ERAS and PIK3CD

Number of citations: 0 (PubMedID 12774123)
Data Source: HPRD (in vivo)

		ERAS	PIK3CD
Name		ES cell expressed Ras	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding	Nucleotide Binding Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Transferase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity
	Biological Process	Signal Transduction Ras Protein Signal Transduction	Natural Killer Cell Differentiation Positive Regulation Of Cytokine Production Positive Regulation Of Endothelial Cell Proliferation Adaptive Immune Response Immune System Process Leukocyte Mediated Immunity Mast Cell Chemotaxis Respiratory Burst Involved In Defense Response Protein Phosphorylation Lipid Metabolic Process Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression T Cell Chemotaxis Cell Migration Regulation Of Anatomical Structure Morphogenesis Natural Killer Cell Activation Cell Differentiation B Cell Differentiation T Cell Differentiation Positive Regulation Of Cell Migration Neutrophil Chemotaxis T Cell Costimulation Positive Regulation Of Neutrophil Apoptotic Process Natural Killer Cell Chemotaxis B Cell Chemotaxis Phosphatidylinositol-3-phosphate Biosynthetic Process Vascular Endothelial Growth Factor Signaling Pathway T Cell Activation B Cell Activation Mast Cell Degranulation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Innate Immune Response Positive Regulation Of Angiogenesis Phosphatidylinositol Phosphate Biosynthetic Process Phosphatidylinositol-mediated Signaling T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of Developmental Process Positive Regulation Of Multicellular Organismal Process Mast Cell Differentiation Neutrophil Extravasation Positive Regulation Of Epithelial Tube Formation Regulation Of Multicellular Organismal Development
Pathways		None	PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane Constitutive Signaling by Aberrant PI3K in Cancer CD28 dependent PI3K/Akt signaling Interleukin-3, Interleukin-5 and GM-CSF signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Signaling by CSF1 (M-CSF) in myeloid cells Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Co-stimulation by ICOS
Drugs		None	Caffeine XL765 TG100-115 2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE Idelalisib Duvelisib Fostamatinib Copanlisib Umbralisib
GWAS		No GWAS studies recorded	Diisocyanate-induced asthma ( 25918132 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Irritable bowel syndrome ( 29626450 ) Lymphocyte count ( 32888494 ) Monocyte count ( 27863252 32888494 ) Systemising ( 31508503 ) Testicular germ cell tumor ( 28604728 )
Novel Interactors		None recorded	1 novel interactors: MTOR
Interacting Genes		4 interacting genes: MYO15B PIK3CD PIK3R1 TLX3	15 interacting genes: ASCC2 ERAS HRAS IL3 IL4 IRS2 KITLG MCRIP2 PIK3CG PIK3R1 PIK3R2 RALY SNCA TAGLN TNPO2
Entrez ID		3266	5293
HPRD ID		02339	04161
Ensembl ID		ENSG00000187682	ENSG00000171608
Uniprot IDs		Q7Z444	A0A2K8FKV1 A0A8V8TM62 A7E2E0 B7ZM44 O00329
PDB IDs		Not available	5DXU 5M6U 5T8F 5UBT 5VLR 6G6W 6OCO 6OCU 6PYR 6PYU 7JIS 7LM2 7LQ1 8BCY 8S3R 9GCF 9GDI
GO Terms Enriched among Interactors		Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA Phosphatidylinositol Phosphate Biosynthetic Process B Cell Differentiation Glycerophospholipid Biosynthetic Process Natural Killer Cell Chemotaxis Phosphatidylinositol Metabolic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Mast Cell Differentiation Regulation Of Neutrophil Apoptotic Process Positive Regulation Of Neutrophil Apoptotic Process Myeloid Leukocyte Migration Phospholipid Biosynthetic Process Leukocyte Migration Glycerophospholipid Metabolic Process Leukocyte Mediated Immunity Cell Migration Mast Cell Chemotaxis B Cell Activation T Cell Differentiation Phosphatidylinositol Biosynthetic Process Lymphocyte Differentiation Cell Motility B Cell Chemotaxis Myeloid Cell Differentiation Neutrophil Extravasation Myeloid Leukocyte Differentiation Kinase Regulator Activity Insulin Binding Perinuclear Endoplasmic Reticulum Membrane 1-phosphatidylinositol-3-kinase Regulator Activity Neurotrophin TRKA Receptor Binding Phosphatidylinositol 3-kinase Regulator Activity ErbB-3 Class Receptor Binding 1-phosphatidylinositol-4-phosphate 3-kinase Activity Mast Cell Migration 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Phosphatidylinositol 3-kinase Activator Activity Positive Regulation Of Myeloid Cell Apoptotic Process Respiratory Burst Involved In Defense Response Mononuclear Cell Differentiation Glycerolipid Metabolic Process Positive Regulation Of Epithelial Tube Formation T Cell Activation Positive Regulation Of Focal Adhesion Disassembly Phosphatidylinositol 3-kinase Regulatory Subunit Binding Phospholipid Metabolic Process 1-phosphatidylinositol-3-kinase Activity T Follicular Helper Cell Differentiation Leukocyte Differentiation	Insulin Receptor Signaling Pathway Phosphatidylinositol 3-kinase Complex, Class IA Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Negative Regulation Of Programmed Cell Death Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Locomotion Cellular Response To Insulin Stimulus Regulation Of Myeloid Leukocyte Differentiation Intracellular Signaling Cassette Regulation Of Generation Of Precursor Metabolites And Energy T Cell Activation Leukocyte Activation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Small Molecule Metabolic Process Immune System Process Regulation Of Protein Localization To Cell Periphery 1-phosphatidylinositol-3-kinase Regulator Activity Regulation Of Cell Migration Response To Insulin Regulation Of Apoptotic Process Cell Activation Phosphatidylinositol 3-kinase Activator Activity Regulation Of Cell Motility Cellular Response To Peptide Hormone Stimulus Regulation Of Programmed Cell Death Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Regulatory Subunit Binding Regulation Of Epithelial Cell Migration Regulation Of Osteoclast Differentiation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Myeloid Cell Differentiation Lymphocyte Activation Immune Response Ras Protein Signal Transduction Regulation Of Cell Adhesion Intracellular Glucose Homeostasis Protein Phosphatase Binding Regulation Of Stress Fiber Assembly Regulation Of Cytoskeleton Organization Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Protein Localization Phosphatidylinositol 3-kinase Binding Response To Peptide Hormone B Cell Differentiation Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Phosphate Metabolic Process Cell Surface Receptor Signaling Pathway