SLC6A1 and HUNK

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		SLC6A1	HUNK
Description		solute carrier family 6 member 1	hormonally up-regulated Neu-associated kinase
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Axon Cell Projection Neuronal Cell Body Synapse Presynapse GABA-ergic Synapse	Cytoplasm
	Molecular Function	Amino Acid:sodium Symporter Activity Gamma-aminobutyric Acid:sodium:chloride Symporter Activity Protein Binding Gamma-aminobutyric Acid Transmembrane Transporter Activity Symporter Activity Sodium:chloride Symporter Activity Transmembrane Transporter Activity Metal Ion Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Amino Acid Transmembrane Transport Neurotransmitter Transport Amino Acid Transport Chemical Synaptic Transmission Memory Associative Learning Sodium Ion Transmembrane Transport Synapse Organization Gamma-aminobutyric Acid Reuptake Gamma-aminobutyric Acid Import Inorganic Anion Import Across Plasma Membrane Sodium Ion Import Across Plasma Membrane Neurotransmitter Reuptake Transport Across Blood-brain Barrier Chloride Transmembrane Transport	Signal Transduction Intracellular Signal Transduction
Pathways		SLC-mediated transport of neurotransmitters Reuptake of GABA
Drugs		Tiagabine Guvacine
Diseases
GWAS		Body fat percentage ( 31752434) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Loneliness (linear analysis) ( 27629369) Longitudinal alcohol consumption ( 26081443) Lung function ( 31902109) Refractive error ( 32231278) Response to Vitamin E supplementation ( 22437554)	Crohn's disease ( 32581322) Joint damage progression in ACPA-negative rheumatoid arthritis ( 26077402) LDL cholesterol levels in HIV infection ( 33109212) Response to antipsychotic treatment in schizophrenia (reasoning) ( 21107309) Type 2 diabetes ( 21490949) Vitiligo ( 19890347)
Interacting Genes		7 interacting genes: ARFGAP1 DRD2 HSF2BP HTR6 HUNK SNCA STX1A	92 interacting genes: AARS1 ABLIM1 ACTR8 AGAP3 AIP AKAP8L AKR1C3 ALAD ANXA7 APBA2 APPL2 ARMCX4 ASCL1 ASPA ATP5F1B BIN1 CAMK1 CCAR1 CLU COG2 COPA COPS4 COPS5 CTDSP1 CTR9 CXXC5 DIS3L DLAT DLST DNAJA1 DST EEF1A2 EFNA1 EIF4G1 EPRS1 GEN1 HEATR6 HEY1 IFT81 IFT88 KDM6A KIF3A LIMK1 LNX1 LRSAM1 LURAP1 MAGED1 MBD1 MCHR1 MGAT5B MOAP1 MORF4L2 MTMR10 MYCBP2 N4BP2L2 NAPA NEUROD2 OLR1 PICK1 PITHD1 PPP1R16B PTPRA PTPRD RAB5B RABEP1 SH2B1 SLC6A1 SMARCE1 SMYD2 SNRNP48 SNRNP70 SORBS1 SPARCL1 STMN1 STUB1 TAF1 TOMM6 TRIM68 TTC28 UBE2O USP8 VCPIP1 VPS35L VSNL1 ZBTB44 ZNF197 ZNF292 ZNF343 ZNF655 ZNF662 ZNF76 ZNF793
Entrez ID		6529	30811
HPRD ID		00664	09410
Ensembl ID		ENSG00000157103	ENSG00000142149
Uniprot IDs		A0A2R8Y4I3 B7Z3C5 P30531	P57058
PDB IDs		7SK2 7Y7V 7Y7W 7Y7Y 7Y7Z
Enriched GO Terms of Interacting Partners?		Regulation Of Catecholamine Secretion Dopamine Uptake Involved In Synaptic Transmission Regulation Of Amine Transport Regulation Of Dopamine Uptake Involved In Synaptic Transmission Neurotransmitter Transport Catecholamine Uptake Dopamine Uptake SNARE Complex Assembly Synaptic Transmission, Dopaminergic Synapse Synaptic Vesicle Membrane Behavioral Response To Cocaine Dopamine Transport Neurotransmitter Reuptake Positive Regulation Of Synaptic Transmission Regulation Of Neurotransmitter Uptake Positive Regulation Of Neurotransmitter Secretion Regulation Of Dopamine Secretion Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Vesicle-mediated Transport Monoamine Transport Neurotransmitter Uptake Dopamine Metabolic Process Response To Iron Ion Synaptic Vesicle Exocytosis Synaptic Vesicle Endocytosis Telencephalon Cell Migration Response To Cocaine Catecholamine Metabolic Process Presynaptic Endocytosis Forebrain Cell Migration Positive Regulation Of Secretion By Cell Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Chemical Synaptic Transmission Axon Terminus Regulation Of Endocytosis Positive Regulation Of Secretion Excitatory Postsynaptic Potential Trans-synaptic Signaling Biogenic Amine Metabolic Process Synaptic Signaling Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity SNARE Binding Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Myosin Head/neck Binding Receptor Internalization	Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Metal Ion Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Protein Catabolic Process Regulation Of Cellular Component Organization Negative Regulation Of Protein Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Fibril Formation Protein Modification By Small Protein Conjugation Regulation Of RNA Biosynthetic Process DeNEDDylase Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?