GTF2A2 and TAF4

Number of citations of the paper that reports this interaction (PubMedID 11564872)
46

Data Source:
HPRD (in vitro)

		GTF2A2	TAF4
Description		general transcription factor IIA subunit 2	TATA-box binding protein associated factor 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIA Complex Cytosol	Chromatin Male Germ Cell Nucleus Nucleus Nucleoplasm Transcription Factor TFIID Complex Cytosol Protein-containing Complex Transcription Factor TFTC Complex MLL1 Complex
	Molecular Function	RNA Polymerase II General Transcription Initiation Factor Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity TBP-class Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Core Promoter Sequence-specific DNA Binding DNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity Aryl Hydrocarbon Receptor Binding Protein Heterodimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II	Ovarian Follicle Development Regulation Of DNA Repair DNA-templated Transcription DNA-templated Transcription Initiation Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter MRNA Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways		HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance Estrogen-dependent gene expression	HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance
Drugs
Diseases
GWAS		Macular thickness ( 30535121)	Body mass index ( 28892062) Fasting glucose ( 33381925) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Red blood cell count ( 32888494) Response to fenofibrate (LDL cholesterol levels) ( 27002377)
Interacting Genes		9 interacting genes: GTF2A1 GTF2A1L GTF2E1 HSF1 PTPN11 TAF4 TBP TBPL1 TRIM7	22 interacting genes: AHR ATF7 CBX3 CBX5 CREM GTF2A1 GTF2A2 H3-4 HTT JUN SP1 TAF1 TAF10 TAF11 TAF12 TAF2 TAF5 TAF6 TAF7 TAF8 TAF9 TCF12
Entrez ID		2958	6874
HPRD ID		02747	11797
Ensembl ID		ENSG00000140307	ENSG00000130699
Uniprot IDs		B2R506 P52657	O00268
PDB IDs		1NVP 5FUR 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 5M4S 6MZM 6O9L 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7EGD 7EGI 7EGJ 7ENA 7ENC 7LBM 7NVR 7NVS 7NVT 7NVU 7NVY 7NVZ 7NW0 7ZWC 7ZWD 7ZX7 7ZX8 7ZXE 8BVW 8BYQ 8BZ1 8GXQ 8GXS 8S51 8S52 8S5N 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS	1H3O 2P6V 6MZC 6MZD 6MZL 6MZM 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7EGD 7EGE 7EGF 7EGG 7EGI 7EGJ 7ENA 7ENC 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS
Enriched GO Terms of Interacting Partners?		Transcription Factor TFIIA Complex DNA-templated Transcription Initiation RNA Polymerase II General Transcription Initiation Factor Activity Transcription Initiation At RNA Polymerase II Promoter Transcription Factor TFIID Complex Transcription By RNA Polymerase II Male Germ Cell Nucleus DNA-templated Transcription RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Metabolic Process Nucleobase-containing Compound Biosynthetic Process RNA Polymerase II Preinitiation Complex Assembly Transcription Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II RNA Polymerase II General Transcription Initiation Factor Binding Pronucleus Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Aryl Hydrocarbon Receptor Binding Nucleic Acid Metabolic Process Regulation Of DNA-templated Transcription Initiation Macromolecule Metabolic Process Macromolecule Biosynthetic Process Core Promoter Sequence-specific DNA Binding Nucleobase-containing Compound Metabolic Process Protein-DNA Complex Assembly RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleus DNA Binding MRNA Transcription By RNA Polymerase II Protein-containing Complex Euchromatin MRNA Transcription Cellular Response To Nitroglycerin Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Positive Regulation Of Macromolecule Biosynthetic Process Protein Heterodimerization Activity Developmental Process Involved In Reproduction Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Transcription Factor TFIIE Complex Response To Nitroglycerin Sequence-specific Single Stranded DNA Binding Cellular Response To Diamide Intestinal Epithelial Cell Migration General Transcription Initiation Factor Activity Positive Regulation Of RNA Metabolic Process Translation Elongation Factor Binding	Transcription Factor TFIID Complex RNA Polymerase II General Transcription Initiation Factor Activity Positive Regulation Of DNA-templated Transcription Initiation RNA Polymerase II Preinitiation Complex Assembly Regulation Of DNA-templated Transcription Initiation Transcription Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter DNA-templated Transcription Initiation MRNA Transcription By RNA Polymerase II Protein-DNA Complex Assembly MRNA Transcription Positive Regulation Of Transcription By RNA Polymerase II Transcription Factor TFTC Complex Transcription By RNA Polymerase II Protein Heterodimerization Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process TBP-class Protein Binding Nucleoplasm Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Nucleobase-containing Compound Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Nucleus Protein-containing Complex Assembly Regulation Of Gene Expression Transcription Cis-regulatory Region Binding Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Regulation Of Primary Metabolic Process Protein-containing Complex Organization Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of DNA Repair Regulation Of Macromolecule Metabolic Process SAGA Complex RNA Metabolic Process RNA Polymerase II General Transcription Initiation Factor Binding MLL1 Complex
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