DEDD and SHMT1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		DEDD	SHMT1
Gene Name		death effector domain containing	serine hydroxymethyltransferase 1 (soluble)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Protein Binding	Glycine Hydroxymethyltransferase Activity L-allo-threonine Aldolase Activity Amino Acid Binding Pyridoxal Phosphate Binding Protein Homodimerization Activity
	Biological Process	Transcription, DNA-templated Spermatogenesis Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Protein Catabolic Process Regulation Of Apoptotic Process Decidualization Negative Regulation Of Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter	L-serine Catabolic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Purine Nucleobase Biosynthetic Process Glycine Biosynthetic Process From Serine Cellular Nitrogen Compound Metabolic Process Tetrahydrofolate Interconversion Small Molecule Metabolic Process Carnitine Biosynthetic Process Folic Acid Metabolic Process Protein Tetramerization Protein Homotetramerization
Pathways			Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Metabolism of amino acids and derivatives Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Carnitine synthesis Metabolism of folate and pterines Defective TCN2 causes hereditary megaloblastic anemia Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism
Drugs			Pyridoxal Phosphate Tetrahydrofolic acid Glycine Mimosine Triglu-5-Formyl-Tetrahydrofolate 5-Hydroxymethylene-6-Hydrofolic Acid N-Pyridoxyl-Glycine-5-Monophosphate
Diseases
GWAS
Protein-Protein Interactions		16 interactors: APLP2 APP BATF2 CASP10 CASP3 CASP8 CFLAR DEDD2 FADD GTF3C1 GTF3C3 HOXD4 KRT18 KRT8 SHMT1 SMAD3	7 interactors: CSNK2B DEDD DLEU1 MAPK9 PIM1 PRSS23 SULT1A3
Entrez ID		9191	6470
HPRD ID		06022	01643
Ensembl ID		ENSG00000158796	ENSG00000176974
Uniprot IDs		B1AQP5 B4DKM1 O75618	B4DPM9 P34896
PDB IDs			1BJ4
Enriched GO Terms of Interacting Partners?		Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Peptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Regulation Of Peptidase Activity Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Positive Regulation Of Proteolysis Regulation Of Proteolysis Hepatocyte Apoptotic Process Regulation Of Necroptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Protein Processing Regulation Of Necrotic Cell Death Viral Process TRAIL-activated Apoptotic Signaling Pathway Response To Tumor Necrosis Factor Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Cell Death Regulation Of Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling 5S Class RRNA Transcription From RNA Polymerase III Type 1 Promoter TRNA Transcription From RNA Polymerase III Promoter Positive Regulation Of Apoptotic Signaling Pathway Neuron Apoptotic Process TRNA Transcription Regulation Of Extrinsic Apoptotic Signaling Pathway Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Neuron Death Regulation Of I-kappaB Kinase/NF-kappaB Signaling Execution Phase Of Apoptosis Negative Regulation Of Programmed Cell Death Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Cell Death Positive Regulation Of Macrophage Differentiation Negative Regulation Of Necroptotic Process Positive Regulation Of Hydrolase Activity	Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Kinase Activity Negative Regulation Of Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter JUN Phosphorylation Apoptotic Process Regulation Of Catalytic Activity Programmed Cell Death Positive Regulation Of Prostaglandin Biosynthetic Process Cell Death Death Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Activin Receptor Signaling Pathway Adiponectin-activated Signaling Pathway Phosphate-containing Compound Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Endothelial Tube Morphogenesis Protein Phosphorylation Apoptotic Signaling Pathway Protein Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Prostaglandin Secretion Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Regulation Of Apoptotic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Positive Regulation Of Catalytic Activity Regulation Of Transcription From RNA Polymerase I Promoter Regulation Of Cell Death Positive Regulation Of Icosanoid Secretion Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Metabolic Process Sulfation Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Kinase Activity Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Kinase Activity Positive Regulation Of Fatty Acid Transport Flavonoid Metabolic Process Decidualization Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Tagcloud ?		actinobacteria cleaving detectable distant divergent duplex equivalent exoribonuclease founding homology hundreds hypothetical kingdom maintain mediating orthologs overhangs pathogen phylogenetically pool prevalent proteobacteria reveals ribonucleases rnase rnases rv2179c similarity strand	aa aas african american ancestry asian associations carbon circle comparisons copyright correcting ea eas eleven european folate metabolizing modest mtr mtrr participated polygenetic polymorphisms reserved rights slc19a1 snps tyms
Tagcloud (Difference) ?		actinobacteria cleaving detectable distant divergent duplex equivalent exoribonuclease founding homology hundreds hypothetical kingdom maintain mediating orthologs overhangs pathogen phylogenetically pool prevalent proteobacteria reveals ribonucleases rnase rnases rv2179c similarity strand	aa aas african american ancestry asian associations carbon circle comparisons copyright correcting ea eas eleven european folate metabolizing modest mtr mtrr participated polygenetic polymorphisms reserved rights slc19a1 snps tyms
Tagcloud (Intersection) ?