ZSWIM8

Description		zinc finger SWIM-type containing 8
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cul2-RING Ubiquitin Ligase Complex Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Zinc Ion Binding Metal Ion Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Type I Interferon-mediated Signaling Pathway Target-directed MiRNA Degradation Positive Regulation Of MiRNA Catabolic Process
Pathways		Regulation of expression of SLITs and ROBOs
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease ( 28067908)
Interacting Genes		5 interacting genes: ATN1 ATXN1 ATXN1L CTDSP1 PRMT2
Entrez ID		23053
HPRD ID		17199
Ensembl ID		ENSG00000214655
Uniprot IDs		A7E2V4 S4R410
PDB IDs
Enriched GO Terms of Interacting Partners?		POZ Domain Binding Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Social Behavior Lung Alveolus Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Histone H3R8 Methyltransferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Memory Nuclear Matrix Nuclear Progesterone Receptor Binding Nucleoplasm Regulation Of G1/S Transition Of Mitotic Cell Cycle Learning Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Nucleolus Protein-arginine Omega-N Asymmetric Methyltransferase Activity Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Brain Development RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Negative Regulation Of Macromolecule Metabolic Process Protein-arginine N-methyltransferase Activity Negative Regulation Of Cell Cycle Process Poly(G) Binding Learning Or Memory Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Hematopoietic Stem Cell Proliferation Transcription Coactivator Activity Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Peroxisome Proliferator Activated Receptor Binding Regulation Of Macromolecule Metabolic Process Cognition Nuclear Inclusion Body Regulation Of Mitotic Cell Cycle Phase Transition
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