DEDD and HOXD4

Number of citations: 41 (PubMedID 20211142)
Data Source: BioGRID (two hybrid)

		DEDD	HOXD4
Name		death effector domain containing	homeobox D4
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm	Chromatin Nucleus Nucleoplasm Cell Junction
	Molecular Function	DNA Binding Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Developmental Process Involved In Reproduction Apoptotic Process Spermatogenesis Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Protein Catabolic Process Regulation Of Apoptotic Process Decidualization Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I	Regulation Of DNA-templated Transcription Anterior/posterior Pattern Specification Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Embryonic Skeletal System Morphogenesis Stem Cell Differentiation
Pathways		None	Activation of anterior HOX genes in hindbrain development during early embryogenesis
GWAS		No GWAS studies recorded	Estimated glomerular filtration rate ( 31015462 ) Male-pattern baldness ( 28196072 ) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507 ) Pelvic organ prolapse (moderate/severe) ( 26545240 )
Novel Interactors		8 novel interactors: IRF9 MPZ NR1I3 PRRC2C SDHC SLC19A2 UAP1 VPS26A	None recorded
Interacting Genes		16 interacting genes: APLP2 APP BATF2 CASP10 CASP3 CASP8 CFLAR DEDD2 FADD GTF3C1 GTF3C3 HOXD4 KRT18 KRT8 SHMT1 SMAD3	21 interacting genes: ASB8 CNOT7 CREBBP DEDD EP300 ETV4 FANCL HIPK1 HNRNPAB HOXB13 MEIS1 PBX1 PBX4 RNPS1 RXRG SNAI1 TIGD4 XRCC6 ZBTB32 ZMYND11 ZSCAN18
Entrez ID		9191	3233
HPRD ID		06022	00864
Ensembl ID		ENSG00000158796	ENSG00000170166
Uniprot IDs		B1AQP5 O75618	P09016
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Ripoptosome CD95 Death-inducing Signaling Complex Death-inducing Signaling Complex Extrinsic Apoptotic Signaling Pathway Death Receptor Binding Apoptotic Signaling Pathway Death Effector Domain Binding Positive Regulation Of Neuron Apoptotic Process Apoptotic Process Programmed Cell Death Cell Death Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cysteine-type Endopeptidase Activity Positive Regulation Of Execution Phase Of Apoptosis Execution Phase Of Apoptosis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Necroptotic Process Regulation Of Programmed Necrotic Cell Death Regulation Of Neuron Apoptotic Process Response To Anesthetic Transcription Factor TFIIIC Complex 5S Class RRNA Transcription By RNA Polymerase III Cysteine-type Peptidase Activity Response To External Biotic Stimulus Epithelial Cell Apoptotic Process Positive Regulation Of Pyroptotic Inflammatory Response TRAIL-activated Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Response To Cobalt Ion Positive Regulation Of Interleukin-1 Beta Production Regulation Of Programmed Cell Death TRNA Transcription By RNA Polymerase III TRNA Transcription RNA Polymerase III General Transcription Initiation Factor Activity Scaffold Protein Binding Positive Regulation Of Interleukin-1 Production Cell Surface Receptor Signaling Pathway Cell Body Positive Regulation Of Macrophage Differentiation Hepatocyte Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction DNA Binding Transition Metal Ion Binding Platelet Alpha Granule Negative Regulation Of Necroptotic Process Regulation Of Interleukin-1 Beta Production Myeloid Cell Differentiation	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Chromatin DNA Binding Nucleus Negative Regulation Of RNA Metabolic Process Transcription Regulator Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Histone H3K27 Acetyltransferase Activity Positive Regulation Of RNA Metabolic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Eye Development Regulation Of Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleoplasm Animal Organ Morphogenesis Sensory Organ Development Hemopoiesis Negative Regulation Of Transcription By RNA Polymerase I Negative Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Damaged DNA Binding N-terminal Protein Amino Acid Acetylation Positive Regulation Of Biosynthetic Process Pattern Specification Process Peptidyl-lysine Acetylation Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Cellular Response To Heat Definitive Hemopoiesis