LAMA1 and TMPRSS6

Number of citations of the paper that reports this interaction (PMID 12149247)
44

Data Source:
HPRD (in vitro)

		LAMA1	TMPRSS6
Gene Name		laminin, alpha 1	transmembrane protease, serine 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Basement Membrane Laminin-1 Complex Laminin-3 Complex Extracellular Space Cell-cell Junction Extracellular Matrix	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Receptor Binding Extracellular Matrix Structural Constituent Protein Binding Glycosphingolipid Binding	Serine-type Endopeptidase Activity Protein Binding
	Biological Process	Morphogenesis Of An Epithelial Sheet Cell Adhesion Cell Surface Receptor Signaling Pathway Axon Guidance Regulation Of Cell Adhesion Extracellular Matrix Organization Regulation Of Cell Migration Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of Embryonic Development Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Salivary Gland Morphogenesis Retinal Blood Vessel Morphogenesis	Angiogenesis Proteolysis Extracellular Matrix Organization Negative Regulation Of BMP Signaling Pathway Intracellular Signal Transduction Fibrinolysis Iron Ion Homeostasis
Pathways		Axon guidance Laminin interactions ECM proteoglycans L1CAM interactions Non-integrin membrane-ECM interactions
Drugs
Diseases
GWAS		Response to citalopram treatment ( 22760553) Type 2 diabetes ( 22693455)	Glycated hemoglobin levels ( 20858683) Hematocrit ( 19862010) Hematological and biochemical traits ( 20139978) Hematological parameters ( 19820697) Hematology traits ( 23263863 19853236) Hemoglobin ( 19820698 19862010) Hepcidin levels ( 21785125) Iron levels ( 19880490 21208937) Iron status biomarkers ( 21149283 19820699 19084217) Mean corpuscular hemoglobin ( 23263863 20139978 19862010) Mean corpuscular hemoglobin concentration ( 23263863 20139978) Mean corpuscular volume ( 23263863 20139978 19862010) Red blood cell traits ( 20927387 23222517)
Protein-Protein Interactions		19 interactors: ACHE APCS APP C3 COL7A1 DAG1 FBLN2 HSPG2 ITGA1 ITGA2 ITGB1 MEP1A NID1 NT5E PLAT PLG SAA1 SAA2 TMPRSS6	3 interactors: COL1A1 FN1 LAMA1
Entrez ID		284217	164656
HPRD ID		01033	10270
Ensembl ID		ENSG00000101680	ENSG00000187045
Uniprot IDs		P25391	Q8IU80
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Blood Coagulation Hemostasis Response To Wounding Cell-matrix Adhesion Regulation Of Body Fluid Levels Negative Regulation Of Wound Healing Wound Healing Cell-substrate Adhesion Extracellular Matrix Disassembly Cell Adhesion Fibrinolysis Regulation Of Inflammatory Response Locomotion Regulation Of Wound Healing Acute-phase Response Viral Entry Into Host Cell Chemotaxis Entry Into Host Cell Regulation Of Cell Adhesion Positive Regulation Of Cell Adhesion Movement Of Cell Or Subcellular Component Axon Guidance Negative Regulation Of Blood Coagulation Response To Stress Regulation Of Cell-substrate Adhesion Negative Regulation Of Coagulation Acute Inflammatory Response Leukocyte Migration Cell Migration Axonogenesis Cell Motility Cell Adhesion Mediated By Integrin Basement Membrane Organization Axon Development Positive Regulation Of Endocytosis Regulation Of Blood Coagulation Cell Morphogenesis Involved In Neuron Differentiation Interaction With Host Negative Regulation Of Inflammatory Response Positive Regulation Of Cell-substrate Adhesion Integrin-mediated Signaling Pathway Neuron Projection Morphogenesis Regulation Of Protein Metabolic Process Formation Of Primary Germ Layer Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Cell Morphogenesis Involved In Differentiation Positive Regulation Of Transport	Extracellular Matrix Organization Extracellular Structure Organization Blood Vessel Development Vasculature Development Extracellular Matrix Disassembly Cardiovascular System Development Cellular Response To Fluoride Positive Regulation Of Cell Morphogenesis Involved In Differentiation Locomotion Platelet Activation Tooth Eruption Response To Fluoride Movement Of Cell Or Subcellular Component Leukocyte Migration Tissue Development Calcium-independent Cell-matrix Adhesion Retinal Blood Vessel Morphogenesis Cellular Response To Vitamin E Establishment Of Epithelial Cell Apical/basal Polarity Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Blood Coagulation Blood Vessel Morphogenesis Hemostasis Anatomical Structure Morphogenesis Regulation Of Cell Morphogenesis Establishment Of Monopolar Cell Polarity Intramembranous Ossification Tooth Mineralization Positive Regulation Of Cell Development Bone Trabecula Formation Protein Heterotrimerization Integrin Activation Retina Vasculature Morphogenesis In Camera-type Eye Collagen Biosynthetic Process Regulation Of Body Fluid Levels Regulation Of Cell Migration Wound Healing Regulation Of Cell Adhesion Regulation Of Cell Motility Establishment Of Epithelial Cell Polarity Bone Trabecula Morphogenesis Regulation Of Locomotion Cell Activation Response To Vitamin E Regulation Of Cellular Component Movement Response To Wounding Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell Morphogenesis Involved In Differentiation Retina Vasculature Development In Camera-type Eye
Tagcloud ?		annexin2 col1a1 committed desensitized ecm fbln1 fbn2 fibrillin fibullin fn1 has1 hsc hyaluronan ifi ifi44l ifit1 ifnbeta isgf3 laminin mineralization modifies niche opn osteoblast osteoblasts osteoimmunology osteopontin pinpoints timing	addressed africa allele anaemia breastfeeding comparatively falciparum ferritin haematological haemoglobin hb household id income odds outweigh plasmodium preventable rs855791 rural rwanda rwandan saharan southern substantially tended thalassaemia uncommon verified
Tagcloud (Difference) ?		annexin2 col1a1 committed desensitized ecm fbln1 fbn2 fibrillin fibullin fn1 has1 hsc hyaluronan ifi ifi44l ifit1 ifnbeta isgf3 laminin mineralization modifies niche opn osteoblast osteoblasts osteoimmunology osteopontin pinpoints timing	addressed africa allele anaemia breastfeeding comparatively falciparum ferritin haematological haemoglobin hb household id income odds outweigh plasmodium preventable rs855791 rural rwanda rwandan saharan southern substantially tended thalassaemia uncommon verified
Tagcloud (Intersection) ?