SPSB1 and PAWR

Number of citations of the paper that reports this interaction (PubMedID 20561531)
36

Data Source:
BioGRID (unspecified method)

		SPSB1	PAWR
Description		splA/ryanodine receptor domain and SOCS box containing 1	pro-apoptotic WT1 regulator
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GO Annotations	Cellular Component	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex	Chromatin Nucleus Cytoplasm Cytosol Actin Filament Plasma Membrane Actin Cytoskeleton
	Molecular Function	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Transcription Corepressor Activity Actin Binding Protein Binding Enzyme Binding Leucine Zipper Domain Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of B Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Fibroblast Proliferation Negative Regulation Of T Cell Receptor Signaling Pathway Actin Filament Bundle Assembly Apoptotic Signaling Pathway Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Cellular Senescence
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		A body shape index ( 34021172) Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Cognitive function ( 28093568) Dental caries ( 23064961) Eosinophil count ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494) Height ( 31562340 28552196) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Immune response to anthrax vaccine ( 22658931) Metabolite levels ( 23823483) Neutrophil percentage of granulocytes ( 27863252) Pulse pressure ( 30578418 27841878) Response to tocilizumab in rheumatoid arthritis ( 22491018) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30578418 27841878) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Brain morphology (MOSTest) ( 32665545)
Interacting Genes		14 interacting genes: ADPRH ATM DDX4 KDM1A MET NOS2 PAWR PRMT1 PRMT6 RASA1 SUV39H1 TRIM55 TRIM63 VWA5A	14 interacting genes: AATF ATP5F1C DAPK3 DRD2 HSPA5 PML PRKCZ RRAS2 SLC5A7 SPSB1 SQSTM1 TFPT THAP1 WT1
Entrez ID		80176	5074
HPRD ID		18106	09051
Ensembl ID		ENSG00000171621	ENSG00000177425
Uniprot IDs		Q96BD6	Q96IZ0
PDB IDs		2JK9 3F2O	2JK9
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Metabolic Process Chromatin Remodeling Protein-arginine Omega-N Monomethyltransferase Activity Histone Methyltransferase Activity Histone H4R3 Methyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Protein-arginine N-methyltransferase Activity Chromatin Organization Regulation Of DNA Repair Regulation Of Double-strand Break Repair Via Homologous Recombination DNA Repair Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of B Cell Proliferation Negative Regulation Of Macromolecule Biosynthetic Process Protein Modification Process Negative Regulation Of Biosynthetic Process Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Gene Expression Transferase Activity Regulation Of DNA Recombination Histone H3 Methyltransferase Activity Negative Regulation Of Catabolic Process Cellular Response To Gamma Radiation Regulation Of Double-strand Break Repair Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Enzyme Binding Negative Regulation Of Macromolecule Metabolic Process Methyltransferase Activity Negative Regulation Of B Cell Activation Determination Of Adult Lifespan Regulation Of Cell Communication Regulation Of Signaling Regulation Of Megakaryocyte Differentiation Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Meiosis I Regulation Of Intracellular Signal Transduction Negative Regulation Of Double-strand Break Repair Methylation Regulation Of DNA Metabolic Process Negative Regulation Of DNA Repair Negative Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Nucleobase-containing Compound Metabolic Process Peroxisomal Matrix Male Meiotic Nuclear Division Negative Regulation Of DNA Recombination Regulation Of Cellular Response To Stress Response To Starvation GATOR1 Complex Binding Hepatocyte Growth Factor Receptor Activity	PML Body Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Leucine Zipper Domain Binding Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Regulation Of DNA-templated Transcription Regulation Of Cellular Component Organization Intracellular Signal Transduction Regulation Of RNA Biosynthetic Process Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Synaptic Transmission Morphogenesis Of A Branching Structure Ionotropic Glutamate Receptor Binding Response To Interleukin-4 Cellular Response To Interleukin-4 Regulation Of RNA Metabolic Process Temperature Homeostasis Negative Regulation Of Translation Regulation Of Synaptic Plasticity Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Programmed Cell Death Maintenance Of Protein Localization In Organelle Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Myosin II Filament Organization Regulation Of Protein Metabolic Process Regulation Of Cellular Response To Stress Regulation Of Protein Folding In Endoplasmic Reticulum Negative Regulation Of Translation In Response To Oxidative Stress Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Choline:sodium Symporter Activity Regulation Of Macromolecule Biosynthetic Process Maintenance Of Protein Location In Cell Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Circadian Regulation Of Gene Expression G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Positive Regulation Of DNA-templated Transcription Protein Catabolic Process Cerebellum Structural Organization Maintenance Of Protein Location Maintenance Of Location In Cell Positive Regulation Of Telomere Maintenance Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Visceral Serous Pericardium Development
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