IDH3A and IDH3G

Number of citations of the paper that reports this interaction (PubMedID 40437099)
172

Data Source:
BioGRID (biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, cross-linking study, cross-linking study, biochemical)
HPRD (in vivo)

		IDH3A	IDH3G
Description		isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha	isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma
Image
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Matrix Isocitrate Dehydrogenase Complex (NAD+)	Nucleolus Mitochondrion Mitochondrial Matrix Isocitrate Dehydrogenase Complex (NAD+)
	Molecular Function	Magnesium Ion Binding Isocitrate Dehydrogenase (NAD+) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Metal Ion Binding NAD Binding	Nucleotide Binding Magnesium Ion Binding Isocitrate Dehydrogenase (NAD+) Activity Protein Binding ATP Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Metal Ion Binding NAD Binding
	Biological Process	Carbohydrate Metabolic Process Tricarboxylic Acid Cycle Isocitrate Metabolic Process	Carbohydrate Metabolic Process Tricarboxylic Acid Cycle Isocitrate Metabolic Process
Pathways		Citric acid cycle (TCA cycle) Mitochondrial protein degradation	Mitochondrial protein import Citric acid cycle (TCA cycle)
Drugs		NADH Manganese Xanthinol Copper	NADH Manganese
Diseases
GWAS		Eyebrow thickness ( 26926045)
Interacting Genes		7 interacting genes: IDH3B IDH3G MBNL1 PRPF6 RAB4A SF1 SUMO4	3 interacting genes: ERCC6 IDH3A IDH3B
Entrez ID		3419	3421
HPRD ID		03094	02100
Ensembl ID		ENSG00000166411	ENSG00000067829
Uniprot IDs		B4DJB4 B7Z9J8 P50213	O15384 P51553
PDB IDs		5GRE 5GRF 5GRH 5GRI 5GRL 5YVT 6KDE 6KDF 6KDY 6KE3 6L57 6L59 7CE3 8GRB 8GRD 8GRG 8GRH 8GRU 8GS5	5GRE 5GRF 5GRH 5GRI 5GRL 5YVT 6L57 6L59 7CE3 8GRG 8GRH 8GS5
Enriched GO Terms of Interacting Partners?		Isocitrate Dehydrogenase (NAD+) Activity Isocitrate Dehydrogenase Complex (NAD+) Isocitrate Metabolic Process Tricarboxylic Acid Metabolic Process Tricarboxylic Acid Cycle NAD Binding Spliceosomal Complex Assembly Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor RNA Splicing MRNA Processing Neurotransmitter Receptor Transport Postsynaptic Membrane To Endosome SUMO Ligase Complex MRNA Metabolic Process Insulin-responsive Compartment U2AF Complex MRNA 3'-splice Site Recognition Spliceosomal Complex Magnesium Ion Binding MRNA Splicing, Via Spliceosome Protein-RNA Complex Assembly RNA Splicing, Via Transesterification Reactions	Isocitrate Dehydrogenase (NAD+) Activity Isocitrate Dehydrogenase Complex (NAD+) Isocitrate Metabolic Process Tricarboxylic Acid Metabolic Process Tricarboxylic Acid Cycle NAD Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Magnesium Ion Binding Alcohol Metabolic Process DNA Protection Transcription Elongation By RNA Polymerase I Response To Superoxide Response To Oxygen Radical B-WICH Complex Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Pyrimidine Dimer Repair Mitochondrial Matrix Double-strand Break Repair Via Classical Nonhomologous End Joining Single Strand Break Repair Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Transcription By RNA Polymerase III ATP-dependent Chromatin Remodeler Activity RNA Polymerase Binding ATP-dependent DNA Damage Sensor Activity Protein Tyrosine Kinase Activator Activity Chromatin-protein Adaptor Activity Transcription Elongation Factor Complex Positive Regulation Of Peptidyl-serine Phosphorylation Response To UV-B Regulation Of Peptidyl-serine Phosphorylation Regulation Of Transcription By RNA Polymerase III Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Transcription By RNA Polymerase I Response To X-ray ATP-dependent Activity, Acting On DNA Organic Acid Metabolic Process Carboxylic Acid Metabolic Process Positive Regulation Of Defense Response To Virus By Host Base-excision Repair DNA Helicase Activity Negative Regulation Of DNA Repair Site Of DNA Damage Photoreceptor Cell Maintenance Regulation Of Transcription By RNA Polymerase I Negative Regulation Of Double-strand Break Repair Regulation Of Defense Response To Virus By Host Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Nucleotide-excision Repair Response To Gamma Radiation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?