ZSWIM8 and PRMT2

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		ZSWIM8	PRMT2
Description		zinc finger SWIM-type containing 8	protein arginine methyltransferase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cul2-RING Ubiquitin Ligase Complex Cul3-RING Ubiquitin Ligase Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	Zinc Ion Binding Metal Ion Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Transcription Coactivator Activity Protein Binding Methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Nuclear Estrogen Receptor Binding Nuclear Progesterone Receptor Binding Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Protein Homodimerization Activity Nuclear Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Protein-containing Complex Binding Nuclear Thyroid Hormone Receptor Binding Nuclear Androgen Receptor Binding Histone H3R8 Methyltransferase Activity Histone H3 Methyltransferase Activity
	Biological Process	Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Type I Interferon-mediated Signaling Pathway Target-directed MiRNA Degradation Positive Regulation Of MiRNA Catabolic Process	Chromatin Remodeling Regulation Of DNA-templated Transcription Protein Methylation Signal Transduction Negative Regulation Of NF-kappaB Transcription Factor Activity Methylation Positive Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Developmental Cell Growth Negative Regulation Of Inflammatory Response Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Regulation of expression of SLITs and ROBOs
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease ( 28067908)	Diverticular disease ( 30177863)
Interacting Genes		5 interacting genes: ATN1 ATXN1 ATXN1L CTDSP1 PRMT2	37 interacting genes: BAG6 CBLB CHEK2 CPSF7 DAZAP1 DMRTB1 ESR1 ESR2 FIP1L1 HNRNPA1 HNRNPUL1 IQSEC2 KDM6B MYO6 NCOA1 NCOA6 PGR PRMT8 PRRC2A PSMB3 R3HDM1 RB1 RBM12 RBM22 RIPK2 RXRA SHANK1 SHANK3 SHTN1 SPAG8 THRB WASL WBP11 YLPM1 ZFP36 ZNF341 ZSWIM8
Entrez ID		23053	3275
HPRD ID		17199	09060
Ensembl ID		ENSG00000214655	ENSG00000160310
Uniprot IDs		A7E2V4 S4R410	A0A0S2Z3N3 P55345
PDB IDs			1X2P
Enriched GO Terms of Interacting Partners?		POZ Domain Binding Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Social Behavior Lung Alveolus Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Histone H3R8 Methyltransferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Memory Nuclear Matrix Nuclear Progesterone Receptor Binding Nucleoplasm Regulation Of G1/S Transition Of Mitotic Cell Cycle Learning Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Nucleolus Protein-arginine Omega-N Asymmetric Methyltransferase Activity Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Brain Development RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Negative Regulation Of Macromolecule Metabolic Process Protein-arginine N-methyltransferase Activity Negative Regulation Of Cell Cycle Process Poly(G) Binding Learning Or Memory Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Hematopoietic Stem Cell Proliferation Transcription Coactivator Activity Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Peroxisome Proliferator Activated Receptor Binding Regulation Of Macromolecule Metabolic Process Cognition Nuclear Inclusion Body Regulation Of Mitotic Cell Cycle Phase Transition	Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme Binding Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nuclear Receptor-mediated Signaling Pathway Nuclear Receptor Activity Positive Regulation Of Biosynthetic Process Nuclear Steroid Receptor Activity Nucleus Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process MRNA Metabolic Process Intracellular Receptor Signaling Pathway RNA Metabolic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Hormone-mediated Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Estrogen Response Element Binding Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Sequence-specific DNA Binding Dendritic Spine Morphogenesis Nucleic Acid Metabolic Process Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Estrogen Receptor Signaling Pathway Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nuclear Estrogen Receptor Activity Synaptic Receptor Adaptor Activity Regulation Of Transcription By RNA Polymerase II Steroid Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Dendritic Spine Organization RNA Binding Nuclear Estrogen Receptor Binding Neuron Projection Organization Postsynapse Organization Regulation Of Female Receptivity Female Mating Behavior MRNA Transcription By RNA Polymerase II
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