DNAJB1 and DNM2

		DNAJB1	DNM2
Description		DnaJ heat shock protein family (Hsp40) member B1	dynamin 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Postsynaptic Density Neuronal Cell Body Dendritic Spine Sperm Head Extracellular Exosome Postsynapse Glutamatergic Synapse	Golgi Membrane Phagocytic Cup Uropod Podosome Cytoplasm Endosome Golgi Apparatus Centrosome Centriole Cytosol Cytoskeleton Microtubule Plasma Membrane Clathrin-coated Pit Focal Adhesion Endomembrane System Postsynaptic Density Membrane Clathrin-coated Vesicle Growth Cone Midbody Endocytic Vesicle Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Cell Projection Neuron Projection Synapse Postsynaptic Membrane Recycling Endosome Extracellular Exosome Anchoring Junction Presynapse
	Molecular Function	ATPase Activator Activity Transcription Corepressor Activity Protein Binding Hsp70 Protein Binding Protein Folding Chaperone Cadherin Binding Unfolded Protein Binding Protein-folding Chaperone Binding ATPase Binding Transcription Regulator Inhibitor Activity	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Phosphatidylinositol-4,5-bisphosphate Binding Microtubule Binding Hydrolase Activity SH3 Domain Binding Enzyme Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Folding Response To Unfolded Protein Forebrain Development Cellular Response To Heat Negative Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat Positive Regulation Of Protein Folding	G2/M Transition Of Mitotic Cell Cycle Regulation Of DNA-templated Transcription Post-Golgi Vesicle-mediated Transport Endocytosis Receptor-mediated Endocytosis Phagocytosis Autophagy Centrosome Cycle Signal Transduction Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Axon Extension Receptor Internalization Transferrin Transport Positive Regulation Of Apoptotic Process Stress Fiber Assembly Positive Regulation Of DNA-templated Transcription Synaptic Vesicle Transport Neuron Projection Morphogenesis Protein Polymerization Membrane Organization Actin Filament Bundle Organization Membrane Tubulation Vesicle Scission Negative Regulation Of Membrane Tubulation
Pathways		Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase HSF1-dependent transactivation MAPK6/MAPK4 signaling	Toll Like Receptor 4 (TLR4) Cascade Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions NOSTRIN mediated eNOS trafficking MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Recycling pathway of L1 Clathrin-mediated endocytosis NGF-stimulated transcription Degradation of CDH1
Drugs
Diseases			Centronuclear myopathy Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Adventurousness ( 30643258) General risk tolerance (MTAG) ( 30643258)	Bipolar disorder ( 31043756) Height ( 25429064) Hip circumference adjusted for BMI ( 34021172) Hyperlipidemia (time to event) ( 32589924) LDL cholesterol ( 21347282) Waist-hip index ( 34021172)
Interacting Genes		33 interacting genes: A2M AKT1 ANK2 APP BDKRB1 BRCA1 BRMS1 CEBPA CENPE CYP2C8 DNAJC3 DYRK3 ECSIT FANCA FANCC GLB1 GSK3A HSF1 HSPA1A MAST1 NQO1 NRAS PEA15 PLEKHO1 PPDPF PSEN2 PTGES3 SOD1 SPP1 STUB1 TERF1 TTLL12 ZFP36	74 interacting genes: AMPH AOC1 AP2A1 APP APPL1 ARX ATF7IP ATXN3 BAG3 BIN1 CCDC90B CCR5 CCT7 CDK1 CEBPA CTTN DDX39B DYNC1I1 DYNLL1 EIF3L EPS15 FLAD1 FNBP1L FXR1 FXR2 GDF9 GOLGA2 GRAP2 GRB2 HCK HMGB1 ITSN1 KDR MAN1B1 MANEA MPHOSPH6 NTAQ1 PALS2 PCNT PDE6G PFN1 PPIB PRKAA2 PSTPIP1 PTK2 PYGM QARS1 RHOU RNF8 RPS2 RWDD2B SDCBP SEC23A SH3GL2 SH3GLB1 SH3RF1 SHANK1 SHANK2 SHANK3 SMARCA2 SNAPIN SNX9 SPRY2 SRC TIAM2 TRAF4 TRIP10 TYK2 UBASH3A VAV1 WBP4 XIAP ZBTB16 ZFAND6
Entrez ID		3337	1785
HPRD ID		05198	03852
Ensembl ID		ENSG00000132002	ENSG00000079805
Uniprot IDs		P25685 Q6FHS4	P50570 Q8N1K8
PDB IDs		1HDJ 2QLD 3AGX 3AGY 3AGZ 4WB7 6BYR 6WJF 6WJG 6Z5N 7NDX 8FE2 8FE5 8FEC	2YS1
Enriched GO Terms of Interacting Partners?		Enzyme Binding Regulation Of Programmed Cell Death Regulation Of Growth Regulation Of Apoptotic Process Intracellular Signal Transduction Response To Temperature Stimulus Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Heat Cellular Response To Metal Ion Protein-folding Chaperone Binding Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Response To Lipid Regulation Of Developmental Growth Positive Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Response To Steroid Hormone Intracellular Signaling Cassette Misfolded Protein Binding Positive Regulation Of Macromolecule Metabolic Process Cytoplasm Negative Regulation Of Programmed Cell Death Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of Apoptotic Process Heat Shock Protein Binding Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Positive Regulation Of Catabolic Process Response To Peptide Regulation Of Cell Growth Protein-containing Complex Positive Regulation Of Gene Expression Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Cell Growth Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Response To Hormone Cellular Response To Topologically Incorrect Protein Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response Regulation Of Cell Development Signal Transduction Regulation Of Cell Cycle Response To Stress Regulation Of Cellular Component Organization Regulation Of Immune System Process Negative Regulation Of Apoptotic Process	Cytosol Endocytosis Cytoplasm Import Into Cell Cadherin Binding Positive Regulation Of Cellular Component Organization Positive Regulation Of Catabolic Process Vesicle-mediated Transport Identical Protein Binding Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Metabolic Process Regulation Of Endocytosis Regulation Of Biological Quality Vesicle-mediated Transport In Synapse Regulation Of Cellular Component Organization Regulation Of Cellular Component Size Synaptic Receptor Adaptor Activity Regulation Of Signaling Dendritic Spine Positive Regulation Of Organelle Organization Clathrin-coated Pit Synaptic Vesicle Endocytosis Cellular Localization Establishment Of Localization In Cell Proline-rich Region Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Communication Organelle Organization Presynaptic Endocytosis Regulation Of MAPK Cascade Phosphotyrosine Residue Binding Positive Regulation Of Protein Polymerization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Protein-containing Complex Assembly Synapse Regulation Of Apoptotic Process Regulation Of Long-term Neuronal Synaptic Plasticity Intracellular Transport Postsynaptic Endocytic Zone Regulation Of Vesicle-mediated Transport Positive Regulation Of Developmental Process Regulation Of Developmental Process Regulation Of Intracellular Signal Transduction Positive Regulation Of JNK Cascade Positive Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Glutamatergic Synapse Ionotropic Glutamate Receptor Binding
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