ACADM and DYNC1I1

Number of citations: 84 (PubMedID 34133714)
Data Source: BioGRID (two hybrid)

		ACADM	DYNC1I1
Name		acyl-CoA dehydrogenase medium chain	dynein cytoplasmic 1 intermediate chain 1
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Axon Mitochondrial Membrane	Chromosome, Centromeric Region Kinetochore Spindle Pole Nucleus Chromosome Cytoplasm Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Dynein Complex Vesicle Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Acyl-CoA Dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Identical Protein Binding Flavin Adenine Dinucleotide Binding Medium-chain Fatty Acyl-CoA Dehydrogenase Activity	Cytoskeletal Motor Activity Microtubule Motor Activity Protein Binding Microtubule Binding Spectrin Binding Dynein Light Chain Binding Dynein Heavy Chain Binding
	Biological Process	Liver Development Glycogen Biosynthetic Process Organic Acid Metabolic Process Regulation Of Gluconeogenesis Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Heart Development Response To Cold Carnitine Metabolic Process Post-embryonic Development Carnitine Metabolic Process, CoA-linked Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase Response To Starvation Carnitine Biosynthetic Process Medium-chain Fatty Acid Metabolic Process Medium-chain Fatty Acid Catabolic Process Cardiac Muscle Cell Differentiation	Microtubule-based Movement Transport Along Microtubule Vesicle Transport Along Microtubule
Pathways		PPARA activates gene expression mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs		Octanoyl-Coenzyme A Flavin adenine dinucleotide 3-thiaoctanoyl-CoA	None
Diseases		Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP)	None
GWAS		Daytime sleep phenotypes ( 27126917 ) Glycine levels ( 30837465 31070104 ) Metabolic traits ( 21886157 ) Metabolite levels ( 20037589 ) Serum metabolite concentrations in chronic kidney disease ( 29545352 ) Serum metabolite levels ( 23093944 33031748 ) Serum metabolite ratios in chronic kidney disease ( 29545352 ) Urinary metabolite levels in chronic kidney disease ( 31959995 ) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995 )	Dementia and core Alzheimer's disease neuropathologic changes ( 25188341 ) Heel bone mineral density ( 30598549 ) Hip circumference adjusted for BMI ( 28552196 ) Immune reponse to smallpox (secreted IL-10) ( 22610502 ) Knee osteoarthritis ( 27696742 ) Multisite chronic pain ( 31194737 33830993 ) Obesity-related traits ( 23251661 ) Oily fish consumption ( 32066663 ) Pork consumption ( 32066663 ) Refractive error ( 32231278 )
Novel Interactors		5 novel interactors: ABCD3 AGTR1 DBT DIRAS3 MSH4	9 novel interactors: DDX19B KLC2 MCM7 NDUFV2 NPTX2 NUP214 SEM1 SERPINE1 ZKSCAN1
Interacting Genes		5 interacting genes: CALM1 CDC42 DYNC1I1 PANK1 SUMO4	35 interacting genes: ACADM ANXA7 BICD1 CADM4 CDKN1A DCTN1 DNM2 DYNLL1 DYNLL2 DYNLRB1 DYNLT1 DYNLT3 EMILIN1 FAM110A FAM83D FBP1 GRB7 GSK3B KAT7 LCOR MCC NAGK NUDT21 PIN1 RAP1GAP RBPMS RCC1 RUNDC3B SMN1 STAU1 TAOK1 TK1 TRIM58 WDCP YTHDF1
Entrez ID		34	1780
HPRD ID		08447	04798
Ensembl ID		ENSG00000117054	ENSG00000158560
Uniprot IDs		A0A0S2Z366 B4DJE7 B7Z9I1 P11310 Q5T4U5	A4D1I7 O14576 Q8N542
PDB IDs		1EGC 1EGD 1EGE 1T9G 2A1T 4P13 8SGP	Not available
GO Terms Enriched among Interactors		Intracellular Signaling Cassette Small GTPase-mediated Signal Transduction Angiotensin Type I Receptor Activity Bradykinin Receptor Binding Substantia Nigra Development Negative Regulation Of High Voltage-gated Calcium Channel Activity Neural Nucleus Development Regulation Of Cytokinesis Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Type II Interferon Cytoplasmic Ribonucleoprotein Granule GBD Domain Binding Storage Vacuole Organelle Transport Along Microtubule Dihydrolipoamide Branched Chain Acyltransferase Activity Recombination Nodule Phytanic Acid Metabolic Process Pantothenate Kinase Activity Angiotensin Type II Receptor Activity Phospholipase C-activating Angiotensin-activated Signaling Pathway Renin-angiotensin Regulation Of Aldosterone Production Organelle Localization Response To Type II Interferon Nucleotide Binding Apolipoprotein A-I Receptor Binding Endothelin Receptor Signaling Pathway Involved In Heart Process Neuropilin Signaling Pathway Branched-chain Alpha-keto Acid Decarboxylation To Branched-chain Acyl-CoA Branched-chain Alpha-ketoacid Dehydrogenase Complex Methyl-branched Fatty Acid Metabolic Process Long-chain Fatty Acid Import Into Peroxisome Acetyl-CoA Binding SUMO Ligase Complex	Dynein Intermediate Chain Binding Dynein Complex Cytoplasmic Dynein Complex Microtubule-based Process Microtubule Microtubule Associated Complex Tau Protein Binding Cytoplasmic Stress Granule Microtubule-based Movement Centrosome Regulation Of Microtubule-based Process Regulation Of Microtubule Cytoskeleton Organization Regulation Of Intracellular Transport Stress Granule Assembly Identical Protein Binding Microtubule Cytoskeleton Organization Positive Regulation Of Protein Localization To Centrosome Cellular Component Assembly Regulation Of Long-term Synaptic Potentiation Cytoplasm Secretory Vesicle Regulation Of DNA Replication Ciliary Tip Regulation Of Cell Cycle Microtubule Cytoskeleton Organization Involved In Mitosis Response To Phorbol 13-acetate 12-myristate Intracellular MRNA Localization Regulation Of Protein Localization To Centrosome Positive Regulation Of Intracellular Transport Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway MRNA Binding Microtubule Anchoring At Microtubule Organizing Center Microtubule Cytoskeleton Viral Process Mitotic Cell Cycle Phase Transition Dynactin Binding Replicative Senescence Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway MRNA Export From Nucleus Membraneless Organelle Assembly Regulation Of DNA-templated DNA Replication Initiation Regulation Of Cellular Component Organization Negative Regulation Of Phosphate Metabolic Process Cell Cycle Phase Transition Scaffold Protein Binding Negative Regulation Of Cellular Response To Vascular Endothelial Growth Factor Stimulus Cytoskeleton Protein Kinase Binding Transport Along Microtubule Organelle Localization