DGAT2L6 and HSD17B11

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DGAT2L6	HSD17B11
Description		diacylglycerol O-acyltransferase 2 like 6	hydroxysteroid 17-beta dehydrogenase 11
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Cytoplasm Endoplasmic Reticulum Lipid Droplet Cytosol
	Molecular Function	Diacylglycerol O-acyltransferase Activity Protein Binding O-acyltransferase Activity Transferase Activity Acyltransferase Activity	Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Protein Binding Steroid Dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor
	Biological Process	Lipid Metabolic Process Monoacylglycerol Biosynthetic Process Acylglycerol Acyl-chain Remodeling	Lipid Metabolic Process Steroid Biosynthetic Process Estrogen Biosynthetic Process Androgen Catabolic Process
Pathways		Acyl chain remodeling of DAG and TAG	Estrogen biosynthesis
Drugs			Aetiocholanolone
Diseases
GWAS			Appendicular lean mass ( 28724990) Bulimia nervosa ( 23568457) Lean body mass ( 28724990)
Interacting Genes		45 interacting genes: ABHD4 ABHD5 ACSF2 AQP6 ARFIP2 BNIP2 CIAO2A DIABLO ECPAS FARS2 FBXL19 FCER1G GAD2 GPR152 HSD17B11 MCEMP1 MPP1 MTERF4 MYG1 NAPB NDRG4 PBX3 PGRMC2 PITPNC1 REEP4 RNF144A RNF5 RUSF1 SCAND1 SCN3B SLC10A1 SLC10A6 SMG9 SNX4 STAR THAP4 TMED8 TMEM143 TMEM14B TMEM255B TMEM31 TMX2 TTPA TUFM WIPI2	54 interacting genes: ADIPOQ AGPAT3 AGPAT4 ANKRD46 BNIP1 CMTM3 CSGALNACT2 CYBC1 DGAT2L6 DHRSX EHHADH ERG28 FAM241B GIMAP1 GOLT1A HTATIP2 LRCH4 MS4A1 NEU1 ORMDL1 OTULINL PLP2 PRAF2 PTPN9 RASGRP3 RMDN2 RTP2 SEC22A SERPINE1 SFRP4 SFT2D2 SFXN3 SLC25A46 SLC30A8 SLC67A1 STRIT1 STX7 SYS1 TMEM120B TMEM128 TMEM14B TMEM167B TMEM203 TMEM242 TMEM42 TMEM65 TMX2 TPRG1 TTPA TVP23B UBC UNC50 VEZT YIPF6
Entrez ID		347516	51170
HPRD ID		13141	10881
Ensembl ID		ENSG00000184210	ENSG00000198189
Uniprot IDs		Q6ZPD8	Q8NBQ5
PDB IDs			1YB1
Enriched GO Terms of Interacting Partners?			Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Golgi Membrane Protein Binding Endomembrane System SNAP Receptor Activity
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