HUS1 and RAD9B

Number of citations of the paper that reports this interaction (PubMedID 14611806)
0

Data Source:
HPRD (in vivo)

		HUS1	RAD9B
Description		HUS1 checkpoint clamp component	RAD9 checkpoint clamp component B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Checkpoint Clamp Complex Site Of Double-strand Break	Nucleus Nucleoplasm Checkpoint Clamp Complex
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	DNA Damage Checkpoint Signaling Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Repair Nucleotide-excision Repair DNA Damage Response Response To Radiation Response To UV Embryo Development Ending In Birth Or Egg Hatching Mitotic Intra-S DNA Damage Checkpoint Signaling Mitotic DNA Replication Checkpoint Signaling Meiotic DNA Integrity Checkpoint Signaling Cellular Response To Ionizing Radiation	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling DNA Repair Mitotic Intra-S DNA Damage Checkpoint Signaling Cellular Response To Ionizing Radiation
Pathways		Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS		Gut microbiota alpha diversity (Shannon index) ( 33208821) Obstructive sleep apnea during REM sleep (apnea hypopnea index) ( 29077507)
Interacting Genes		28 interacting genes: C4orf46 CD200 DCUN1D5 DNAJC7 FEN1 GRIP1 HDAC1 HUS1B MSH2 MSH3 MSH6 NEIL1 NTAQ1 OGG1 PCNA POLB RAD1 RAD17 RAD9A RAD9B RHNO1 RPA1 RPA2 SDCBP SIRT6 TDG TOPBP1 YWHAQ	5 interacting genes: HUS1 HUS1B RAD1 RAD17 RAD9A
Entrez ID		3364	144715
HPRD ID		04787	12221
Ensembl ID		ENSG00000136273	ENSG00000151164
Uniprot IDs		A4D2F2 O60921	B4DX60 B4DYM6 J3KPN7 Q6WBX8
PDB IDs		3A1J 3G65 3GGR 6J8Y 7Z6H 8GNN 8WU8
Enriched GO Terms of Interacting Partners?		DNA Repair Damaged DNA Binding DNA Damage Response DNA Metabolic Process Base-excision Repair Cellular Response To Stress DNA Damage Checkpoint Signaling Response To Radiation Signal Transduction In Response To DNA Damage DNA Recombination Nucleic Acid Metabolic Process Mismatch Repair Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Checkpoint Clamp Complex Mitotic Intra-S DNA Damage Checkpoint Signaling Double-strand Break Repair Negative Regulation Of Cell Cycle Phase Transition DNA Replication Checkpoint Signaling Site Of Double-strand Break Oxidized Purine DNA Binding Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process Protein Localization To Site Of Double-strand Break Response To Stress Mismatched DNA Binding Chromosome Organization Response To Ionizing Radiation Negative Regulation Of Cell Cycle Single Guanine Insertion Binding Dinucleotide Insertion Or Deletion Binding Base-excision Repair, Gap-filling Nucleoplasm Chromosome, Telomeric Region Guanine/thymine Mispair Binding Intracellular Signal Transduction Chromatin-protein Adaptor Activity Protein Localization To Chromosome Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Macromolecule Metabolic Process Recombinational Repair Regulation Of Cell Cycle Process Maintenance Of DNA Repeat Elements MutLalpha Complex Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Response To UV Nucleus Enzyme Binding Depyrimidination	Checkpoint Clamp Complex DNA Replication Checkpoint Signaling Mitotic Intra-S DNA Damage Checkpoint Signaling DNA Damage Checkpoint Signaling Signal Transduction In Response To DNA Damage Negative Regulation Of Cell Cycle Phase Transition Meiotic Cell Cycle Checkpoint Signaling Negative Regulation Of Cell Cycle Process Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Mitotic DNA Replication Checkpoint Signaling Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition DNA Repair Meiotic DNA Integrity Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle DNA Metabolic Process Regulation Of Cell Cycle Process DNA Damage Response Mitotic G2/M Transition Checkpoint Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Cellular Response To Ionizing Radiation Regulation Of Cell Cycle Double-stranded DNA 3'-5' DNA Exonuclease Activity Site Of Double-strand Break Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Mitotic Cell Cycle Response To Ionizing Radiation Cellular Response To Stress Negative Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To Radiation Intracellular Signal Transduction Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Nucleotide-excision Repair Response To Radiation Response To Stress Rad17 RFC-like Complex Telomere Maintenance Telomere Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair Meiotic Recombination Checkpoint Signaling Signal Transduction Nucleolus Double-strand Break Repair Macromolecule Metabolic Process
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