)	Height ( 18391951)
Interacting Genes		8 interacting genes: ANXA1 CDC42 DYRK1A ITGAV ITGB5 NEIL3 SMPD2 UBQLN2	15 interacting genes: ARFIP1 CCN1 COQ8A GAD2 NDRG4 PBX3 PGRMC2 PIK3CG PITPNC1 SLC10A1 SLC7A8 STAR TMEM14B TMEM167B TMEM31
Entrez ID		3491	6610
HPRD ID		09089	04608
Ensembl ID		ENSG00000142871	ENSG00000135587
Uniprot IDs		O00622 Q6FI18	O60906
PDB IDs		4D0Z 4D11	8J2F
Enriched GO Terms of Interacting Partners?		Integrin Alphav-beta5 Complex Regulation Of Vesicle-mediated Transport Phagocytic Vesicle Regulation Of Endocytosis Integrin-mediated Signaling Pathway Mononuclear Cell Migration Wound Healing, Spreading Of Epidermal Cells Focal Adhesion Cell Migration Endocytosis Apoptotic Cell Clearance Cell Motility Integrin Complex Cell Adhesion Mediated By Integrin Wound Healing, Spreading Of Cells Endodermal Cell Differentiation Import Into Cell Leukocyte Migration Regulation Of Cellular Component Organization Regulation Of Cell Adhesion Chemotaxis Regulation Of Interleukin-2 Production Histone H3T45 Kinase Activity Entry Into Host Cell By A Symbiont-containing Vacuole Formation Of Primary Germ Layer Opsonin Binding MCM Complex Binding Regulation Of Transport Locomotion Actin Cytoskeleton Organization Signaling Receptor Binding Actin Filament-based Process Phagocytosis Actin Filament GBD Domain Binding Storage Vacuole Integrin Alphav-beta3 Complex Negative Regulation Of Entry Of Bacterium Into Host Cell Integrin Alphav-beta1 Complex Integrin Alphav-beta6 Complex Virus Receptor Activity Integrin Alphav-beta8 Complex Negative Regulation Of G Protein-coupled Receptor Internalization Cell Periphery Negative Regulation Of Transport Regulation Of Phagocytosis Cell-matrix Adhesion Endothelin Receptor Signaling Pathway Involved In Heart Process Alphav-beta3 Integrin-PKCalpha Complex Alphav-beta3 Integrin-HMGB1 Complex
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?