ACADM and PANK1

Number of citations: 84 (PubMedID 34133714)
Data Source: BioGRID (two hybrid)

		ACADM	PANK1
Name		acyl-CoA dehydrogenase medium chain	pantothenate kinase 1
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Axon Mitochondrial Membrane	Nucleus Nucleolus Cytoplasm Endosome Cytosol Clathrin-coated Vesicle Cytoplasmic Vesicle Recycling Endosome
	Molecular Function	Acyl-CoA Dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Identical Protein Binding Flavin Adenine Dinucleotide Binding Medium-chain Fatty Acyl-CoA Dehydrogenase Activity	Nucleotide Binding Pantothenate Kinase Activity ATP Binding Kinase Activity Transferase Activity Protein Homodimerization Activity Acetyl-CoA Binding
	Biological Process	Liver Development Glycogen Biosynthetic Process Organic Acid Metabolic Process Regulation Of Gluconeogenesis Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Heart Development Response To Cold Carnitine Metabolic Process Post-embryonic Development Carnitine Metabolic Process, CoA-linked Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase Response To Starvation Carnitine Biosynthetic Process Medium-chain Fatty Acid Metabolic Process Medium-chain Fatty Acid Catabolic Process Cardiac Muscle Cell Differentiation	Coenzyme A Biosynthetic Process
Pathways		PPARA activates gene expression mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA	Coenzyme A biosynthesis
Drugs		Octanoyl-Coenzyme A Flavin adenine dinucleotide 3-thiaoctanoyl-CoA	None
Diseases		Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP)	None
GWAS		Daytime sleep phenotypes ( 27126917 ) Glycine levels ( 30837465 31070104 ) Metabolic traits ( 21886157 ) Metabolite levels ( 20037589 ) Serum metabolite concentrations in chronic kidney disease ( 29545352 ) Serum metabolite levels ( 23093944 33031748 ) Serum metabolite ratios in chronic kidney disease ( 29545352 ) Urinary metabolite levels in chronic kidney disease ( 31959995 ) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995 )	Distal colorectal cancer ( 33632709 ) Distal/Left-sided colorectal cancer ( 33632709 ) Metabolic traits ( 19060910 ) Plateletcrit ( 32888494 )
Novel Interactors		5 novel interactors: ABCD3 AGTR1 DBT DIRAS3 MSH4	1 novel interactors: SLAMF7
Interacting Genes		5 interacting genes: CALM1 CDC42 DYNC1I1 PANK1 SUMO4	2 interacting genes: ACADM YWHAQ
Entrez ID		34	53354
HPRD ID		08447	07549
Ensembl ID		ENSG00000117054	ENSG00000152782
Uniprot IDs		A0A0S2Z366 B4DJE7 B7Z9I1 P11310 Q5T4U5	A0A8C8KBT8 Q8TE04
PDB IDs		1EGC 1EGD 1EGE 1T9G 2A1T 4P13 8SGP	2I7N 3SMP
GO Terms Enriched among Interactors		Intracellular Signaling Cassette Small GTPase-mediated Signal Transduction Angiotensin Type I Receptor Activity Bradykinin Receptor Binding Substantia Nigra Development Negative Regulation Of High Voltage-gated Calcium Channel Activity Neural Nucleus Development Regulation Of Cytokinesis Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Type II Interferon Cytoplasmic Ribonucleoprotein Granule GBD Domain Binding Storage Vacuole Organelle Transport Along Microtubule Dihydrolipoamide Branched Chain Acyltransferase Activity Recombination Nodule Phytanic Acid Metabolic Process Pantothenate Kinase Activity Angiotensin Type II Receptor Activity Phospholipase C-activating Angiotensin-activated Signaling Pathway Renin-angiotensin Regulation Of Aldosterone Production Organelle Localization Response To Type II Interferon Nucleotide Binding Apolipoprotein A-I Receptor Binding Endothelin Receptor Signaling Pathway Involved In Heart Process Neuropilin Signaling Pathway Branched-chain Alpha-keto Acid Decarboxylation To Branched-chain Acyl-CoA Branched-chain Alpha-ketoacid Dehydrogenase Complex Methyl-branched Fatty Acid Metabolic Process Long-chain Fatty Acid Import Into Peroxisome Acetyl-CoA Binding SUMO Ligase Complex	Carnitine Metabolic Process, CoA-linked Medium-chain Fatty Acyl-CoA Dehydrogenase Activity Medium-chain Fatty Acid Catabolic Process Carnitine Biosynthetic Process Identical Protein Binding Carnitine Metabolic Process Medium-chain Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase Acyl-CoA Dehydrogenase Activity Glycogen Biosynthetic Process Amino-acid Betaine Metabolic Process Polysaccharide Biosynthetic Process Oxidoreductase Activity, Acting On The CH-CH Group Of Donors