IDI1 and TXNIP

Number of citations of the paper that reports this interaction (PubMedID 31669268)
0

Data Source:
BioGRID (two hybrid)

		IDI1	TXNIP
Description		isopentenyl-diphosphate delta isomerase 1	thioredoxin interacting protein
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GO Annotations	Cellular Component	Cytoplasm Peroxisome Cytosol	Nucleus Cytoplasm Cytosol
	Molecular Function	Magnesium Ion Binding Isopentenyl-diphosphate Delta-isomerase Activity Protein Binding Isomerase Activity Intramolecular Oxidoreductase Activity Manganese Ion Binding Metal Ion Binding	Enzyme Inhibitor Activity Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Isoprenoid Biosynthetic Process Isopentenyl Diphosphate Biosynthetic Process Sterol Biosynthetic Process Response To Stilbenoid Dimethylallyl Diphosphate Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Inflammatory Response Response To Oxidative Stress Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Glucose Protein Transport Keratinocyte Differentiation Response To Estradiol Response To Progesterone Regulation Of Cell Population Proliferation Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Response To Calcium Ion Negative Regulation Of Cell Division Cellular Response To Tumor Cell Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus
Pathways		Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)	The NLRP3 inflammasome The NLRP3 inflammasome Regulation of FOXO transcriptional activity by acetylation Purinergic signaling in leishmaniasis infection Purinergic signaling in leishmaniasis infection Cytoprotection by HMOX1
Drugs		Dimethylallyl Diphosphate
Diseases
GWAS
Interacting Genes		5 interacting genes: BARD1 BCL2L13 TXNIP WT1 ZNF655	30 interacting genes: CBX8 DDIT4 ECD EEF1A1 FHL1 GAPDH HDAC1 HDAC3 HSPB2 IDI1 INTS9 KPNA2 LUC7L3 MAPK1 NLGN3 PRKAA1 PTPN11 RUVBL2 SCEL SIVA1 SLC2A1 SMURF2 TRAF6 TXN TXNRD1 UBR5 UXT WWP1 ZBTB16 ZBTB32
Entrez ID		3422	10628
HPRD ID		07235	05964
Ensembl ID		ENSG00000067064	ENSG00000265972
Uniprot IDs		A0A8Q3WKR8 Q13907	Q9H3M7
PDB IDs		2DHO 2I6K 2ICJ 2ICK	4GEI 4GEJ 4GFX 4LL1 4LL4 4ROF 4ROJ 5CQ2 5DF6 5DWS 5DZD
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Programmed Cell Death BRCA1-B Complex Regulation Of Programmed Cell Death Histone H2AK127 Ubiquitin Ligase Activity Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Histone H2AK129 Ubiquitin Ligase Activity Negative Regulation Of MRNA 3'-end Processing BRCA1-BARD1 Complex Hemi-methylated DNA-binding Negative Regulation Of Female Gonad Development Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Negative Regulation Of Glomerular Mesangial Cell Proliferation Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Metanephric S-shaped Body Morphogenesis Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Cellular Response To Tumor Cell BRCA1-A Complex Nuclear Ubiquitin Ligase Complex Negative Regulation Of Protein Export From Nucleus BRCA1-C Complex Negative Regulation Of Mitotic Cell Cycle Phase Transition Ubiquitin-modified Histone Reader Activity Negative Regulation Of Mitotic Cell Cycle Diaphragm Development Negative Regulation Of Cell Proliferation Involved In Kidney Development Regulation Of Female Gonad Development Thorax And Anterior Abdomen Determination Positive Regulation Of Male Gonad Development S-shaped Body Morphogenesis Cardiac Muscle Cell Fate Commitment Double-stranded Methylated DNA Binding Metanephric Mesenchyme Development Positive Regulation Of 3'-UTR-mediated MRNA Stabilization Negative Regulation Of Cell Cycle Phase Transition Regulation Of MRNA 3'-end Processing Zinc Ion Binding Regulation Of RNA Metabolic Process Negative Regulation Of Cell Cycle Process Nucleolus Nephron Tubule Morphogenesis Podocyte Differentiation Glomerular Basement Membrane Development Regulation Of Glomerular Mesangial Cell Proliferation Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process DNA Strand Resection Involved In Replication Fork Processing Metanephric Epithelium Development	Nucleus Cytosol Cytoplasm Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Protein Lysine Delactylase Activity Regulation Of Signal Transduction Positive Regulation Of Type I Interferon Production Negative Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Nucleoplasm Protein Decrotonylase Activity Histone Decrotonylase Activity Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Protein Export From Nucleus Regulation Of Protein Stability Regulation Of Gene Expression Positive Regulation Of Signal Transduction Protein Modification Process Regulation Of Cell Communication Regulation Of Macromolecule Biosynthetic Process Regulation Of Signaling Regulation Of RNA Metabolic Process Regulation Of Nucleocytoplasmic Transport Thioredoxin-disulfide Reductase (NADPH) Activity Regulation Of Canonical Wnt Signaling Pathway Regulation Of Primary Metabolic Process Regulation Of Type I Interferon Production Histone Deacetylase Binding Negative Regulation Of Protein Export From Nucleus Transcription Corepressor Binding Regulation Of Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Transport Response To Epidermal Growth Factor Regulation Of Intracellular Protein Transport Histone Deacetylase Activity, Hydrolytic Mechanism Bergmann Glial Cell Differentiation
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