LAMA1 and TMPRSS6

Number of citations of the paper that reports this interaction (PubMedID 12149247)
0

Data Source:
HPRD (in vitro)

		LAMA1	TMPRSS6
Description		laminin subunit alpha 1	transmembrane serine protease 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-1 Complex Laminin-3 Complex Extracellular Space Cell-cell Junction Membrane Extracellular Matrix Laminin Complex Protein Complex Involved In Cell-matrix Adhesion	Extracellular Space Plasma Membrane Membrane
	Molecular Function	Signaling Receptor Binding Extracellular Matrix Structural Constituent Protein Binding Glycosphingolipid Binding	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Morphogenesis Of An Epithelial Sheet Cell Adhesion Cell Surface Receptor Signaling Pathway Tissue Development Regulation Of Cell Adhesion Regulation Of Cell Migration Neuron Projection Development Establishment Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Cell Adhesion Regulation Of Embryonic Development Positive Regulation Of Muscle Cell Differentiation Retina Development In Camera-type Eye Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Salivary Gland Morphogenesis Retinal Blood Vessel Morphogenesis Regulation Of Basement Membrane Organization Positive Regulation Of Integrin-mediated Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Proteolysis Intracellular Iron Ion Homeostasis Extracellular Matrix Disassembly BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Collagen Catabolic Process Membrane Protein Proteolysis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Multicellular Organismal-level Iron Ion Homeostasis Self Proteolysis
Pathways		Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans L1CAM interactions MET activates PTK2 signaling Attachment of bacteria to epithelial cells Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Pancreatic Ductal Cells	Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix
Drugs		Lanoteplase
Diseases
GWAS		Adverse response to drug ( 30420678) Response to citalopram treatment ( 22760553) Type 2 diabetes ( 22693455 30054458 30297969 32499647)	Clinical laboratory measurements ( 27897004) Femur bone mineral density x serum urate levels interaction ( 34046847) Glycated hemoglobin levels ( 34059833 31213470 28898252 20858683) Hematocrit ( 32888494 19862010 29403010 28453575 28017375 27863252) Hematological and biochemical traits ( 31902109 20139978) Hematological parameters ( 19820697) Hematology traits ( 23263863) Hemoglobin ( 29403010 19862010 28453575 19820698 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693 28017375 33491795) Hepcidin levels ( 21785125) Hepcidin/ferritin ratio ( 27846281) Hepcidin/transferrin saturation ratio ( 27846281) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Iron levels ( 19880490) Iron status biomarkers ( 19820699 19084217 21149283 21208937) Iron status biomarkers (ferritin levels) ( 33536631 28334935 25352340) Iron status biomarkers (iron levels) ( 28334935 33536631 25352340) Iron status biomarkers (total iron binding capacity) ( 33536631) Iron status biomarkers (transferrin levels) ( 25352340) Iron status biomarkers (transferrin saturation) ( 33536631 25352340) LDL cholesterol ( 30275531) Liver fibrosis and steatohepatitis severity (MRI cT1 measure) ( 32247823) Mean corpuscular hemoglobin ( 19862010 28453575 29403010 23263863 19853236 28031487 27863252 28017375 20139978 32888494) Mean corpuscular hemoglobin concentration ( 29403010 32888494 28453575 23263863 27863252 28017375 20139978) Mean corpuscular volume ( 23263863 27863252 32888494 28017375 19862010 19853236 31194788 20139978 29403010 28453575) Mean spheric corpuscular volume ( 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Red blood cell count ( 27863252 32888494) Red blood cell traits ( 20927387 23222517 23935956) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Total bilirubin levels ( 29403010) Triglyceride levels ( 32203549 32154731)
Interacting Genes		23 interacting genes: ACHE APCS APP C3 COL18A1 COL7A1 DAG1 FBLN2 HSPG2 ITGA1 ITGA2 ITGB1 MEP1A NID1 NT5E PLAT PLG SAA1 SAA2 TGM2 TMPRSS6 UBC USP7	4 interacting genes: CFTR COL1A1 FN1 LAMA1
Entrez ID		284217	164656
HPRD ID		01033	10270
Ensembl ID		ENSG00000101680	ENSG00000187045
Uniprot IDs		P25391	Q8IU80
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Laminin Binding Basement Membrane Extracellular Matrix Extracellular Region Cell Surface Extracellular Space Extracellular Matrix Organization Extracellular Structure Organization Collagen Binding Involved In Cell-matrix Adhesion Cell Adhesion External Side Of Plasma Membrane Cell-matrix Adhesion Collagen Binding Cell-substrate Adhesion Integrin Alpha1-beta1 Complex High-density Lipoprotein Particle Integrin Alpha2-beta1 Complex Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Regulation Of Cell Adhesion Integrin Complex Response To Muscle Activity Calcium Ion Binding Trans-synaptic Signaling By BDNF Basement Membrane Organization Focal Adhesion Acute-phase Response Peptidase Activity Positive Regulation Of Multicellular Organismal Process Regulation Of Spontaneous Synaptic Transmission Regulation Of Wound Healing Modulation Of Chemical Synaptic Transmission Endoplasmic Reticulum Lumen Laminin-1 Binding Positive Regulation Of Cell Adhesion Integrin Binding Serine-type Endopeptidase Activity Inflammatory Response Regulation Of Apoptotic Cell Clearance Regulation Of Response To Wounding Acute Inflammatory Response Positive Regulation Of Wound Healing Proteolysis Branching Involved In Salivary Gland Morphogenesis Negative Regulation Of Fibrinolysis Trans-synaptic Signaling, Modulating Synaptic Transmission Negative Regulation Of Wound Healing Cell Migration Regulation Of Multicellular Organismal Process Regulation Of Cell Communication	Extracellular Matrix Structural Constituent Positive Regulation Of Developmental Process Extracellular Matrix Positive Regulation Of Cell Communication Positive Regulation Of Signaling Response To CAMP Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Cellular Response To Vitamin E Protease Binding Basement Membrane Response To Purine-containing Compound Positive Regulation Of Anion Channel Activity Anatomical Structure Formation Involved In Morphogenesis Regulation Of Developmental Process Collagen Type I Trimer Regulation Of Cell Adhesion Cellular Response To Fluoride Positive Regulation Of Monoatomic Anion Transport Regulation Of Cell Migration Positive Regulation Of Cell Differentiation Negative Regulation Of Monocyte Activation Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Laminin-1 Complex Laminin-3 Complex Regulation Of Multicellular Organismal Process Cellular Developmental Process Positive Regulation Of Enamel Mineralization Regulation Of Cell Motility Regulation Of Locomotion Response To Fluoride Calcium-independent Cell-matrix Adhesion Laminin Complex Regulation Of Cell-substrate Adhesion Transepithelial Water Transport Positive Regulation Of Tooth Mineralization Intramembranous Ossification Neural Crest Cell Migration Involved In Autonomic Nervous System Development Retinal Blood Vessel Morphogenesis Glycosphingolipid Binding Regulation Of Cell Communication Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Signaling Regulation Of Enamel Mineralization Membrane Hyperpolarization Response To Vitamin E Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation
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