LAMA1 and NID1

Number of citations of the paper that reports this interaction (PubMedID 8995276)
0

Data Source:
HPRD (in vitro)

		LAMA1	NID1
Description		laminin subunit alpha 1	nidogen 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-1 Complex Laminin-3 Complex Extracellular Space Cell-cell Junction Membrane Extracellular Matrix Laminin Complex Protein Complex Involved In Cell-matrix Adhesion	Extracellular Region Basement Membrane Extracellular Matrix Extracellular Exosome Cell Periphery Protein Complex Involved In Cell-matrix Adhesion
	Molecular Function	Signaling Receptor Binding Extracellular Matrix Structural Constituent Protein Binding Glycosphingolipid Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Collagen Binding Laminin Binding Laminin-1 Binding Proteoglycan Binding Extracellular Matrix Binding
	Biological Process	Morphogenesis Of An Epithelial Sheet Cell Adhesion Cell Surface Receptor Signaling Pathway Tissue Development Regulation Of Cell Adhesion Regulation Of Cell Migration Neuron Projection Development Establishment Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Cell Adhesion Regulation Of Embryonic Development Positive Regulation Of Muscle Cell Differentiation Retina Development In Camera-type Eye Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Salivary Gland Morphogenesis Retinal Blood Vessel Morphogenesis Regulation Of Basement Membrane Organization Positive Regulation Of Integrin-mediated Signaling Pathway	Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization Glomerular Basement Membrane Development Positive Regulation Of Cell Adhesion Positive Regulation Of Muscle Cell Differentiation Basement Membrane Organization Regulation Of Basement Membrane Organization Positive Regulation Of Integrin-mediated Signaling Pathway
Pathways		Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans L1CAM interactions MET activates PTK2 signaling Attachment of bacteria to epithelial cells Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Pancreatic Ductal Cells	Degradation of the extracellular matrix Degradation of the extracellular matrix Laminin interactions Laminin interactions
Drugs		Lanoteplase	Urokinase
Diseases
GWAS		Adverse response to drug ( 30420678) Response to citalopram treatment ( 22760553) Type 2 diabetes ( 22693455 30054458 30297969 32499647)	Cutaneous nevi ( 21478494) Diverticulitis ( 28585551) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Mean platelet volume ( 32888494) Response to levetiracetam in genetic generalized epilepsy ( 32308125) Urate levels in overweight individuals ( 25811787)
Interacting Genes		23 interacting genes: ACHE APCS APP C3 COL18A1 COL7A1 DAG1 FBLN2 HSPG2 ITGA1 ITGA2 ITGB1 MEP1A NID1 NT5E PLAT PLG SAA1 SAA2 TGM2 TMPRSS6 UBC USP7	21 interacting genes: APP COL13A1 COL1A1 COL4A1 FBLN1 FBLN2 FGA FGB HSPG2 ITGAV ITGB3 LACRT LAMA1 LAMC1 LAMC2 LGALS3BP PLAU PLXDC1 PRELP PTPRF SKIL
Entrez ID		284217	4811
HPRD ID		01033	00574
Ensembl ID		ENSG00000101680	ENSG00000116962
Uniprot IDs		P25391	P14543
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Laminin Binding Basement Membrane Extracellular Matrix Extracellular Region Cell Surface Extracellular Space Extracellular Matrix Organization Extracellular Structure Organization Collagen Binding Involved In Cell-matrix Adhesion Cell Adhesion External Side Of Plasma Membrane Cell-matrix Adhesion Collagen Binding Cell-substrate Adhesion Integrin Alpha1-beta1 Complex High-density Lipoprotein Particle Integrin Alpha2-beta1 Complex Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Regulation Of Cell Adhesion Integrin Complex Response To Muscle Activity Calcium Ion Binding Trans-synaptic Signaling By BDNF Basement Membrane Organization Focal Adhesion Acute-phase Response Peptidase Activity Positive Regulation Of Multicellular Organismal Process Regulation Of Spontaneous Synaptic Transmission Regulation Of Wound Healing Modulation Of Chemical Synaptic Transmission Endoplasmic Reticulum Lumen Laminin-1 Binding Positive Regulation Of Cell Adhesion Integrin Binding Serine-type Endopeptidase Activity Inflammatory Response Regulation Of Apoptotic Cell Clearance Regulation Of Response To Wounding Acute Inflammatory Response Positive Regulation Of Wound Healing Proteolysis Branching Involved In Salivary Gland Morphogenesis Negative Regulation Of Fibrinolysis Trans-synaptic Signaling, Modulating Synaptic Transmission Negative Regulation Of Wound Healing Cell Migration Regulation Of Multicellular Organismal Process Regulation Of Cell Communication	Extracellular Matrix Structural Constituent Extracellular Matrix Extracellular Region Basement Membrane Extracellular Space Blood Coagulation, Fibrin Clot Formation Regulation Of Cell Adhesion Cell Adhesion Regulation Of Cell-substrate Adhesion Protein Activation Cascade Cell-substrate Adhesion Positive Regulation Of Cell Adhesion Protein Complex Involved In Cell-matrix Adhesion Cell-matrix Adhesion Plasminogen Activation Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Signal Transduction Integrin Binding Regulation Of Substrate Adhesion-dependent Cell Spreading Extracellular Exosome Endoplasmic Reticulum Lumen Heparin Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Integrin Alphav-beta3 Complex Platelet Alpha Granule Fibrinolysis Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Integrin-mediated Signaling Pathway External Side Of Plasma Membrane Positive Regulation Of Cell Migration Extracellular Vesicle Positive Regulation Of Cell Motility Alphav-beta3 Integrin-PKCalpha Complex Alphav-beta3 Integrin-HMGB1 Complex Laminin-1 Complex Cell Adhesion Molecule Binding Positive Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Fibronectin Binding Extracellular Matrix Binding Blood Coagulation Coagulation Alphav-beta3 Integrin-IGF-1-IGF1R Complex Hemostasis Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Cell Migration Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Structural Constituent Conferring Tensile Strength
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