ACADM and MSH4

Data Source: HiPPIP (Novel)

		ACADM	MSH4
Name		acyl-CoA dehydrogenase medium chain	mutS homolog 4
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Axon Mitochondrial Membrane	Condensed Chromosome Condensed Nuclear Chromosome Synaptonemal Complex Nucleus Chromosome Recombination Nodule
	Molecular Function	Acyl-CoA Dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Identical Protein Binding Flavin Adenine Dinucleotide Binding Medium-chain Fatty Acyl-CoA Dehydrogenase Activity	Nucleotide Binding DNA Binding Double-stranded DNA Binding Protein Binding ATP Binding Mismatched DNA Binding ATP-dependent DNA Damage Sensor Activity
	Biological Process	Liver Development Glycogen Biosynthetic Process Organic Acid Metabolic Process Regulation Of Gluconeogenesis Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Heart Development Response To Cold Carnitine Metabolic Process Post-embryonic Development Carnitine Metabolic Process, CoA-linked Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase Response To Starvation Carnitine Biosynthetic Process Medium-chain Fatty Acid Metabolic Process Medium-chain Fatty Acid Catabolic Process Cardiac Muscle Cell Differentiation	Ovarian Follicle Development Mismatch Repair Homologous Chromosome Pairing At Meiosis Reciprocal Meiotic Recombination Spermatogenesis Female Gamete Generation Meiotic Cell Cycle
Pathways		PPARA activates gene expression mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA	Meiotic recombination
Drugs		Octanoyl-Coenzyme A Flavin adenine dinucleotide 3-thiaoctanoyl-CoA	None
Diseases		Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP)	None
GWAS		Daytime sleep phenotypes ( 27126917 ) Glycine levels ( 30837465 31070104 ) Metabolic traits ( 21886157 ) Metabolite levels ( 20037589 ) Serum metabolite concentrations in chronic kidney disease ( 29545352 ) Serum metabolite levels ( 23093944 33031748 ) Serum metabolite ratios in chronic kidney disease ( 29545352 ) Urinary metabolite levels in chronic kidney disease ( 31959995 ) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995 )	Attention function in attention deficit hyperactive disorder ( 26174813 ) Daytime sleep phenotypes ( 27126917 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Serum metabolite levels ( 23093944 )
Novel Interactors		5 novel interactors: ABCD3 AGTR1 DBT DIRAS3 MSH4	1 novel interactors: ACADM
Interacting Genes		5 interacting genes: CALM1 CDC42 DYNC1I1 PANK1 SUMO4	9 interacting genes: CFTR DMC1 EIF3F MLH1 MLH3 MSH5 RAD51 RPA1 VBP1
Entrez ID		34	4438
HPRD ID		08447	03658
Ensembl ID		ENSG00000117054	ENSG00000057468
Uniprot IDs		A0A0S2Z366 B4DJE7 B7Z9I1 P11310 Q5T4U5	O15457
PDB IDs		1EGC 1EGD 1EGE 1T9G 2A1T 4P13 8SGP	Not available
GO Terms Enriched among Interactors		Intracellular Signaling Cassette Small GTPase-mediated Signal Transduction Angiotensin Type I Receptor Activity Bradykinin Receptor Binding Substantia Nigra Development Negative Regulation Of High Voltage-gated Calcium Channel Activity Neural Nucleus Development Regulation Of Cytokinesis Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Type II Interferon Cytoplasmic Ribonucleoprotein Granule GBD Domain Binding Storage Vacuole Organelle Transport Along Microtubule Dihydrolipoamide Branched Chain Acyltransferase Activity Recombination Nodule Phytanic Acid Metabolic Process Pantothenate Kinase Activity Angiotensin Type II Receptor Activity Phospholipase C-activating Angiotensin-activated Signaling Pathway Renin-angiotensin Regulation Of Aldosterone Production Organelle Localization Response To Type II Interferon Nucleotide Binding Apolipoprotein A-I Receptor Binding Endothelin Receptor Signaling Pathway Involved In Heart Process Neuropilin Signaling Pathway Branched-chain Alpha-keto Acid Decarboxylation To Branched-chain Acyl-CoA Branched-chain Alpha-ketoacid Dehydrogenase Complex Methyl-branched Fatty Acid Metabolic Process Long-chain Fatty Acid Import Into Peroxisome Acetyl-CoA Binding SUMO Ligase Complex	ATP-dependent DNA Damage Sensor Activity Condensed Nuclear Chromosome Meiosis I Cell Cycle Process Meiotic Nuclear Division Nuclear Division Reciprocal Meiotic Recombination Mismatch Repair Condensed Chromosome Meiotic Cell Cycle Homologous Recombination Meiosis I Male Germ Cell Nucleus Chromosome Organization Involved In Meiotic Cell Cycle Mismatched DNA Binding Lateral Element DNA Recombination DNA Repair Chiasma DNA Strand Exchange Activity Single-stranded DNA Binding Chromosome Organization DNA Metabolic Process DNA Damage Response Reproductive Process Male Meiotic Nuclear Division Mismatch Repair Complex DNA Strand Invasion DNA Recombinase Assembly Cellular Response To Stress Double-strand Break Repair Double-strand Break Repair Involved In Meiotic Recombination Site Of Double-strand Break Response To Stress ATP Binding Double-stranded DNA Binding Mitotic Recombination Double-strand Break Repair Via Homologous Recombination Recombinational Repair Synaptonemal Complex Cellular Component Assembly Homologous Chromosome Pairing At Meiosis Chromatin Binding Chromosome, Telomeric Region Telomere Maintenance Via Telomere Lengthening Nuclear Chromosome ATP-dependent Activity, Acting On DNA Oogenesis Nucleic Acid Metabolic Process Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity