HSPA1A and BCL2

Number of citations of the paper that reports this interaction (PubMedID 10354271)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		HSPA1A	BCL2
Description		heat shock protein family A (Hsp70) member 1A	BCL2 apoptosis regulator
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Centrosome Centriole Cytosol Cytoskeleton Plasma Membrane Focal Adhesion COP9 Signalosome Inclusion Body Aggresome Nuclear Speck Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen Ribonucleoprotein Complex	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Nuclear Membrane Mitochondrial Membrane Protein-containing Complex Myelin Sheath Pore Complex Bcl-2 Family Protein Complex BAD-BCL-2 Complex
	Molecular Function	Nucleotide Binding Virus Receptor Activity G Protein-coupled Receptor Binding Transcription Corepressor Activity RNA Binding Signaling Receptor Binding Protein Binding ATP Binding ATP Hydrolysis Activity Enzyme Binding Heat Shock Protein Binding Denatured Protein Binding Ubiquitin Protein Ligase Binding Death Receptor Agonist Activity Histone Deacetylase Binding Protein Folding Chaperone Cadherin Binding Receptor Ligand Activity Unfolded Protein Binding Misfolded Protein Binding C3HC4-type RING Finger Domain Binding Disordered Domain Specific Binding Transcription Regulator Inhibitor Activity ATP-dependent Protein Disaggregase Activity ATP-dependent Protein Folding Chaperone	Protease Binding Protein Binding Channel Activity Channel Inhibitor Activity Protein Phosphatase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity BH3 Domain Binding Protein Phosphatase 2A Binding Molecular Adaptor Activity DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MRNA Catabolic Process Protein Folding Response To Unfolded Protein Lysosomal Transport Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Cell Growth Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Regulation Of Protein Ubiquitination Negative Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Interleukin-8 Production Positive Regulation Of RNA Splicing Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To Unfolded Protein Protein Refolding Negative Regulation Of Apoptotic Process Positive Regulation Of Erythrocyte Differentiation ATP Metabolic Process Symbiont Entry Into Host Cell Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Chaperone-mediated Protein Complex Assembly Cellular Heat Acclimation Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Microtubule Nucleation Negative Regulation Of Inclusion Body Assembly Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitotic Spindle Assembly Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Cell Morphogenesis Ossification Ovarian Follicle Development Metanephros Development Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Behavioral Fear Response Leukocyte Homeostasis B Cell Homeostasis B Cell Apoptotic Process Kidney Development Release Of Cytochrome C From Mitochondria Regulation Of Cell-matrix Adhesion Lymphocyte Homeostasis Lymphoid Progenitor Cell Differentiation B Cell Lineage Commitment T Cell Lineage Commitment Immune System Development Negative Regulation Of B Cell Apoptotic Process Response To Ischemia Renal System Process Melanin Metabolic Process Regulation Of Nitrogen Utilization Intracellular Calcium Ion Homeostasis Autophagy Apoptotic Process Humoral Immune Response DNA Damage Response Response To Oxidative Stress Actin Filament Organization Axonogenesis Female Pregnancy Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Apoptotic Mitochondrial Changes Response To Radiation Response To Xenobiotic Stimulus Response To Toxic Substance Post-embryonic Development Animal Organ Morphogenesis Response To Iron Ion Response To UV-B Response To Gamma Radiation Regulation Of