SPSB1 and PAWR

Number of citations of the paper that reports this interaction (PMID 20561531)
9

Data Source:
BioGRID (unspecified method)

		SPSB1	PAWR
Gene Name		splA/ryanodine receptor domain and SOCS box containing 1	PRKC, apoptosis, WT1, regulator
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleus Cytoplasm Actin Filament Plasma Membrane Actin Cytoskeleton
	Molecular Function	Protein Binding	Transcription Corepressor Activity Actin Binding Protein Binding Enzyme Binding Leucine Zipper Domain Binding
	Biological Process	Protein Ubiquitination Intracellular Signal Transduction	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Apoptotic Process Negative Regulation Of Cell Proliferation Negative Regulation Of B Cell Proliferation Interleukin-2 Biosynthetic Process Negative Regulation Of T Cell Proliferation Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Apoptotic Process Negative Regulation Of T Cell Receptor Signaling Pathway Actin Filament Bundle Assembly Apoptotic Signaling Pathway
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Dental caries ( 23064961) Immune response to anthrax vaccine ( 22658931) Response to tocilizumab in rheumatoid arthritis ( 22491018)	Attention deficit hyperactivity disorder and conduct disorder ( 18951430)
Protein-Protein Interactions		10 interactors: ATM DDX4 KDM1A MET NOS2 PAWR PRMT1 PRMT6 RASA1 SUV39H1	17 interactors: AATF ATP5C1 DAPK3 DRD2 FBXO45 HSPA5 PML PRKCZ RRAS2 SLC5A7 SPSB1 SPSB2 SPSB4 SQSTM1 TFPT THAP1 WT1
Entrez ID		80176	5074
HPRD ID		18106	09051
Ensembl ID		ENSG00000171621
Uniprot IDs		Q96BD6	Q96IZ0
PDB IDs		2JK9 3F2O	2JK9
Enriched GO Terms of Interacting Partners?		Histone Modification Peptidyl-amino Acid Modification Chromatin Modification Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Organelle Organization RNA Metabolic Process Chromatin Organization Peptidyl-arginine N-methylation Histone H4-R3 Methylation Histone Methylation Negative Regulation Of B Cell Proliferation Histone Arginine Methylation Peptidyl-arginine Methylation Regulation Of Megakaryocyte Differentiation Chromosome Organization Cell Development Protein Methylation Regulation Of RNA Metabolic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Nucleobase-containing Compound Metabolic Process Cellular Protein Modification Process Negative Regulation Of Cellular Metabolic Process Regulation Of Hematopoietic Progenitor Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Immune System Process Regulation Of Gene Expression Cell Differentiation Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of B Cell Activation Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Response To Hypoxia Regulation Of Cell Death Regulation Of Metabolic Process Developmental Process Nitrogen Compound Metabolic Process Protein Metabolic Process Regulation Of B Cell Proliferation Regulation Of Organelle Organization Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Immune System Process Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Regulation Of Primitive Erythrocyte Differentiation Negative Regulation Of Leukocyte Proliferation Response To Stimulus Cellular Protein Metabolic Process	Regulation Of Cell Death Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Cell Death Apoptotic Signaling Pathway Cellular Response To Stimulus Signaling Cell Communication Signal Transduction Negative Regulation Of Translation Apoptotic Process Programmed Cell Death Regulation Of Protein Metabolic Process Cell Death Death Response To Stimulus Cellular Metabolic Process Response To Organic Substance Cellular Response To Organic Substance Regulation Of Mitotic Cell Cycle Response To Stress Regulation Of Cellular Protein Metabolic Process Establishment Of Localization In Cell Long-term Memory Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Cell Cycle Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Response To Interleukin-4 Cellular Response To Stress Negative Regulation Of Cell Death Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Response To Interleukin-4 Protein Ubiquitination Cellular Response To Growth Factor Stimulus Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Cell Migration Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Morphogenesis Of A Branching Structure Response To Growth Factor Proteasomal Protein Catabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Translation In Response To Oxidative Stress
Tagcloud ?		attributable contributes define downregulation emphasizes engineered genetically identifies implicating mammary mediator met neu overexpressing pharmacologic positively potentiation preexisting principal principally promoting protect recurrence relapse spontaneously sufficient turn upregulated	aggravating airway airways asthma asthmatic ats cawr coexisting expiratory fev1 forced fvc gastroesophageal gerd hz impulse ios ninety oscillometry pef plethysmography presences reflux representative sec severity tawr verified vital
Tagcloud (Difference) ?		attributable contributes define downregulation emphasizes engineered genetically identifies implicating mammary mediator met neu overexpressing pharmacologic positively potentiation preexisting principal principally promoting protect recurrence relapse spontaneously sufficient turn upregulated	aggravating airway airways asthma asthmatic ats cawr coexisting expiratory fev1 forced fvc gastroesophageal gerd hz impulse ios ninety oscillometry pef plethysmography presences reflux representative sec severity tawr verified vital
Tagcloud (Intersection) ?