HUS1 and DCUN1D5

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		HUS1	DCUN1D5
Name		HUS1 checkpoint clamp component	defective in cullin neddylation 1 domain containing 5
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Checkpoint Clamp Complex Site Of Double-strand Break	Ubiquitin Ligase Complex Nucleus Cytoplasm Spindle Cytoskeleton
	Molecular Function	Protein Binding	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Binding Cullin Family Protein Binding
	Biological Process	DNA Damage Checkpoint Signaling Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Repair Nucleotide-excision Repair DNA Damage Response Response To Radiation Response To UV Embryo Development Ending In Birth Or Egg Hatching Mitotic Intra-S DNA Damage Checkpoint Signaling Mitotic DNA Replication Checkpoint Signaling Meiotic DNA Integrity Checkpoint Signaling Cellular Response To Ionizing Radiation	Regulation Of Cell Growth DNA Damage Response Protein Neddylation Regulation Of Protein Neddylation Positive Regulation Of Protein Neddylation
Pathways		Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51	Neddylation
GWAS		Gut microbiota alpha diversity (Shannon index) ( 33208821 ) Obstructive sleep apnea during REM sleep (apnea hypopnea index) ( 29077507 )	Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798 ) Diisocyanate-induced asthma ( 25918132 ) Interleukin-10 levels ( 22205395 ) Toenail selenium levels ( 25343990 ) Tuberculosis ( 24057671 )
Interacting Genes		28 interacting genes: C4orf46 CD200 DCUN1D5 DNAJC7 FEN1 GRIP1 HDAC1 HUS1B MSH2 MSH3 MSH6 NEIL1 NTAQ1 OGG1 PCNA POLB RAD1 RAD17 RAD9A RAD9B RHNO1 RPA1 RPA2 SDCBP SIRT6 TDG TOPBP1 YWHAQ	11 interacting genes: CAND1 CHUK CUL2 CUL3 HUS1 LNX1 PICK1 PLEKHG4 RCHY1 UBE2F UBE2M
Entrez ID		3364	84259
HPRD ID		04787	14520
Ensembl ID		ENSG00000136273	ENSG00000137692
Uniprot IDs		A4D2F2 O60921	B4DP84 Q9BTE7
PDB IDs		3A1J 3G65 3GGR 6J8Y 7Z6H 8GNN 8WU8	Not available
GO Terms Enriched among Interactors		DNA Repair Damaged DNA Binding DNA Damage Response DNA Metabolic Process Base-excision Repair Cellular Response To Stress DNA Damage Checkpoint Signaling Response To Radiation Signal Transduction In Response To DNA Damage DNA Recombination Nucleic Acid Metabolic Process Mismatch Repair Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Checkpoint Clamp Complex Mitotic Intra-S DNA Damage Checkpoint Signaling Double-strand Break Repair Negative Regulation Of Cell Cycle Phase Transition DNA Replication Checkpoint Signaling Site Of Double-strand Break Oxidized Purine DNA Binding Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process Protein Localization To Site Of Double-strand Break Response To Stress Mismatched DNA Binding Chromosome Organization Response To Ionizing Radiation Negative Regulation Of Cell Cycle Single Guanine Insertion Binding Dinucleotide Insertion Or Deletion Binding Base-excision Repair, Gap-filling Nucleoplasm Chromosome, Telomeric Region Guanine/thymine Mispair Binding Intracellular Signal Transduction Chromatin-protein Adaptor Activity Protein Localization To Chromosome Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Macromolecule Metabolic Process Recombinational Repair Regulation Of Cell Cycle Process Maintenance Of DNA Repeat Elements MutLalpha Complex Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Response To UV Nucleus Enzyme Binding Depyrimidination	Protein Modification By Small Protein Conjugation Cullin-RING Ubiquitin Ligase Complex Post-translational Protein Modification Ubiquitin-protein Transferase Activity NEDD8 Conjugating Enzyme Activity Protein Modification Process NEDD8 Transferase Activity Ubiquitin Ligase Complex Scaffold Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Cytosol Protein Metabolic Process Protein Neddylation Macromolecule Catabolic Process Macromolecule Metabolic Process Postsynapse Proteolysis Response To Acetate Protein Autoubiquitination Response To Cholecystokinin Meiotic DNA Integrity Checkpoint Signaling Trophectodermal Cellular Morphogenesis Cell Cycle G1/S Phase Transition Liver Morphogenesis G1/S Transition Of Mitotic Cell Cycle Ubiquitin Protein Ligase Activity SCF Complex Assembly Positive Regulation Of Type I Interferon Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process IkappaB Kinase Activity Regulation Protein Catabolic Process At Postsynapse Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex Response To Amino Acid POZ Domain Binding Membrane Curvature Sensor Activity NEDD8 Ligase Activity Regulation Of Type I Interferon Production Transferase Activity Checkpoint Clamp Complex Positive Regulation Of Post-translational Protein Modification Polar Microtubule Proteasomal Protein Catabolic Process Error-free Translesion Synthesis Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Mitotic Cell Cycle Phase Transition Nucleoplasm