Gene Expression Regulation Of Autophagy Negative Regulation Of Autophagy Negative Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Glycoprotein Biosynthetic Process Mesenchymal Cell Development Positive Regulation Of Neuron Maturation Smooth Muscle Cell Migration Positive Regulation Of Smooth Muscle Cell Migration Cell Migration Cochlear Nucleus Development Gland Morphogenesis Hemopoiesis B Cell Differentiation T Cell Differentiation Negative Regulation Of Ossification Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Melanocyte Differentiation Negative Regulation Of Cell Migration Positive Regulation Of B Cell Proliferation Hair Follicle Morphogenesis Axon Regeneration Regulation Of Protein Stability Endoplasmic Reticulum Calcium Ion Homeostasis Glomerulus Development Negative Regulation Of Cellular PH Reduction Regulation Of Protein Localization Myeloid Cell Apoptotic Process Negative Regulation Of Myeloid Cell Apoptotic Process T Cell Differentiation In Thymus Osteoblast Proliferation Negative Regulation Of Osteoblast Proliferation Response To Cytokine Response To Nicotine Organ Growth Regulation Of Growth Positive Regulation Of Multicellular Organism Growth B Cell Proliferation Cellular Response To Glucose Starvation Response To Hydrogen Peroxide Neuron Maturation Regulation Of Apoptotic Process T Cell Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death CD8-positive, Alpha-beta T Cell Lineage Commitment Pigmentation Negative Regulation Of Neuron Apoptotic Process Ear Development Regulation Of Viral Genome Replication Positive Regulation Of Melanocyte Differentiation Negative Regulation Of Mitotic Cell Cycle Retinal Cell Programmed Cell Death Negative Regulation Of Retinal Cell Programmed Cell Death Regulation Of Mitochondrial Membrane Permeability Focal Adhesion Assembly Developmental Pigmentation Regulation Of Developmental Pigmentation Positive Regulation Of Developmental Pigmentation Spleen Development Thymus Development Response To Steroid Hormone Digestive Tract Morphogenesis Developmental Growth Oocyte Development Skeletal Muscle Fiber Development Positive Regulation Of Skeletal Muscle Fiber Development Pigment Granule Organization Stem Cell Development Homeostasis Of Number Of Cells Within A Tissue B Cell Receptor Signaling Pathway Response To Glucocorticoid Neuron Apoptotic Process Defense Response To Virus Establishment Of Localization In Cell Regulation Of Cell Cycle Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Mitochondrial Depolarization Regulation Of Calcium Ion Transport Hematopoietic Stem Cell Differentiation Calcium Ion Transport Into Cytosol Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Lymphocyte Apoptotic Process Negative Regulation Of Lymphocyte Apoptotic Process T Cell Apoptotic Process Negative Regulation Of T Cell Apoptotic Process Cellular Response To Hypoxia Reactive Oxygen Species Metabolic Process Dendritic Cell Apoptotic Process Motor Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell-cell Adhesion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Intracellular Signal Transduction Epithelial Cell Apoptotic Process Negative Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Dendritic Cell Apoptotic Process Negative Regulation Of Motor Neuron Apoptotic Process Negative Regulation Of Anoikis Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Viral RNP Complexes in the Host Cell Nucleus Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase HSF1-dependent transactivation AUF1 (hnRNP D0) binds and destabilizes mRNA Neutrophil degranulation PKR-mediated signaling Mitochondrial unfolded protein response (UPRmt) Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase HSF1-dependent transactivation Neutrophil degranulation PKR-mediated signaling Mitochondrial unfolded protein response (UPRmt)	Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-4 and Interleukin-13 signaling The NLRP1 inflammasome Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling NFE2L2 regulating tumorigenic genes Regulation of MITF-M-dependent genes involved in apoptosis
