SPSB1

Gene Name		splA/ryanodine receptor domain and SOCS box containing 1
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Gene Ontology Annotations	Cellular Component	Cytoplasm
	Molecular Function	Protein Binding
	Biological Process	Protein Ubiquitination Intracellular Signal Transduction
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Dental caries ( 23064961) Immune response to anthrax vaccine ( 22658931) Response to tocilizumab in rheumatoid arthritis ( 22491018)
Protein-protein Interactions		10 interactors: ATM DDX4 KDM1A MET NOS2 PAWR PRMT1 PRMT6 RASA1 SUV39H1
Entrez ID		80176
HPRD ID		18106
Ensembl ID		ENSG00000171621
Uniprot IDs		Q96BD6
PDB IDs		2JK9 3F2O
Enriched GO Terms of Interacting Partners?		Histone Modification Peptidyl-amino Acid Modification Chromatin Modification Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Organelle Organization RNA Metabolic Process Chromatin Organization Peptidyl-arginine N-methylation Histone H4-R3 Methylation Histone Methylation Negative Regulation Of B Cell Proliferation Histone Arginine Methylation Peptidyl-arginine Methylation Regulation Of Megakaryocyte Differentiation Chromosome Organization Cell Development Protein Methylation Regulation Of RNA Metabolic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Nucleobase-containing Compound Metabolic Process Cellular Protein Modification Process Negative Regulation Of Cellular Metabolic Process Regulation Of Hematopoietic Progenitor Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Immune System Process Regulation Of Gene Expression Cell Differentiation Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of B Cell Activation Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Response To Hypoxia Regulation Of Cell Death Regulation Of Metabolic Process Developmental Process Nitrogen Compound Metabolic Process Protein Metabolic Process Regulation Of B Cell Proliferation Regulation Of Organelle Organization Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Immune System Process Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Regulation Of Primitive Erythrocyte Differentiation Negative Regulation Of Leukocyte Proliferation Response To Stimulus Cellular Protein Metabolic Process
Tagcloud ?		attributable contributes define downregulation emphasizes engineered genetically identifies implicating mammary mediator met neu overexpressing pharmacologic positively potentiation preexisting principal principally promoting protect recurrence relapse spontaneously sufficient turn upregulated