IDH3A and SUMO4

Number of citations of the paper that reports this interaction (PubMedID 16236267)
0

Data Source:
HPRD (in vivo)

		IDH3A	SUMO4
Description		isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha	small ubiquitin like modifier 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Matrix Isocitrate Dehydrogenase Complex (NAD+)	Nucleus SUMO Ligase Complex
	Molecular Function	Magnesium Ion Binding Isocitrate Dehydrogenase (NAD+) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Metal Ion Binding NAD Binding	Protein Tag Activity Ubiquitin-like Protein Ligase Binding
	Biological Process	Carbohydrate Metabolic Process Tricarboxylic Acid Cycle Isocitrate Metabolic Process	Protein Sumoylation Cellular Response To Oxidative Stress Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of DNA Binding Negative Regulation Of DNA Binding Negative Regulation Of DNA-templated Transcription Regulation Of Protein Localization To Nucleus
Pathways		Citric acid cycle (TCA cycle) Mitochondrial protein degradation
Drugs		NADH Manganese Xanthinol Copper
Diseases
GWAS		Eyebrow thickness ( 26926045)	Dupuytren's disease ( 28886342)
Interacting Genes		7 interacting genes: IDH3B IDH3G MBNL1 PRPF6 RAB4A SF1 SUMO4	75 interacting genes: ACADM ACO2 ACTG1 ALDOA ARHGDIA ATP5F1B CALR CAT CCT2 CCT5 CCT6A CCT7 CLIC1 DNAJA1 DNAJB11 EIF3I ENO1 ENO2 FOS G6PD GAPDH GMPS GSTP1 HNRNPD HNRNPF HNRNPH1 HNRNPL HSPA1B HSPA5 HSPA8 HSPA9 HSPD1 IDH1 IDH3A IMPDH2 JUN LDHB LMNA LMNB1 MRPS22 NFKBIA NR3C1 PA2G4 PAFAH1B3 PDIA3 PDIA6 PGK1 PHB1 PHGDH PITHD1 PPA1 PRDX2 PRDX3 PRDX4 PRDX6 PRPS1 PSMC2 RACK1 RPSA SF3B4 SPINT2 STAT1 STAT3 STIP1 STOML2 STRAP TFAP2A TOP2A TPM3 TUBA1C TXNL1 UBE2V1 VCP VDAC1 ZPR1
Entrez ID		3419	387082
HPRD ID		03094	10584
Ensembl ID		ENSG00000166411	ENSG00000177688
Uniprot IDs		B4DJB4 B7Z9J8 P50213	Q6EEV6
PDB IDs		5GRE 5GRF 5GRH 5GRI 5GRL 5YVT 6KDE 6KDF 6KDY 6KE3 6L57 6L59 7CE3 8GRB 8GRD 8GRG 8GRH 8GRU 8GS5
Enriched GO Terms of Interacting Partners?		Isocitrate Dehydrogenase (NAD+) Activity Isocitrate Dehydrogenase Complex (NAD+) Isocitrate Metabolic Process Tricarboxylic Acid Metabolic Process Tricarboxylic Acid Cycle NAD Binding Spliceosomal Complex Assembly Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor RNA Splicing MRNA Processing Neurotransmitter Receptor Transport Postsynaptic Membrane To Endosome SUMO Ligase Complex MRNA Metabolic Process Insulin-responsive Compartment U2AF Complex MRNA 3'-splice Site Recognition Spliceosomal Complex Magnesium Ion Binding MRNA Splicing, Via Spliceosome Protein-RNA Complex Assembly RNA Splicing, Via Transesterification Reactions	Extracellular Exosome Protein Folding ATP-dependent Protein Folding Chaperone Unfolded Protein Binding Protein Folding Chaperone Cytoplasm Purine Nucleotide Metabolic Process Cytosol Nucleotide Metabolic Process Ubiquitin Protein Ligase Binding Ribose Phosphate Metabolic Process Regulation Of Apoptotic Process Ficolin-1-rich Granule Lumen Purine-containing Compound Metabolic Process Regulation Of Programmed Cell Death Identical Protein Binding RNA Binding Nucleoside Phosphate Metabolic Process Nicotinamide Nucleotide Metabolic Process Protein Refolding ATP Metabolic Process Secretory Granule Lumen Purine Ribonucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Peroxiredoxin Activity Ribonucleotide Metabolic Process Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Nucleobase-containing Compound Metabolic Process Cellular Response To Cytokine Stimulus Negative Regulation Of Programmed Cell Death Positive Regulation Of Telomerase RNA Localization To Cajal Body Mitochondrion Positive Regulation Of Telomere Maintenance Via Telomerase Oxidoreductase Activity Antioxidant Activity Positive Regulation Of Protein Localization To Cajal Body Chaperonin-containing T-complex Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Ribonucleoprotein Complex Small Molecule Metabolic Process Generation Of Precursor Metabolites And Energy Response To Peptide Enzyme Binding Regulation Of Telomerase RNA Localization To Cajal Body Peroxidase Activity Nucleus Hydrogen Peroxide Metabolic Process Response To Stress Organophosphate Metabolic Process
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