Drugs			Ibuprofen Paclitaxel Docetaxel Rasagiline AN-9 Paclitaxel docosahexaenoic acid Apoptone Eribulin Dexibuprofen Venetoclax Obatoclax Navitoclax Terpinen-4-ol Oleandrin
Diseases			Cervical cancer Kaposi's sarcoma Chronic lymphocytic leukemia (CLL) Gastric cancer Nasopharyngeal cancer Choriocarcinoma Small cell lung cancer
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Inflammatory bowel disease ( 28067908) Schizophrenia ( 30285260) Systemic lupus erythematosus ( 32771030) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	A body shape index ( 34021172) Adult body size ( 32376654) Alanine aminotransferase levels ( 34315874 33547301) Albumin-globulin ratio ( 29403010) Aspartate aminotransferase levels ( 34315874 33547301) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Body mass index ( 28892062 25673413) Body mass index and fasting insulin (pairwise) ( 33619380) Body mass index and triglycerides (pairwise) ( 33619380) Body mass index and type 2 diabetes (pairwise) ( 33619380) Cardiac Troponin-T levels ( 23247143) Chronic lymphocytic leukemia ( 23770605 28165464 26956414) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Excessive hairiness ( 29895819) Fasting insulin ( 34059833) Follicular lymphoma ( 25279986) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip index ( 34021172) Lymphocyte count ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Male-pattern baldness ( 28196072) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Modified Stumvoll Insulin Sensitivity Index (BMI interaction) ( 27416945) Modified Stumvoll Insulin Sensitivity Index (model adjusted for BMI) ( 27416945) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 27863252 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269 28346444) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Prostate cancer ( 29892016) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) Red blood cell count ( 32888494 27863252) Response to adalimumab in hidradenitis suppurativa (abscess and inflammatory nodule count increase) ( 31465739) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494) Serum omega-6 polyunsaturated fatty acid concentration in metabolic syndrome ( 31991592) Serum total protein levels ( 29403010) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653 30578418) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Two-hour glucose ( 34059833) Type 2 diabetes ( 28869590) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412) White blood cell count ( 32888494) White blood cell count (basophil) ( 27863252)
Interacting Genes		95 interacting genes: ACE2 AIFM1 APAF1 APEX1 APOB ATXN1 BAG1 BAG2 BAG3 BAG4 BCL2 BRSK1 CACNA1E CDK9 CFAP52 DAPP1 DNAAF4 DNAJA2 DNAJA3 DNAJB1 DNAJB11 DNAJB4 DNAJC3 EGFR EIF2AK2 EIF4ENIF1 ERBB2 ERBB3 FANCC FILNC1 FNDC3B FOS FTCD GPR37 GRIN1 GRIN2D HAP1 HCFC1 HEMGN HIVEP1 HMGA1 HSBP1 HSF1 HSPA8 HSPBP1 IKBKG INS KRT18 KRT7 MAP3K5 MAPRE1 METTL21A MOS MSR1 NQO1 NR3C1 OGT PEX5 PGR PLG POT1 PPP1R15A PRKCA PSMC5 PTGES3 PTMA PTPRF RAP1A RAPGEF2 RHOA SAE1 SLC13A1 SLC5A1 SNCB SNRK SOX9 ST13 STIP1 STUB1 SUMO2 TCERG1 TGM2 TOMM70 TP53 TRIAP1 TRIM24 TRIM38 TSSK6 TTC1 UBE2D3 XIAP YWHAB YWHAG YWHAQ YWHAZ	89 interacting genes: ATP2A2 BAD BAG1 BAG3 BAG4 BAG6 BAK1 BAX BBC3 BCAP31 BCL2L1 BCL2L10 BCL2L11 BCL2L12 BCL2L14 BCLAF1 BECN1 BFAR BID BIK BLK BMF BNIP1 BNIP2 BNIP3 BNIP3L BNIPL CAPN2 CASP3 CASP8 CDK1 CDK2 CPT1A CYCS FKBP8 HRAS HRK HSPA1A ITM2B ITPR1 KRAS MAPK1 MAPK11 MAPK14 MAPK3 MAPK8 MEX3D MOAP1 MYC NCL NLRP1 NMT2 NR4A1 NRAS PARP1 PIN1 PKMYT1 PMAIP1 PML PPARA PPID PPP1CA PPP2CA PPP2R5A PPP3CA PPP3CC PRKACA PRKCA PSEN1 PXN RAD9A RAF1 RNF183 RRAS RTN4 SEPTIN4 SF1 SIVA1 SMN1 SOD1 SPHK2 SPNS1 SQSTM1 TMBIM6 TOMM20 TP53 TP53AIP1 TP53BP2 XIAP
