DYNC1I1 and NDUFV2

		DYNC1I1	NDUFV2
Description		dynein cytoplasmic 1 intermediate chain 1	NADH:ubiquinone oxidoreductase core subunit V2
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Spindle Pole Nucleus Chromosome Cytoplasm Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Dynein Complex Vesicle Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm Recycling Endosome	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex I
	Molecular Function	Cytoskeletal Motor Activity Microtubule Motor Activity Protein Binding Microtubule Binding Spectrin Binding Dynein Light Chain Binding Dynein Heavy Chain Binding	NADH Dehydrogenase Activity Protein Binding NADH Dehydrogenase (ubiquinone) Activity Electron Transfer Activity Oxidoreductase Activity Metal Ion Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Microtubule-based Movement Transport Along Microtubule Vesicle Transport Along Microtubule	Mitochondrial Electron Transport, NADH To Ubiquinone Nervous System Development Aerobic Respiration Proton Motive Force-driven Mitochondrial ATP Synthesis Cardiac Muscle Tissue Development Proton Transmembrane Transport
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation	Respiratory electron transport Complex I biogenesis
Drugs			NADH
Diseases			Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 28552196) Immune reponse to smallpox (secreted IL-10) ( 22610502) Knee osteoarthritis ( 27696742) Multisite chronic pain ( 31194737 33830993) Obesity-related traits ( 23251661) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Refractive error ( 32231278)	Cerebral amyloid deposition (PET imaging) ( 26252872) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Platelet distribution width ( 32888494) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		35 interacting genes: ACADM ANXA7 BICD1 CADM4 CDKN1A DCTN1 DNM2 DYNLL1 DYNLL2 DYNLRB1 DYNLT1 DYNLT3 EMILIN1 FAM110A FAM83D FBP1 GRB7 GSK3B KAT7 LCOR MCC NAGK NUDT21 PIN1 RAP1GAP RBPMS RCC1 RUNDC3B SMN1 STAU1 TAOK1 TK1 TRIM58 WDCP YTHDF1	5 interacting genes: CRMP1 FAM114A2 GOLM1 KAT5 SP110
Entrez ID		1780	4729
HPRD ID		04798	02757
Ensembl ID		ENSG00000158560	ENSG00000178127
Uniprot IDs		A4D1I7 O14576 Q8N542	P19404
PDB IDs			5XTB 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?		Dynein Intermediate Chain Binding Dynein Complex Cytoplasmic Dynein Complex Microtubule-based Process Microtubule Microtubule Associated Complex Tau Protein Binding Cytoplasmic Stress Granule Microtubule-based Movement Centrosome Regulation Of Microtubule-based Process Regulation Of Microtubule Cytoskeleton Organization Regulation Of Intracellular Transport Stress Granule Assembly Identical Protein Binding Microtubule Cytoskeleton Organization Positive Regulation Of Protein Localization To Centrosome Cellular Component Assembly Regulation Of Long-term Synaptic Potentiation Cytoplasm Secretory Vesicle Regulation Of DNA Replication Ciliary Tip Regulation Of Cell Cycle Microtubule Cytoskeleton Organization Involved In Mitosis Response To Phorbol 13-acetate 12-myristate Intracellular MRNA Localization Regulation Of Protein Localization To Centrosome Positive Regulation Of Intracellular Transport Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway MRNA Binding Microtubule Anchoring At Microtubule Organizing Center Microtubule Cytoskeleton Viral Process Mitotic Cell Cycle Phase Transition Dynactin Binding Replicative Senescence Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway MRNA Export From Nucleus Membraneless Organelle Assembly Regulation Of DNA-templated DNA Replication Initiation Regulation Of Cellular Component Organization Negative Regulation Of Phosphate Metabolic Process Cell Cycle Phase Transition Scaffold Protein Binding Negative Regulation Of Cellular Response To Vascular Endothelial Growth Factor Stimulus Cytoskeleton Protein Kinase Binding Transport Along Microtubule Organelle Localization	Pyrimidine-containing Compound Metabolic Process Nuclear Lumen Transferase Activity, Transferring One-carbon Groups Thymidylate Synthase Activity Histone H2AK5 Acetyltransferase Activity
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