DEDD and HOXD4

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		DEDD	HOXD4
Gene Name		death effector domain containing	homeobox D4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm	Nucleus
	Molecular Function	DNA Binding Protein Binding	Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding
	Biological Process	Transcription, DNA-templated Spermatogenesis Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Protein Catabolic Process Regulation Of Apoptotic Process Decidualization Negative Regulation Of Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Multicellular Organismal Development
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: APLP2 APP BATF2 CASP10 CASP3 CASP8 CFLAR DEDD2 FADD GTF3C1 GTF3C3 HOXD4 KRT18 KRT8 SHMT1 SMAD3	19 interactors: ASB8 CNOT7 CREBBP DEDD EP300 ETV4 HIPK1 HNRNPAB HOXB13 MEIS1 PBX1 RNPS1 RXRG SNAI1 TIGD4 XRCC6 ZBTB32 ZMYND11 ZSCAN18
Entrez ID		9191	3233
HPRD ID		06022	00864
Ensembl ID		ENSG00000158796	ENSG00000170166
Uniprot IDs		B1AQP5 B4DKM1 O75618	P09016
PDB IDs
Enriched GO Terms of Interacting Partners?		Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Peptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Regulation Of Peptidase Activity Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Positive Regulation Of Proteolysis Regulation Of Proteolysis Hepatocyte Apoptotic Process Regulation Of Necroptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Protein Processing Regulation Of Necrotic Cell Death Viral Process TRAIL-activated Apoptotic Signaling Pathway Response To Tumor Necrosis Factor Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Cell Death Regulation Of Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling 5S Class RRNA Transcription From RNA Polymerase III Type 1 Promoter TRNA Transcription From RNA Polymerase III Promoter Positive Regulation Of Apoptotic Signaling Pathway Neuron Apoptotic Process TRNA Transcription Regulation Of Extrinsic Apoptotic Signaling Pathway Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Neuron Death Regulation Of I-kappaB Kinase/NF-kappaB Signaling Execution Phase Of Apoptosis Negative Regulation Of Programmed Cell Death Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Cell Death Positive Regulation Of Macrophage Differentiation Negative Regulation Of Necroptotic Process Positive Regulation Of Hydrolase Activity	Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Organ Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Tissue Development N-terminal Peptidyl-lysine Acetylation Multicellular Organismal Development Negative Regulation Of Biosynthetic Process Stem Cell Differentiation Anatomical Structure Development Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Organ Morphogenesis System Development Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Developmental Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Morphogenesis Positive Regulation Of Type I Interferon Production Stem Cell Development N-terminal Protein Amino Acid Acetylation Cell Differentiation
Tagcloud ?		actinobacteria cleaving detectable distant divergent duplex equivalent exoribonuclease founding homology hundreds hypothetical kingdom maintain mediating orthologs overhangs pathogen phylogenetically pool prevalent proteobacteria reveals ribonucleases rnase rnases rv2179c similarity strand	allowed canonical confers cos developmentally dnase element embryogenesis embryonal enhancer footprinting heterologous mimic morphogens nevertheless nt2 polyadenylation proper rars reproduces responsive retinoids sequential spatially specifying start temporally transactivated
Tagcloud (Difference) ?		actinobacteria cleaving detectable distant divergent duplex equivalent exoribonuclease founding homology hundreds hypothetical kingdom maintain mediating orthologs overhangs pathogen phylogenetically pool prevalent proteobacteria reveals ribonucleases rnase rnases rv2179c similarity strand	allowed canonical confers cos developmentally dnase element embryogenesis embryonal enhancer footprinting heterologous mimic morphogens nevertheless nt2 polyadenylation proper rars reproduces responsive retinoids sequential spatially specifying start temporally transactivated
Tagcloud (Intersection) ?