DEDD and PRRC2C

		DEDD	PRRC2C
Description		death effector domain containing	proline rich coiled-coil 2C
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm	Cytoplasm Cytosol Cytoplasmic Stress Granule Membrane
	Molecular Function	DNA Binding Protein Binding	RNA Binding Protein Binding
	Biological Process	Developmental Process Involved In Reproduction Apoptotic Process Spermatogenesis Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Protein Catabolic Process Regulation Of Apoptotic Process Decidualization Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I	Hematopoietic Progenitor Cell Differentiation Stress Granule Assembly
Pathways
Drugs
Diseases
GWAS			Adult body size ( 32376654) Alzheimer's disease (cognitive decline) ( 23535033) Cognitive decline rate in late mild cognitive impairment ( 26252872) Creatinine levels ( 29403010) Daytime nap ( 33568662) Estimated glomerular filtration rate ( 31015462 31152163) Glomerular filtration rate ( 29403010) HDL cholesterol levels ( 32203549) Microalbuminuria ( 31511532) Platelet distribution width ( 32888494) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31511532 31630189)
Interacting Genes		16 interacting genes: APLP2 APP BATF2 CASP10 CASP3 CASP8 CFLAR DEDD2 FADD GTF3C1 GTF3C3 HOXD4 KRT18 KRT8 SHMT1 SMAD3	4 interacting genes: CEBPA HINFP RNF10 SRPK2
Entrez ID		9191	23215
HPRD ID		06022	16539
Ensembl ID		ENSG00000158796	ENSG00000117523
Uniprot IDs		B1AQP5 O75618	E7EPN9 Q9Y520
PDB IDs
Enriched GO Terms of Interacting Partners?		Ripoptosome CD95 Death-inducing Signaling Complex Death-inducing Signaling Complex Extrinsic Apoptotic Signaling Pathway Death Receptor Binding Apoptotic Signaling Pathway Death Effector Domain Binding Positive Regulation Of Neuron Apoptotic Process Apoptotic Process Programmed Cell Death Cell Death Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cysteine-type Endopeptidase Activity Positive Regulation Of Execution Phase Of Apoptosis Execution Phase Of Apoptosis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Necroptotic Process Regulation Of Programmed Necrotic Cell Death Regulation Of Neuron Apoptotic Process Response To Anesthetic Transcription Factor TFIIIC Complex 5S Class RRNA Transcription By RNA Polymerase III Cysteine-type Peptidase Activity Response To External Biotic Stimulus Epithelial Cell Apoptotic Process Positive Regulation Of Pyroptotic Inflammatory Response TRAIL-activated Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Response To Cobalt Ion Positive Regulation Of Interleukin-1 Beta Production Regulation Of Programmed Cell Death TRNA Transcription By RNA Polymerase III TRNA Transcription RNA Polymerase III General Transcription Initiation Factor Activity Scaffold Protein Binding Positive Regulation Of Interleukin-1 Production Cell Surface Receptor Signaling Pathway Cell Body Positive Regulation Of Macrophage Differentiation Hepatocyte Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction DNA Binding Transition Metal Ion Binding Platelet Alpha Granule Negative Regulation Of Necroptotic Process Regulation Of Interleukin-1 Beta Production Myeloid Cell Differentiation	Nucleolus Transcription Cis-regulatory Region Binding Regulation Of RNA Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Response To Vitamin B2 C/EBP Complex Positive Regulation Of Biosynthetic Process Response To Lithium Ion Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Transcription By RNA Polymerase I Urea Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Macromolecule Biosynthetic Process Signal Transduction Cellular Response To Lithium Ion CHOP-C/EBP Complex HMG Box Domain Binding Response To Phenylpropanoid Regulation Of Primary Metabolic Process Positive Regulation Of Gene Expression RNA Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Cell Cycle Nitrogen Cycle Metabolic Process White Fat Cell Differentiation Regulation Of Macromolecule Metabolic Process Urea Cycle Interleukin-6-mediated Signaling Pathway Regulation Of RNA Biosynthetic Process DNA Binding Regulation Of Gene Expression Negative Regulation Of Cell Development White Fat Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Negative Regulation Of RNA Biosynthetic Process STAT Family Protein Binding Positive Regulation Of Transcription By RNA Polymerase II Osteoblast Development Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Fat Cell Proliferation R-loop Processing Nuclear Speck Organization Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I
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