IGFALS and IGFBP5

Number of citations of the paper that reports this interaction (PMID 9497324)
15

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		IGFALS	IGFBP5
Gene Name		insulin-like growth factor binding protein, acid labile subunit	insulin-like growth factor binding protein 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Insulin-like Growth Factor Binding Protein Complex
	Molecular Function	Insulin-like Growth Factor Binding	Fibronectin Binding Protein Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding
	Biological Process	Cell Adhesion Signal Transduction Cellular Protein Metabolic Process	Regulation Of Cell Growth Osteoblast Differentiation Glucose Metabolic Process Signal Transduction Regulation Of Glucose Metabolic Process Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Translation Negative Regulation Of Cell Migration Hair Follicle Morphogenesis Intracellular Signal Transduction Glucose Homeostasis Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Type B Pancreatic Cell Proliferation Negative Regulation Of Osteoblast Differentiation Skeletal Muscle Tissue Growth Negative Regulation Of Smooth Muscle Cell Proliferation Striated Muscle Cell Differentiation Positive Regulation Of Protein Kinase B Signaling Mammary Gland Involution Cellular Response To CAMP Cellular Response To Organic Cyclic Compound
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases
GWAS		Insulin-like growth factors ( 21216879)	Thyroid hormone levels ( 23408906) Visceral fat ( 22589738)
Protein-Protein Interactions		4 interactors: IGF1 IGFBP3 IGFBP5 PDCD6	17 interactors: ADAM12 BAG6 F2 FHL2 FN1 IGF1 IGF2 IGFALS KPNB1 PAPPA2 PNO1 RASSF1 SERPINE1 SPP1 TF THBS1 VTN
Entrez ID		3483	3488
HPRD ID		03290	00901
Ensembl ID		ENSG00000099769	ENSG00000115461
Uniprot IDs		P35858 Q8TAY0	P24593
PDB IDs			1BOE 1H59
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Smooth Muscle Cell Migration Regulation Of Smooth Muscle Cell Proliferation Regulation Of Glucose Metabolic Process Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Protein Kinase B Signaling Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Carbohydrate Metabolic Process Type B Pancreatic Cell Proliferation Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Ossification Regulation Of Cell Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase B Signaling Regulation Of Growth Regulation Of Protein Metabolic Process Negative Regulation Of Cell Proliferation Cell Proliferation Response To Heat Tissue Remodeling Positive Regulation Of Intracellular Signal Transduction Regulation Of Osteoblast Differentiation Regulation Of Signal Transduction Osteoblast Differentiation Positive Regulation Of Epithelial Cell Proliferation Apoptotic Process Gland Morphogenesis Regulation Of Signaling Programmed Cell Death Mammary Gland Development Cell Death Death Response To Temperature Stimulus Negative Regulation Of Cell Migration Regulation Of Ossification Prostate Gland Stromal Morphogenesis Glycolate Metabolic Process Skeletal Muscle Tissue Growth Negative Regulation Of Cell Motility Negative Regulation Of Cellular Component Movement Striated Muscle Cell Differentiation Positive Regulation Of Signal Transduction Negative Regulation Of Oocyte Development	Platelet Degranulation Platelet Activation Blood Coagulation Hemostasis Positive Regulation Of Wound Healing Negative Regulation Of Fibrinolysis Regulation Of Body Fluid Levels Exocytosis Wound Healing Regulation Of Fibrinolysis Cell Activation Response To Wounding Regulation Of Blood Coagulation Secretion By Cell Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Response To Stress Positive Regulation Of Blood Coagulation Response To Stimulus Regulation Of Wound Healing Regulation Of Cell Adhesion Secretion Positive Regulation Of Coagulation Negative Regulation Of Proteolysis Regulation Of Protein Metabolic Process Regulation Of Proteolysis Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Protein Processing Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cell Adhesion Positive Regulation Of Cellular Protein Metabolic Process Anatomical Structure Development Regulation Of Protein Processing Negative Regulation Of Blood Coagulation Anatomical Structure Morphogenesis Positive Regulation Of Protein Metabolic Process Regulation Of Cell-substrate Adhesion Negative Regulation Of Coagulation Negative Regulation Of Plasminogen Activation Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Wound Healing Cell Differentiation Striated Muscle Cell Differentiation Developmental Process Exocrine Pancreas Development Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Kinase B Signaling Vesicle-mediated Transport Ossification
Tagcloud ?		112g 11p15 1291delt 45m 6psi ccdc8 cul7 encompasses genetics ghi ghr height homozygous hypomethylation igf1 imprinting insensitive insensitivity ivs5ds justifying mupd7 obsl1 pseudoexon russell sds srs stat5b stature suspected	4h antisense autocrine benzopyran c2 igfr igfs indirectly ly294002 messenger modulated morpholinyl myoblast myoblasts p70 p70s6k persisted phenyl phosphatidylinositol pi3 prevents proliferating quiescent rapamycin s6 stably wortmaninn
Tagcloud (Difference) ?		112g 11p15 1291delt 45m 6psi ccdc8 cul7 encompasses genetics ghi ghr height homozygous hypomethylation igf1 imprinting insensitive insensitivity ivs5ds justifying mupd7 obsl1 pseudoexon russell sds srs stat5b stature suspected	4h antisense autocrine benzopyran c2 igfr igfs indirectly ly294002 messenger modulated morpholinyl myoblast myoblasts p70 p70s6k persisted phenyl phosphatidylinositol pi3 prevents proliferating quiescent rapamycin s6 stably wortmaninn
Tagcloud (Intersection) ?