HUS1 and RHNO1

Number of citations of the paper that reports this interaction (PubMedID 31776186)
25

Data Source:
BioGRID (pull down)

		HUS1	RHNO1
Description		HUS1 checkpoint clamp component	RAD9-HUS1-RAD1 interacting nuclear orphan 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Checkpoint Clamp Complex Site Of Double-strand Break	Chromatin Nucleus Nucleoplasm Chromosome Site Of Double-strand Break
	Molecular Function	Protein Binding	Protein Binding Chromatin-protein Adaptor Activity
	Biological Process	DNA Damage Checkpoint Signaling Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Repair Nucleotide-excision Repair DNA Damage Response Response To Radiation Response To UV Embryo Development Ending In Birth Or Egg Hatching Mitotic Intra-S DNA Damage Checkpoint Signaling Mitotic DNA Replication Checkpoint Signaling Meiotic DNA Integrity Checkpoint Signaling Cellular Response To Ionizing Radiation	DNA Damage Checkpoint Signaling Recombinational Repair DNA Repair Chromatin Organization DNA Damage Response Cellular Response To UV Positive Regulation Of G0 To G1 Transition Cellular Response To Ionizing Radiation Double-strand Break Repair Via Alternative Nonhomologous End Joining Protein Localization To Site Of Double-strand Break
Pathways		Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51	HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS		Gut microbiota alpha diversity (Shannon index) ( 33208821) Obstructive sleep apnea during REM sleep (apnea hypopnea index) ( 29077507)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		28 interacting genes: C4orf46 CD200 DCUN1D5 DNAJC7 FEN1 GRIP1 HDAC1 HUS1B MSH2 MSH3 MSH6 NEIL1 NTAQ1 OGG1 PCNA POLB RAD1 RAD17 RAD9A RAD9B RHNO1 RPA1 RPA2 SDCBP SIRT6 TDG TOPBP1 YWHAQ	11 interacting genes: BANP CYSRT1 GOLGA2 HUS1 KRTAP10-3 KRTAP10-8 KRTAP10-9 LZTS2 RAD1 RAD9A TFIP11
Entrez ID		3364	83695
HPRD ID		04787	17487
Ensembl ID		ENSG00000136273	ENSG00000171792
Uniprot IDs		A4D2F2 O60921	Q9BSD3
PDB IDs		3A1J 3G65 3GGR 6J8Y 7Z6H 8GNN 8WU8	6J8Y 8WU8
Enriched GO Terms of Interacting Partners?		DNA Repair Damaged DNA Binding DNA Damage Response DNA Metabolic Process Base-excision Repair Cellular Response To Stress DNA Damage Checkpoint Signaling Response To Radiation Signal Transduction In Response To DNA Damage DNA Recombination Nucleic Acid Metabolic Process Mismatch Repair Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Checkpoint Clamp Complex Mitotic Intra-S DNA Damage Checkpoint Signaling Double-strand Break Repair Negative Regulation Of Cell Cycle Phase Transition DNA Replication Checkpoint Signaling Site Of Double-strand Break Oxidized Purine DNA Binding Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process Protein Localization To Site Of Double-strand Break Response To Stress Mismatched DNA Binding Chromosome Organization Response To Ionizing Radiation Negative Regulation Of Cell Cycle Single Guanine Insertion Binding Dinucleotide Insertion Or Deletion Binding Base-excision Repair, Gap-filling Nucleoplasm Chromosome, Telomeric Region Guanine/thymine Mispair Binding Intracellular Signal Transduction Chromatin-protein Adaptor Activity Protein Localization To Chromosome Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Macromolecule Metabolic Process Recombinational Repair Regulation Of Cell Cycle Process Maintenance Of DNA Repeat Elements MutLalpha Complex Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Response To UV Nucleus Enzyme Binding Depyrimidination	Checkpoint Clamp Complex Double-stranded DNA 3'-5' DNA Exonuclease Activity Cellular Response To Ionizing Radiation Meiotic Cell Cycle Checkpoint Signaling Keratin Filament DNA Damage Checkpoint Signaling Mitotic Intra-S DNA Damage Checkpoint Signaling DNA Replication Checkpoint Signaling Response To Ionizing Radiation Signal Transduction In Response To DNA Damage Intermediate Filament Cellular Response To Radiation Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Process Primary Ureteric Bud Growth Mitotic DNA Integrity Checkpoint Signaling DNA Metabolic Process Mitotic DNA Damage Checkpoint Signaling DNA Damage Response Negative Regulation Of Cell Cycle Meiotic DNA Integrity Checkpoint Signaling Spliceosomal Complex Disassembly Telomere Maintenance Meiotic Recombination Checkpoint Signaling U2-type Post-mRNA Release Spliceosomal Complex Response To Radiation Regulation Of Cell Cycle Phase Transition Positive Regulation Of Protein Glycosylation Telomere Organization DNA Repair Golgi Disassembly Regulation Of Protein Glycosylation Protection From Non-homologous End Joining At Telomere Ureter Morphogenesis Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Importin-alpha Family Protein Binding Negative Regulation Of Meiotic Nuclear Division Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Microtubule Severing Golgi Ribbon Formation Mitotic DNA Replication Checkpoint Signaling Golgi Cis Cisterna Negative Regulation Of Mitotic Cell Cycle Spindle Midzone Assembly
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