GTF2A2 and TRIM7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GTF2A2	TRIM7
Description		general transcription factor IIA subunit 2	tripartite motif containing 7
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIA Complex Cytosol	Nucleus Cytoplasm Golgi Apparatus
	Molecular Function	RNA Polymerase II General Transcription Initiation Factor Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity TBP-class Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II	Protein Ubiquitination Innate Immune Response Defense Response To Virus Antiviral Innate Immune Response
Pathways		HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Macular thickness ( 30535121)
Interacting Genes		9 interacting genes: GTF2A1 GTF2A1L GTF2E1 HSF1 PTPN11 TAF4 TBP TBPL1 TRIM7	30 interacting genes: AQP1 ATG7 BCAM CDK13 CFL2 CRYGC CTNNAL1 DES GTF2A2 GYG1 IRAK4 MAD2L2 NAA35 NABP1 OTUD6A RAB2A RIN1 RNASE1 RNF187 RSPH14 SIAH1 SRC TP53I13 TRMT10A UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2N UBE2W
Entrez ID		2958	81786
HPRD ID		02747	11648
Ensembl ID		ENSG00000140307	ENSG00000146054
Uniprot IDs		B2R506 P52657	Q9C029
PDB IDs		1NVP 5FUR 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 5M4S 6MZM 6O9L 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7EGD 7EGI 7EGJ 7ENA 7ENC 7LBM 7NVR 7NVS 7NVT 7NVU 7NVY 7NVZ 7NW0 7ZWC 7ZWD 7ZX7 7ZX8 7ZXE 8BVW 8BYQ 8BZ1 8GXQ 8GXS 8S51 8S52 8S5N 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS	6UMA 6UMB 7OVX 7OW2 7W0Q 7W0S 7W0T 7X6Y 7X6Z 7X70 7Y3A 7Y3B 7Y3C 8A5L 8A5M 8A8X 8R5B 8R5C 8R5D 9HIN
Enriched GO Terms of Interacting Partners?		Transcription Factor TFIIA Complex DNA-templated Transcription Initiation RNA Polymerase II General Transcription Initiation Factor Activity Transcription Initiation At RNA Polymerase II Promoter Transcription Factor TFIID Complex Transcription By RNA Polymerase II Male Germ Cell Nucleus DNA-templated Transcription RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Metabolic Process Nucleobase-containing Compound Biosynthetic Process RNA Polymerase II Preinitiation Complex Assembly Transcription Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II RNA Polymerase II General Transcription Initiation Factor Binding Pronucleus Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Aryl Hydrocarbon Receptor Binding Nucleic Acid Metabolic Process Regulation Of DNA-templated Transcription Initiation Macromolecule Metabolic Process Macromolecule Biosynthetic Process Core Promoter Sequence-specific DNA Binding Nucleobase-containing Compound Metabolic Process Protein-DNA Complex Assembly RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleus DNA Binding MRNA Transcription By RNA Polymerase II Protein-containing Complex Euchromatin MRNA Transcription Cellular Response To Nitroglycerin Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Positive Regulation Of Macromolecule Biosynthetic Process Protein Heterodimerization Activity Developmental Process Involved In Reproduction Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Transcription Factor TFIIE Complex Response To Nitroglycerin Sequence-specific Single Stranded DNA Binding Cellular Response To Diamide Intestinal Epithelial Cell Migration General Transcription Initiation Factor Activity Positive Regulation Of RNA Metabolic Process Translation Elongation Factor Binding	Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Post-translational Protein Modification Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Protein K48-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Transferase Activity Protein Monoubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process TORC1 Signaling Negative Regulation Of TORC1 Signaling Protein Ubiquitination TOR Signaling Proteasomal Protein Catabolic Process Negative Regulation Of TOR Signaling Proteolysis Regulation Of TORC1 Signaling Macromolecule Catabolic Process Protein Modification Process Cytosol Protein Catabolic Process Cellular Response To Nutrient Levels Regulation Of TOR Signaling Catabolic Process Protein Autoubiquitination Nucleus Ubiquitin Protein Ligase Activity Extracellular Exosome ATP Binding Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Polyubiquitination Nucleotide Binding Intracellular Signal Transduction Protein Binding Endolysosomal Toll-like Receptor Signaling Pathway Macromolecule Metabolic Process Ephrin Receptor Binding Regulation Of Protein Polyubiquitination Ficolin-1-rich Granule Lumen Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Nitric Oxide Transmembrane Transporter Activity Metanephric Proximal Convoluted Tubule Segment 2 Development Supramolecular Fiber Organization Defense Response To Virus Response To Nutrient Levels Postreplication Repair
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