HUS1 and FEN1

Number of citations: 53 (PubMedID 30184152)
Data Source: BioGRID (pull down, pull down, affinity chromatography technology, affinity chromatography technology)

		HUS1	FEN1
Name		HUS1 checkpoint clamp component	flap structure-specific endonuclease 1
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Checkpoint Clamp Complex Site Of Double-strand Break	Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Mitochondrion Membrane Protein-containing Complex
	Molecular Function	Protein Binding	Magnesium Ion Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Catalytic Activity Nuclease Activity Endonuclease Activity DNA Endonuclease Activity RNA-DNA Hybrid Ribonuclease Activity Exonuclease Activity Protein Binding Double-stranded DNA Exodeoxyribonuclease Activity 5'-3' Exonuclease Activity Hydrolase Activity Hydrolase Activity, Acting On Ester Bonds 5'-flap Endonuclease Activity Manganese Ion Binding Metal Ion Binding Flap Endonuclease Activity
	Biological Process	DNA Damage Checkpoint Signaling Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Repair Nucleotide-excision Repair DNA Damage Response Response To Radiation Response To UV Embryo Development Ending In Birth Or Egg Hatching Mitotic Intra-S DNA Damage Checkpoint Signaling Mitotic DNA Replication Checkpoint Signaling Meiotic DNA Integrity Checkpoint Signaling Cellular Response To Ionizing Radiation	Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Base-excision Repair Base-excision Repair, Gap-filling Double-strand Break Repair DNA Recombination DNA Damage Response Memory UV Protection Telomere Maintenance Via Semi-conservative Replication DNA Replication, Removal Of RNA Primer Positive Regulation Of Sister Chromatid Cohesion
Pathways		Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51	POLB-Dependent Long Patch Base Excision Repair Early Phase of HIV Life Cycle Removal of the Flap Intermediate from the C-strand PCNA-Dependent Long Patch Base Excision Repair HDR through MMEJ (alt-NHEJ) Removal of the Flap Intermediate
Drugs		None	Iron Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
GWAS		Gut microbiota alpha diversity (Shannon index) ( 33208821 ) Obstructive sleep apnea during REM sleep (apnea hypopnea index) ( 29077507 )	Asthma ( 31619474 31959851 ) Bipolar disorder ( 28115744 31043756 ) Bipolar I disorder ( 31043756 ) Brain morphology (MOSTest) ( 32665545 ) Colorectal cancer ( 24836286 ) Colorectal cancer or advanced adenoma ( 30510241 ) Crohn's disease ( 28067908 ) Daytime nap ( 33568662 ) Delta-5 desaturase activity response to n3-polyunsaturated fat supplement ( 29246731 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Hemoglobin levels ( 32327693 ) Laryngeal squamous cell carcinoma ( 25194280 ) Male-pattern baldness ( 28196072 ) Metabolite levels ( 23378610 23823483 ) Oleic acid (18:1n-9) levels ( 23362303 ) Palmitoleic acid (16:1n-7) levels ( 23362303 ) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377 ) Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid) ( 21829377 ) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377 ) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311 ) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311 ) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311 ) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311 ) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311 ) Platelet count ( 22139419 ) QT interval ( 29874175 ) Red blood cell fatty acid levels ( 25500335 ) Refractive error ( 32231278 ) Resting heart rate ( 27798624 ) Serum metabolite levels ( 23093944 ) Serum metabolite ratios in chronic kidney disease ( 29545352 ) Stearic acid (18:0) levels ( 23362303 )
Interacting Genes		28 interacting genes: C4orf46 CD200 DCUN1D5 DNAJC7 FEN1 GRIP1 HDAC1 HUS1B MSH2 MSH3 MSH6 NEIL1 NTAQ1 OGG1 PCNA POLB RAD1 RAD17 RAD9A RAD9B RHNO1 RPA1 RPA2 SDCBP SIRT6 TDG TOPBP1 YWHAQ	20 interacting genes: APEX1 APP ARHGDIA BLM CCNA2 CDK1 CDK2 CEBPA EEF1G EP300 GSK3B HNRNPA1 HUS1 OGT PCNA RAD1 RAD9A TERF1 WDR4 WRN
Entrez ID		3364	2237
HPRD ID		04787	02670
Ensembl ID		ENSG00000136273	ENSG00000168496
Uniprot IDs		A4D2F2 O60921	P39748 Q6FHX6
PDB IDs		3A1J 3G65 3GGR 6J8Y 7Z6H 8GNN 8WU8	1U7B 1UL1 3Q8K 3Q8L 3Q8M 3UVU 5E0V 5FV7 5K97 5KSE 5UM9 5ZOD 5ZOE 5ZOF 5ZOG 6TNZ 7QO1 8YJH 8YJL 8YJQ 8YJR 8YJS 8YJU 8YJV 8YJW 8YJZ
GO Terms Enriched among Interactors		DNA Repair Damaged DNA Binding DNA Damage Response DNA Metabolic Process Base-excision Repair Cellular Response To Stress DNA Damage Checkpoint Signaling Response To Radiation Signal Transduction In Response To DNA Damage DNA Recombination Nucleic Acid Metabolic Process Mismatch Repair Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Checkpoint Clamp Complex Mitotic Intra-S DNA Damage Checkpoint Signaling Double-strand Break Repair Negative Regulation Of Cell Cycle Phase Transition DNA Replication Checkpoint Signaling Site Of Double-strand Break Oxidized Purine DNA Binding Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process Protein Localization To Site Of Double-strand Break Response To Stress Mismatched DNA Binding Chromosome Organization Response To Ionizing Radiation Negative Regulation Of Cell Cycle Single Guanine Insertion Binding Dinucleotide Insertion Or Deletion Binding Base-excision Repair, Gap-filling Nucleoplasm Chromosome, Telomeric Region Guanine/thymine Mispair Binding Intracellular Signal Transduction Chromatin-protein Adaptor Activity Protein Localization To Chromosome Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Macromolecule Metabolic Process Recombinational Repair Regulation Of Cell Cycle Process Maintenance Of DNA Repeat Elements MutLalpha Complex Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Response To UV Nucleus Enzyme Binding Depyrimidination	Cellular Response To Stress Telomere Maintenance Telomere Organization Nucleic Acid Metabolic Process DNA Damage Response Response To Stress Macromolecule Metabolic Process Cellular Response To Radiation Chromosome, Telomeric Region DNA Damage Checkpoint Signaling Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Metabolic Process Chromosome Organization Nucleus DNA Repair Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Intracellular Signal Transduction Nucleoplasm Mitotic DNA Damage Checkpoint Signaling Checkpoint Clamp Complex Response To Radiation Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle Process Signal Transduction In Response To DNA Damage Cellular Response To Ionizing Radiation Positive Regulation Of DNA Metabolic Process Double-stranded DNA 3'-5' DNA Exonuclease Activity Regulation Of DNA Metabolic Process Telomere Maintenance Via Semi-conservative Replication Regulation Of Cell Cycle Telomeric D-loop Disassembly Negative Regulation Of Cell Cycle Phase Transition Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of DNA Replication Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Oxygen-containing Compound Telomeric Loop Disassembly T-circle Formation Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Macromolecule Metabolic Process Response To Ionizing Radiation Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process DNA Replication 3'-5' Exonuclease Activity Damaged DNA Binding Regulation Of Mitotic Cell Cycle Negative Regulation Of Metabolic Process Forked DNA-dependent Helicase Activity