Entrez ID		3303	596
HPRD ID		00774	01045
Ensembl ID		ENSG00000204389	ENSG00000171791
Uniprot IDs		A8K5I0 B3KTT5 P0DMV8 P0DMV9	A0A7I2V3S7 P10415
PDB IDs		1HJO 1S3X 1XQS 2E88 2E8A 2LMG 3A8Y 3ATU 3ATV 3AY9 3D2E 3D2F 3JXU 3LOF 3Q49 4IO8 4J8F 4PO2 4WV5 4WV7 5AQW 5AQX 5AQY 5AQZ 5AR0 5BN8 5BN9 5BPL 5BPM 5BPN 5GJJ 5MKR 5MKS 5XI9 5XIR 6FDT 6FHK 6G3R 6G3S 6JPV 6K39 6ZYI 7F4X 7F4Z 7F50 7FGM 7GY4 7GY5 7GY6 7GY7 7GY8 7GY9 7GYA 7GYB 7GYC 7GYD 7GYE 7GYF 7GYG 7GYH 7GYI 7GYJ 7GYK 7GYL 7GYM 7GYN 7GYO 7GYP 7GYQ 7GYR 7GYS 7GYT 7GYU 7GYV 7GYW 7GYX 7KW7 7Q4R	1G5M 1GJH 1YSW 2O21 2O22 2O2F 2W3L 2XA0 4AQ3 4IEH 4LVT 4LXD 4MAN 5AGW 5AGX 5FCG 5JSN 5VAU 5VAX 5VAY 6GL8 6IWB 6O0K 6O0L 6O0M 6O0O 6O0P 7LHB 7Y90 7YA5 8FY1 8FY2 8HLL 8HLM 8HLN 8HOG 8HOH 8HOI 8HTR 8HTS 8IQL 8U27 8VWX 8VWZ 8VXM 8VXN
Enriched GO Terms of Interacting Partners?		Regulation Of Programmed Cell Death Protein-folding Chaperone Binding Protein Folding Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Cytosol Positive Regulation Of Macromolecule Metabolic Process Protein Folding Chaperone Complex Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Apoptotic Process Cytoplasm Intracellular Signal Transduction Heat Shock Protein Binding Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Protein-containing Complex Intracellular Signaling Cassette Ubiquitin Protein Ligase Binding Response To Stress Regulation Of Protein Metabolic Process Hsp70 Protein Binding Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Adenyl-nucleotide Exchange Factor Activity Apoptotic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Stability Response To Heat Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Programmed Cell Death Negative Regulation Of RNA Metabolic Process Cell Death Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cellular Response To Oxygen-containing Compound Regulation Of Signal Transduction Negative Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Response To Temperature Stimulus Neuron Apoptotic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction	Apoptotic Process Programmed Cell Death Cell Death Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Intracellular Signal Transduction Apoptotic Signaling Pathway Cellular Response To Stress Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Release Of Cytochrome C From Mitochondria Response To Stress Regulation Of Release Of Cytochrome C From Mitochondria Mitochondrion Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Regulation Of Intracellular Signal Transduction Mitochondrial Outer Membrane Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Cellular Component Organization Negative Regulation Of Apoptotic Process Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Signal Transduction Positive Regulation Of Signaling Apoptotic Mitochondrial Changes Positive Regulation Of Cell Communication Positive Regulation Of Organelle Organization Regulation Of Mitochondrial Membrane Permeability Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Intracellular Signal Transduction Mitochondrial Membrane Organization Regulation Of Cellular Component Organization Mitochondrion Organization Regulation Of Membrane Permeability Release Of Cytochrome C From Mitochondria DNA Damage Response Regulation Of Organelle Organization Positive Regulation Of Signal Transduction Response To Decreased Oxygen Levels Regulation Of Cellular Response To Stress Extrinsic Apoptotic Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress Response To Oxygen Levels Cytosol
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