HUS1 and HUS1B

Number of citations of the paper that reports this interaction (PMID 11944979)
7

Data Source:
HPRD (in vivo)

		HUS1	HUS1B
Gene Name		HUS1 checkpoint homolog (S. pombe)	HUS1 checkpoint homolog b (S. pombe)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Checkpoint Clamp Complex	Nucleolus Checkpoint Clamp Complex
	Molecular Function	Protein Binding
	Biological Process	DNA Damage Checkpoint Double-strand Break Repair Via Homologous Recombination Regulation Of Protein Phosphorylation DNA Replication DNA Repair Protein Phosphorylation Cellular Response To DNA Damage Stimulus Mitotic Cell Cycle Checkpoint Negative Regulation Of DNA Replication Response To UV Embryo Development Cellular Response To Ionizing Radiation	DNA Damage Checkpoint DNA Repair
Pathways		G2/M Checkpoints Activation of ATR in response to replication stress Cell Cycle Checkpoints
Drugs
Diseases
GWAS			Aging ( 22773346)
Protein-Protein Interactions		16 interactors: CD200 COPS5 DNAJC7 HDAC1 HUS1B MSH2 MSH3 MSH6 PCNA RAD1 RAD17 RAD9A RAD9B RPA1 RPA2 YWHAQ	4 interactors: HUS1 RAD1 RAD9A RAD9B
Entrez ID		3364	135458
HPRD ID		04787	13722
Ensembl ID		ENSG00000136273	ENSG00000188996
Uniprot IDs		A4D2F2 O60921	Q8NHY5
PDB IDs		3A1J 3G65 3GGR
Enriched GO Terms of Interacting Partners?		DNA Repair Cellular Response To DNA Damage Stimulus Mismatch Repair Cell Cycle DNA Damage Checkpoint Cell Cycle Process DNA Metabolic Process Cell Cycle Checkpoint Cellular Response To Stress Meiotic Mismatch Repair DNA Replication Positive Regulation Of Helicase Activity DNA Recombination Response To Stress Regulation Of DNA Recombination Nucleobase-containing Compound Metabolic Process Nucleotide-excision Repair, DNA Gap Filling Meiotic Cell Cycle Negative Regulation Of DNA Recombination Mitotic Cell Cycle Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Cell Cycle Negative Regulation Of DNA Metabolic Process Nuclear DNA Replication Telomere Maintenance Via Recombination Cellular Nitrogen Compound Metabolic Process Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Regulation Of Cell Cycle Telomere Maintenance Via Telomere Lengthening Somatic Recombination Of Immunoglobulin Gene Segments Nitrogen Compound Metabolic Process Somatic Diversification Of Immunoglobulins DNA Catabolic Process Maintenance Of DNA Repeat Elements Transcription-coupled Nucleotide-excision Repair Mitotic Cell Cycle Process Mitotic Cell Cycle Checkpoint DNA Recombinase Assembly Meiotic Nuclear Division Immunoglobulin Production Base-excision Repair Negative Regulation Of Mitotic Cell Cycle Cellular Response To Stimulus Telomere Maintenance Intra-S DNA Damage Checkpoint DNA Replication Checkpoint	DNA Damage Checkpoint Cell Cycle Checkpoint DNA Replication Cellular Response To Ionizing Radiation DNA Repair Cellular Response To Radiation Response To Ionizing Radiation Cellular Response To DNA Damage Stimulus Cell Cycle Process DNA Metabolic Process Cell Cycle DNA Catabolic Process, Exonucleolytic Cellular Response To Stress Response To Radiation Negative Regulation Of Cell Cycle DNA Catabolic Process Regulation Of Cell Cycle Mitotic Cell Cycle Checkpoint Meiotic Recombination Checkpoint Response To Abiotic Stimulus Response To Stress Negative Regulation Of Mitotic Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleic Acid Phosphodiester Bond Hydrolysis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Mitotic Cell Cycle Biosynthetic Process Intra-S DNA Damage Checkpoint DNA Replication Checkpoint Cellular Nitrogen Compound Metabolic Process Aromatic Compound Catabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Meiotic Nuclear Division Mitotic Cell Cycle Process Negative Regulation Of Meiotic Cell Cycle Mitotic Cell Cycle Cellular Response To Stimulus Substantia Nigra Development Regulation Of Meiosis Cellular Macromolecule Catabolic Process Negative Regulation Of DNA Replication Regulation Of Meiotic Cell Cycle Neural Nucleus Development Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Response To DNA Damage Stimulus Double-strand Break Repair Via Homologous Recombination
Tagcloud ?		abrogates atr bona checkpoint chk1 clamp claspin damaging extensively fide heterotetrameric impacting irradiation lac laco lacr lastly localizes onto orphan portion rad1 rad9 repeats repressor rhino tethering topbp1 uv
Tagcloud (Difference) ?		abrogates atr bona checkpoint chk1 clamp claspin damaging extensively fide heterotetrameric impacting irradiation lac laco lacr lastly localizes onto orphan portion rad1 rad9 repeats repressor rhino tethering topbp1 uv
Tagcloud (Intersection) ?