HSPA1A and BRSK1

Number of citations of the paper that reports this interaction (PMID 16306228)
29

Data Source:
HPRD (in vitro, in vivo)

		HSPA1A	BRSK1
Gene Name		heat shock 70kDa protein 1A	BR serine/threonine kinase 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Centriole Cytosol Focal Adhesion COP9 Signalosome Inclusion Body Aggresome Nuclear Speck Ribonucleoprotein Complex Vesicle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Blood Microparticle	Nucleus Nucleoplasm Cytoplasm Centrosome Synaptic Vesicle Cell Junction
	Molecular Function	Virus Receptor Activity G-protein Coupled Receptor Binding Double-stranded RNA Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding ATPase Activity, Coupled Protein Binding Involved In Protein Folding Poly(A) RNA Binding Protein N-terminus Binding Unfolded Protein Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity ATP Binding Protein Kinase Binding Gamma-tubulin Binding Tau-protein Kinase Activity
	Biological Process	MRNA Catabolic Process Response To Unfolded Protein Negative Regulation Of Cell Proliferation Response To Virus Gene Expression Regulation Of Cell Death Negative Regulation Of Cell Growth Negative Regulation Of Protein Ubiquitination Cellular Response To Oxidative Stress Cellular Response To Heat Protein Refolding Negative Regulation Of Apoptotic Process Positive Regulation Of Erythrocyte Differentiation Protein Stabilization Negative Regulation Of Cell Death Cellular Heat Acclimation Negative Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Protein Phosphorylation Cellular Response To DNA Damage Stimulus Neurotransmitter Secretion Axonogenesis Response To UV Response To Ionizing Radiation Establishment Of Cell Polarity Neuron Differentiation G2 DNA Damage Checkpoint Centrosome Duplication
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements Viral RNP Complexes in the Host Cell Nucleus Attenuation phase Regulation of HSF1-mediated heat shock response Cellular response to heat stress AUF1 (hnRNP D0) destabilizes mRNA Influenza Infection Influenza Life Cycle HSF1-dependent transactivation Export of Viral Ribonucleoproteins from Nucleus
Drugs
Diseases
GWAS			Menarche and menopause (age at onset) ( 19448621) Menopause (age at onset) ( 19448619)
Protein-Protein Interactions		79 interactors: AIFM1 APAF1 APEX1 APOB ATXN1 BAG1 BAG2 BAG3 BAG4 BCL2 BRSK1 CACNA1E CDK9 CFAP52 DAPP1 DNAJA2 DNAJA3 DNAJB1 DNAJB11 DNAJC3 DNAJC7 DYX1C1 EGFR EIF2AK2 FANCC FOS GPR37 GRIN1 GRIN2D HCFC1 HIVEP1 HMGA1 HSBP1 HSF1 HSP90AA1 HSPA8 HSPBP1 IKBKG KRT18 KRT7 MAP3K5 MAPRE1 METTL21A MOS MSR1 NQO1 NR3C1 PEX5 PLG POT1 PPP1R15A PRKCA PTGES3 PTMA RAP1A RAPGEF2 RHOA SAE1 SLC5A1 SNCA SNCB SNRK SOX9 ST13 STIP1 STUB1 TCERG1 TGM2 TOMM70A TP53 TRIAP1 TRIM24 TRIM38 TSSK6 TTC1 YWHAB YWHAG YWHAQ YWHAZ	8 interactors: BRCA1 CDC25B CDC25C HSD17B7 HSPA1A PAK1 UBC WEE1
Entrez ID		3303	84446
HPRD ID		00774	12533
Ensembl ID		ENSG00000204389	ENSG00000160469
Uniprot IDs		A8K5I0 B3KTT5 P08107	Q8TDC3
PDB IDs		1HJO 1S3X 1XQS 2E88 2E8A 2LMG 3A8Y 3ATU 3ATV 3AY9 3D2E 3D2F 3JXU 3LOF 4J8F
Enriched GO Terms of Interacting Partners?		Protein Refolding Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Death Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Protein Folding Chaperone Cofactor-dependent Protein Refolding Response To Organic Substance Cellular Response To Stimulus Response To Stress Signaling Positive Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Response To Stress Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Cell Communication Positive Regulation Of Cell Death Response To Stimulus Positive Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Signaling Regulation Of Catalytic Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Metabolic Process Regulation Of Cellular Process Regulation Of Signal Transduction Regulation Of Cellular Component Organization Response To Abiotic Stimulus Positive Regulation Of Phosphorylation Negative Regulation Of Cell Death Positive Regulation Of Signal Transduction Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Intrinsic Apoptotic Signaling Pathway Cellular Protein Metabolic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Regulation Of Cellular Response To Heat Regulation Of Phosphorus Metabolic Process Negative Regulation Of Biosynthetic Process Apoptotic Signaling Pathway Apoptotic Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Cell Cycle Process Regulation Of Cell Cycle Process Regulation Of Protein Metabolic Process Cell Cycle Regulation Of Protein Ubiquitination Mitotic Cell Cycle Process Positive Regulation Of Cell Cycle Process Cellular Protein Metabolic Process Regulation Of Protein Kinase Activity Mitotic Cell Cycle Regulation Of Kinase Activity Positive Regulation Of Cell Cycle Mitotic Nuclear Division Positive Regulation Of Protein Modification Process Cellular Protein Modification Process Protein Metabolic Process Regulation Of Protein Phosphorylation Response To Abiotic Stimulus Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Cellular Protein Metabolic Process Cell Division DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation JNK Cascade Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Signal Transduction In Response To DNA Damage Positive Regulation Of Kinase Activity Regulation Of Cell Cycle Arrest Negative Regulation Of Protein Ubiquitination Regulation Of Phosphorylation T Cell Receptor Signaling Pathway Viral Process Signal Transduction By P53 Class Mediator Positive Regulation Of Transferase Activity Cellular Heat Acclimation Positive Regulation Of Histone H3-K9 Acetylation Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Positive Regulation Of Protein Ubiquitination
Tagcloud ?		chaperone complement defective dnaja1 dnajb1 enlarged experimentally heat hspa6 hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1	aicar ampk ampkbeta blunted brsk2 c433s caax cys433 farnesylated farnesylation fertile imidazolecarboxamide knockin lkb1 lkb1c433s lkb1s431a mark4 mimetic myristoylation nuak nuak1 phenformin prenylated raises riboside s431a ser431 sik3 snf1
Tagcloud (Difference) ?		chaperone complement defective dnaja1 dnajb1 enlarged experimentally heat hspa6 hsps initiated interpreted keratinocytes nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1	aicar ampk ampkbeta blunted brsk2 c433s caax cys433 farnesylated farnesylation fertile imidazolecarboxamide lkb1 lkb1c433s lkb1s431a mark4 mimetic myristoylation nuak nuak1 phenformin prenylated raises riboside s431a ser431 sik3 snf1
Tagcloud (Intersection) ?		knockin