HSPA1A and GPR37

Number of citations of the paper that reports this interaction (PMID 12150907)
82

Data Source:
BioGRID (pull down)

		HSPA1A	GPR37
Gene Name		heat shock 70kDa protein 1A	G protein-coupled receptor 37 (endothelin receptor type B-like)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Centriole Cytosol Focal Adhesion COP9 Signalosome Inclusion Body Aggresome Nuclear Speck Ribonucleoprotein Complex Vesicle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Blood Microparticle	Ubiquitin Ligase Complex Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	Virus Receptor Activity G-protein Coupled Receptor Binding Double-stranded RNA Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding ATPase Activity, Coupled Protein Binding Involved In Protein Folding Poly(A) RNA Binding Protein N-terminus Binding Unfolded Protein Binding	G-protein Coupled Receptor Activity Protein Binding G-protein Coupled Peptide Receptor Activity Hsp70 Protein Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Peptide Binding
	Biological Process	MRNA Catabolic Process Response To Unfolded Protein Negative Regulation Of Cell Proliferation Response To Virus Gene Expression Regulation Of Cell Death Negative Regulation Of Cell Growth Negative Regulation Of Protein Ubiquitination Cellular Response To Oxidative Stress Cellular Response To Heat Protein Refolding Negative Regulation Of Apoptotic Process Positive Regulation Of Erythrocyte Differentiation Protein Stabilization Negative Regulation Of Cell Death Cellular Heat Acclimation Negative Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Locomotion Involved In Locomotory Behavior Dopamine Biosynthetic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Dopamine Metabolic Process Negative Regulation Of Hydrogen Peroxide-induced Cell Death
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements Viral RNP Complexes in the Host Cell Nucleus Attenuation phase Regulation of HSF1-mediated heat shock response Cellular response to heat stress AUF1 (hnRNP D0) destabilizes mRNA Influenza Infection Influenza Life Cycle HSF1-dependent transactivation Export of Viral Ribonucleoproteins from Nucleus	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Reading and spelling ( 23738518)
Protein-Protein Interactions		79 interactors: AIFM1 APAF1 APEX1 APOB ATXN1 BAG1 BAG2 BAG3 BAG4 BCL2 BRSK1 CACNA1E CDK9 CFAP52 DAPP1 DNAJA2 DNAJA3 DNAJB1 DNAJB11 DNAJC3 DNAJC7 DYX1C1 EGFR EIF2AK2 FANCC FOS GPR37 GRIN1 GRIN2D HCFC1 HIVEP1 HMGA1 HSBP1 HSF1 HSP90AA1 HSPA8 HSPBP1 IKBKG KRT18 KRT7 MAP3K5 MAPRE1 METTL21A MOS MSR1 NQO1 NR3C1 PEX5 PLG POT1 PPP1R15A PRKCA PTGES3 PTMA RAP1A RAPGEF2 RHOA SAE1 SLC5A1 SNCA SNCB SNRK SOX9 ST13 STIP1 STUB1 TCERG1 TGM2 TOMM70A TP53 TRIAP1 TRIM24 TRIM38 TSSK6 TTC1 YWHAB YWHAG YWHAQ YWHAZ	8 interactors: ADRB2 GLP1R GRIP1 HSPA1A PARK2 SDCBP STUB1 SYVN1
Entrez ID		3303	2861
HPRD ID		00774	03992
Ensembl ID		ENSG00000204389
Uniprot IDs		A8K5I0 B3KTT5 P08107	O15354
PDB IDs		1HJO 1S3X 1XQS 2E88 2E8A 2LMG 3A8Y 3ATU 3ATV 3AY9 3D2E 3D2F 3JXU 3LOF 4J8F
Enriched GO Terms of Interacting Partners?		Protein Refolding Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Death Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Protein Folding Chaperone Cofactor-dependent Protein Refolding Response To Organic Substance Cellular Response To Stimulus Response To Stress Signaling Positive Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Response To Stress Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Cell Communication Positive Regulation Of Cell Death Response To Stimulus Positive Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Signaling Regulation Of Catalytic Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Metabolic Process Regulation Of Cellular Process Regulation Of Signal Transduction Regulation Of Cellular Component Organization Response To Abiotic Stimulus Positive Regulation Of Phosphorylation Negative Regulation Of Cell Death Positive Regulation Of Signal Transduction Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Intrinsic Apoptotic Signaling Pathway Cellular Protein Metabolic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Regulation Of Cellular Response To Heat Regulation Of Phosphorus Metabolic Process Negative Regulation Of Biosynthetic Process Apoptotic Signaling Pathway Apoptotic Process	Response To Unfolded Protein Regulation Of Protein Ubiquitination Positive Regulation Of Cellular Metabolic Process Cellular Response To Unfolded Protein Regulation Of Signaling Cellular Response To Topologically Incorrect Protein Positive Regulation Of Metabolic Process Positive Regulation Of Protein Ubiquitination Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Response To Endoplasmic Reticulum Stress Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Cellular Response To Stimulus Activation Of Adenylate Cyclase Activity Regulation Of Phosphorus Metabolic Process Protein K63-linked Ubiquitination Regulation Of Signal Transduction Positive Regulation Of Adenylate Cyclase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Signaling Pathway Proteasomal Protein Catabolic Process Regulation Of Binding Protein Autoubiquitination Regulation Of Metabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Lyase Activity Positive Regulation Of Protein Modification Process Negative Regulation Of Protein Binding Regulation Of Adenylate Cyclase Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of CAMP Biosynthetic Process Response To Stress Response To Stimulus Regulation Of Cyclase Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Signaling Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cell Communication Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Mitochondrial Fusion Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Protein Stabilization Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity
Tagcloud ?		chaperone complement defective dnaja1 dnajb1 enlarged experimentally heat hspa6 hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1	biosynthetic cd47 cycs dataset dj e2f6 eif2s1 eif2s2 encyclopedia extra fmr1 fxr2 logical mapt nrf1 paelr park2 park6 park7 parkin pen2 perturbation pink1 psenen retrieved seq stringent tomm34 unrecognized
Tagcloud (Difference) ?		chaperone complement defective dnaja1 dnajb1 enlarged experimentally heat hspa6 hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1	biosynthetic cd47 cycs dataset dj e2f6 eif2s1 eif2s2 encyclopedia extra fmr1 fxr2 logical mapt nrf1 paelr park2 park6 park7 parkin pen2 perturbation pink1 psenen retrieved seq stringent tomm34 unrecognized
Tagcloud (Intersection) ?