PARP8

Description		poly(ADP-ribose) polymerase family member 8
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Membrane Endoplasmic Reticulum Tubular Network
	Molecular Function	NAD+ Poly-ADP-ribosyltransferase Activity Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Kinase Binding Protein Serine/threonine Kinase Activator Activity NAD+-protein-cysteine ADP-ribosyltransferase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	Endoplasmic Reticulum Unfolded Protein Response Protein Auto-ADP-ribosylation
Pathways		Nicotinate metabolism Maturation of nucleoprotein Maturation of nucleoprotein
Drugs
Diseases
GWAS		Callous-unemotional behaviour ( 23874384) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Childhood ear infection ( 27182965) General risk tolerance (MTAG) ( 30643258) HOMA-B (corrected for HOMA-IR) ( 30369944) Myopia (pathological) ( 22685421) Type 2 diabetes ( 30718926 32499647) Verbal declarative memory ( 25648963)
Interacting Genes		1 interacting genes: HTR6
Entrez ID		79668
HPRD ID		07960
Ensembl ID		ENSG00000151883
Uniprot IDs		B2RB27 E9PFI7 Q8N3A8
PDB IDs
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Activity Serotonin Receptor Activity Serotonin Receptor Signaling Pathway Histamine Receptor Activity Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Signaling Pathway Cerebral Cortex Cell Migration Forebrain Cell Migration Telencephalon Cell Migration G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of TOR Signaling Regulation Of TOR Signaling Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
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