KL

Description		klotho
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Beta-glucuronidase Activity Fibroblast Growth Factor Receptor Binding Hormone Activity Vitamin D Binding Beta-glucosidase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Fibroblast Growth Factor Binding
	Biological Process	Negative Regulation Of Systemic Arterial Blood Pressure Carbohydrate Metabolic Process Energy Reserve Metabolic Process Determination Of Adult Lifespan Fibroblast Growth Factor Receptor Signaling Pathway Response To Activity Positive Regulation Of Bone Mineralization Response To Vitamin D Norepinephrine Biosynthetic Process Calcium Ion Homeostasis Response To Fibroblast Growth Factor Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Response To Angiotensin
Pathways
Drugs
Diseases
GWAS		Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Birth weight ( 31043758) Fasting blood glucose ( 25631608) Fasting glucose ( 34059833) Glycated hemoglobin levels ( 34059833) LDL cholesterol levels in HIV infection ( 33109212) Mild age-related type 2 diabetes ( 34737425) Multiple sclerosis ( 24076602) Type 2 diabetes ( 28869590 30054458 30297969 30718926 32499647)
Interacting Genes		1 interacting genes: IGF1R
Entrez ID		9365
HPRD ID		05316
Ensembl ID		ENSG00000133116
Uniprot IDs		Q9UEF7
PDB IDs		5W21 7YSH 7YSU 7YSW 8TOH 8UF8
Enriched GO Terms of Interacting Partners?		Insulin-like Growth Factor Receptor Activity Protein Kinase Complex Insulin Receptor Complex Alphav-beta3 Integrin-IGF-1-IGF1R Complex Insulin Receptor Activity Insulin Binding Peptidyl-tyrosine Autophosphorylation Insulin-like Growth Factor Binding Insulin-like Growth Factor I Binding Dendritic Spine Maintenance Insulin Receptor Substrate Binding Protein Transporter Activity Phosphatidylinositol 3-kinase Binding Transcytosis Insulin Receptor Binding Amyloid-beta Clearance Dendritic Spine Organization Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein-containing Complex Disassembly Transmembrane Receptor Protein Tyrosine Kinase Activity Neuron Projection Organization Cellular Response To Amyloid-beta Postsynapse Organization Peptidyl-tyrosine Phosphorylation Cellular Component Maintenance Cellular Response To Glucose Stimulus Response To Amyloid-beta Cellular Response To Carbohydrate Stimulus Insulin Receptor Signaling Pathway Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Intracellular Glucose Homeostasis Positive Regulation Of Cold-induced Thermogenesis Protein Autophosphorylation Response To Glucose Regulation Of Protein-containing Complex Disassembly Protein Tyrosine Kinase Activity Response To Monosaccharide Regulation Of Cold-induced Thermogenesis Regulation Of JNK Cascade Response To Carbohydrate Negative Regulation Of MAPK Cascade Structural Molecule Activity Carbohydrate Homeostasis Receptor Complex Glucose Homeostasis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
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