ERAS and TLX3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ERAS	TLX3
Description		ES cell expressed Ras	T cell leukemia homeobox 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Chromatin Nucleus Nucleoplasm
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Signal Transduction Ras Protein Signal Transduction	Neuron Migration Regulation Of Respiratory Gaseous Exchange By Nervous System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Respiratory Gaseous Exchange By Respiratory System Neuron Differentiation Negative Regulation Of Neuron Differentiation Animal Organ Development Neuron Fate Specification GABAergic Neuron Differentiation
Pathways
Drugs
Diseases			Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS			Body size at age 10 ( 32376654)
Interacting Genes		4 interacting genes: MYO15B PIK3CD PIK3R1 TLX3	108 interacting genes: ACTMAP ACY1 AKAP9 ANKRD10 ANKRD33 AOC1 APBB1IP ARMC5 ASB12 ATP6V0D1 B9D2 BPIFA1 C2orf42 CEACAM6 CFAP68 CIMIP2B CRX CSNK2B CTNNA3 DENND4A EFEMP2 ERAS FAM168B FCSK FNTB FOSB FOXH1 GGTLC2 GOLGA6L9 GTF2A1L H2BC11 HNF1B HNRNPUL1 HOPX HSPB2 HSPB2-C11orf52 HYI IGFL2 ING4 INTS11 IRF9 ITIH6 KCNJ5-AS1 KRT34 KRTAP11-1 KRTAP13-3 KRTAP19-1 KRTAP19-7 KRTAP3-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 LASP1 LMO2 MAGED1 MEIS1 METTL27 MORN5 MSX2 NDUFAB1 NFIC NFIX NHLRC4 NICN1 OIP5 PLA2G10 PLAAT1 POU2AF1 POU6F2 PPP1CC PQBP1 PRR20A PRR20B PRR20C PRR20D PRR20E PSMB11 REL ROR2 RSKR SERPINE1 SLC15A2 SMU1 SNTA1 SP1 SPATA46 SPMIP9 SPRYD7 STH SYNGAP1 TBX22 TCIRG1 TEKT5 THTPA TLE2 TMEM42 TOX2 TP53BP1 TRIM42 UFSP1 WDR83 YPEL3 ZBTB32 ZNF34 ZNF41 ZNF44
Entrez ID		3266	30012
HPRD ID		02339	06868
Ensembl ID		ENSG00000187682	ENSG00000164438
Uniprot IDs		Q7Z444	O43711
PDB IDs
Enriched GO Terms of Interacting Partners?		Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA Phosphatidylinositol Phosphate Biosynthetic Process B Cell Differentiation Glycerophospholipid Biosynthetic Process Natural Killer Cell Chemotaxis Phosphatidylinositol Metabolic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Mast Cell Differentiation Regulation Of Neutrophil Apoptotic Process Positive Regulation Of Neutrophil Apoptotic Process Myeloid Leukocyte Migration Phospholipid Biosynthetic Process Leukocyte Migration Glycerophospholipid Metabolic Process Leukocyte Mediated Immunity Cell Migration Mast Cell Chemotaxis B Cell Activation T Cell Differentiation Phosphatidylinositol Biosynthetic Process Lymphocyte Differentiation Cell Motility B Cell Chemotaxis Myeloid Cell Differentiation Neutrophil Extravasation Myeloid Leukocyte Differentiation Kinase Regulator Activity Insulin Binding Perinuclear Endoplasmic Reticulum Membrane 1-phosphatidylinositol-3-kinase Regulator Activity Neurotrophin TRKA Receptor Binding Phosphatidylinositol 3-kinase Regulator Activity ErbB-3 Class Receptor Binding 1-phosphatidylinositol-4-phosphate 3-kinase Activity Mast Cell Migration 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Phosphatidylinositol 3-kinase Activator Activity Positive Regulation Of Myeloid Cell Apoptotic Process Respiratory Burst Involved In Defense Response Mononuclear Cell Differentiation Glycerolipid Metabolic Process Positive Regulation Of Epithelial Tube Formation T Cell Activation Positive Regulation Of Focal Adhesion Disassembly Phosphatidylinositol 3-kinase Regulatory Subunit Binding Phospholipid Metabolic Process 1-phosphatidylinositol-3-kinase Activity T Follicular Helper Cell Differentiation Leukocyte Differentiation	Intermediate Filament Protein Binding Chromatin
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