KL

Gene Name		klotho
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Beta-glucuronidase Activity Signal Transducer Activity Fibroblast Growth Factor Receptor Binding Hormone Activity Vitamin D Binding Beta-glucosidase Activity Fibroblast Growth Factor Binding
	Biological Process	Acute Inflammatory Response Carbohydrate Metabolic Process Energy Reserve Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway Aging Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Bone Mineralization Fc-epsilon Receptor Signaling Pathway Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Calcium Ion Homeostasis Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions		1 interactors: IGF1R
Entrez ID		9365
HPRD ID		05316
Ensembl ID		ENSG00000133116
Uniprot IDs		Q9UEF7
PDB IDs
Enriched GO Terms of Interacting Partners?		Inactivation Of MAPKK Activity Exocrine Pancreas Development Positive Regulation Of Steroid Hormone Biosynthetic Process Positive Regulation Of Hormone Biosynthetic Process Male Sex Determination Response To Vitamin E Insulin-like Growth Factor Receptor Signaling Pathway Phosphatidylinositol 3-kinase Signaling Sex Determination Regulation Of Hormone Biosynthetic Process Positive Regulation Of Steroid Metabolic Process Regulation Of Hormone Metabolic Process Negative Regulation Of Muscle Cell Apoptotic Process Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Protein Kinase B Signaling Positive Regulation Of Cytokinesis Prostate Gland Epithelium Morphogenesis Positive Regulation Of Mitotic Nuclear Division Prostate Gland Morphogenesis Regulation Of Muscle Cell Apoptotic Process Regulation Of Cytokinesis Exocrine System Development Positive Regulation Of Lipid Biosynthetic Process Positive Regulation Of DNA Replication Prostate Gland Development Regulation Of Steroid Biosynthetic Process Positive Regulation Of Protein Kinase B Signaling Pancreas Development Regulation Of Steroid Metabolic Process Protein Tetramerization Response To Vitamin Establishment Of Cell Polarity Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Mitotic Nuclear Division Regulation Of Protein Kinase B Signaling Positive Regulation Of Cell Division Regulation Of DNA Replication Protein Heterooligomerization Regulation Of Lipid Biosynthetic Process Phosphatidylinositol-mediated Signaling Positive Regulation Of DNA Metabolic Process Digestive System Development Insulin Receptor Signaling Pathway Negative Regulation Of MAPK Cascade Gland Morphogenesis Regulation Of JNK Cascade Mammary Gland Development Establishment Or Maintenance Of Cell Polarity Regulation Of Stress-activated MAPK Cascade
Tagcloud ?		agonistic analogues antagonistic antagonists bu continuing couplings dehydrophenylalanine deltaphe dipeptide dphe fluorine fmoc gives gly guinea ileum iodine kh mtr phe pig position pybop radioligand replacement resin substitutions wang