DEDD and MPZ

Data Source: HiPPIP (Novel)

		DEDD	MPZ
Name		death effector domain containing	myelin protein zero
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm	Plasma Membrane Membrane Myelin Sheath Synapse
	Molecular Function	DNA Binding Protein Binding	Structural Molecule Activity
	Biological Process	Developmental Process Involved In Reproduction Apoptotic Process Spermatogenesis Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Protein Catabolic Process Regulation Of Apoptotic Process Decidualization Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I	Chemical Synaptic Transmission Myelination Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell Aggregation
Pathways		None	EGR2 and SOX10-mediated initiation of Schwann cell myelination
Diseases		None	Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		No GWAS studies recorded	Hip circumference adjusted for BMI ( 28552196 ) Visceral adipose tissue adjusted for BMI ( 22589738 )
Novel Interactors		8 novel interactors: IRF9 MPZ NR1I3 PRRC2C SDHC SLC19A2 UAP1 VPS26A	3 novel interactors: DEDD HSPA6 RGS4
Interacting Genes		16 interacting genes: APLP2 APP BATF2 CASP10 CASP3 CASP8 CFLAR DEDD2 FADD GTF3C1 GTF3C3 HOXD4 KRT18 KRT8 SHMT1 SMAD3	3 interacting genes: PINX1 PMP22 PSMB3
Entrez ID		9191	4359
HPRD ID		06022	01159
Ensembl ID		ENSG00000158796	ENSG00000158887
Uniprot IDs		B1AQP5 O75618	A0A5F9ZI26 P25189
PDB IDs		Not available	3OAI 8IIA
GO Terms Enriched among Interactors		Ripoptosome CD95 Death-inducing Signaling Complex Death-inducing Signaling Complex Extrinsic Apoptotic Signaling Pathway Death Receptor Binding Apoptotic Signaling Pathway Death Effector Domain Binding Positive Regulation Of Neuron Apoptotic Process Apoptotic Process Programmed Cell Death Cell Death Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cysteine-type Endopeptidase Activity Positive Regulation Of Execution Phase Of Apoptosis Execution Phase Of Apoptosis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Necroptotic Process Regulation Of Programmed Necrotic Cell Death Regulation Of Neuron Apoptotic Process Response To Anesthetic Transcription Factor TFIIIC Complex 5S Class RRNA Transcription By RNA Polymerase III Cysteine-type Peptidase Activity Response To External Biotic Stimulus Epithelial Cell Apoptotic Process Positive Regulation Of Pyroptotic Inflammatory Response TRAIL-activated Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Response To Cobalt Ion Positive Regulation Of Interleukin-1 Beta Production Regulation Of Programmed Cell Death TRNA Transcription By RNA Polymerase III TRNA Transcription RNA Polymerase III General Transcription Initiation Factor Activity Scaffold Protein Binding Positive Regulation Of Interleukin-1 Production Cell Surface Receptor Signaling Pathway Cell Body Positive Regulation Of Macrophage Differentiation Hepatocyte Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction DNA Binding Transition Metal Ion Binding Platelet Alpha Granule Negative Regulation Of Necroptotic Process Regulation Of Interleukin-1 Beta Production Myeloid Cell Differentiation	None