LAMA1 and NT5E

Number of citations of the paper that reports this interaction (PMID 10470109)
9

Data Source:
HPRD (in vivo)

		LAMA1	NT5E
Gene Name		laminin, alpha 1	5-nucleotidase, ecto (CD73)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Basement Membrane Laminin-1 Complex Laminin-3 Complex Extracellular Space Cell-cell Junction Extracellular Matrix	Cytoplasm Plasma Membrane Cell Surface Membrane Anchored Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Extracellular Matrix Structural Constituent Protein Binding Glycosphingolipid Binding	Nucleotide Binding 5'-nucleotidase Activity Metal Ion Binding
	Biological Process	Morphogenesis Of An Epithelial Sheet Cell Adhesion Cell Surface Receptor Signaling Pathway Axon Guidance Regulation Of Cell Adhesion Extracellular Matrix Organization Regulation Of Cell Migration Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of Embryonic Development Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Salivary Gland Morphogenesis Retinal Blood Vessel Morphogenesis	Purine Nucleobase Metabolic Process Purine Nucleotide Catabolic Process AMP Catabolic Process Pyrimidine Nucleobase Metabolic Process DNA Metabolic Process Dephosphorylation Small Molecule Metabolic Process Adenosine Biosynthetic Process Pyrimidine Nucleoside Catabolic Process Negative Regulation Of Inflammatory Response Nucleobase-containing Small Molecule Metabolic Process
Pathways		Axon guidance Laminin interactions ECM proteoglycans L1CAM interactions Non-integrin membrane-ECM interactions	Purine catabolism Pyrimidine catabolism Purine metabolism Pyrimidine metabolism Metabolism of nucleotides
Drugs			Pentoxifylline
Diseases
GWAS		Response to citalopram treatment ( 22760553) Type 2 diabetes ( 22693455)	Metabolic traits ( 21886157)
Protein-Protein Interactions		19 interactors: ACHE APCS APP C3 COL7A1 DAG1 FBLN2 HSPG2 ITGA1 ITGA2 ITGB1 MEP1A NID1 NT5E PLAT PLG SAA1 SAA2 TMPRSS6	4 interactors: ACTB AFF1 FN1 LAMA1
Entrez ID		284217	4907
HPRD ID		01033	00552
Ensembl ID		ENSG00000101680	ENSG00000135318
Uniprot IDs		P25391	P21589 Q6NZX3
PDB IDs			4H1S 4H1Y 4H2B 4H2F 4H2G 4H2I
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Blood Coagulation Hemostasis Response To Wounding Cell-matrix Adhesion Regulation Of Body Fluid Levels Negative Regulation Of Wound Healing Wound Healing Cell-substrate Adhesion Extracellular Matrix Disassembly Cell Adhesion Fibrinolysis Regulation Of Inflammatory Response Locomotion Regulation Of Wound Healing Acute-phase Response Viral Entry Into Host Cell Chemotaxis Entry Into Host Cell Regulation Of Cell Adhesion Positive Regulation Of Cell Adhesion Movement Of Cell Or Subcellular Component Axon Guidance Negative Regulation Of Blood Coagulation Response To Stress Regulation Of Cell-substrate Adhesion Negative Regulation Of Coagulation Acute Inflammatory Response Leukocyte Migration Cell Migration Axonogenesis Cell Motility Cell Adhesion Mediated By Integrin Basement Membrane Organization Axon Development Positive Regulation Of Endocytosis Regulation Of Blood Coagulation Cell Morphogenesis Involved In Neuron Differentiation Interaction With Host Negative Regulation Of Inflammatory Response Positive Regulation Of Cell-substrate Adhesion Integrin-mediated Signaling Pathway Neuron Projection Morphogenesis Regulation Of Protein Metabolic Process Formation Of Primary Germ Layer Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Cell Morphogenesis Involved In Differentiation Positive Regulation Of Transport	Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Platelet Activation Cell Junction Assembly Cell Adhesion Locomotion Calcium-independent Cell-matrix Adhesion Retinal Blood Vessel Morphogenesis Establishment Of Epithelial Cell Apical/basal Polarity Movement Of Cell Or Subcellular Component Generation Of Neurons Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Neurogenesis Extracellular Matrix Organization Extracellular Structure Organization Axon Guidance Establishment Of Monopolar Cell Polarity Cell Development Blood Coagulation Blood Vessel Morphogenesis Hemostasis Integrin Activation Retina Vasculature Morphogenesis In Camera-type Eye Blood Vessel Development Axonogenesis Establishment Of Epithelial Cell Polarity Vasculature Development Axon Development Nervous System Development Regulation Of Body Fluid Levels Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Chemotaxis Retina Vasculature Development In Camera-type Eye Anatomical Structure Morphogenesis Morphogenesis Of A Polarized Epithelium Neuron Projection Morphogenesis Establishment Or Maintenance Of Apical/basal Cell Polarity Cell Activation Response To Wounding Branching Involved In Salivary Gland Morphogenesis Substantia Nigra Development Endodermal Cell Differentiation Platelet Aggregation Acute-phase Response Neuron Projection Development Positive Regulation Of Axon Extension Cell Projection Morphogenesis
Tagcloud ?		annexin2 col1a1 committed desensitized ecm fbln1 fbn2 fibrillin fibullin fn1 has1 hsc hyaluronan ifi ifi44l ifit1 ifnbeta isgf3 laminin mineralization modifies niche opn osteoblast osteoblasts osteoimmunology osteopontin pinpoints timing	amphiregulin areg betacellulin btc calgb cd73 cetuximab chemo dusp4 epgn epigen epiregulin erbb3 erbb4 ereg folfiri folfox formalin hbegf her3 her4 implicate kras mcrc modeled multiplicative pfs phlda1 tgfa
Tagcloud (Difference) ?		annexin2 col1a1 committed desensitized ecm fbln1 fbn2 fibrillin fibullin fn1 has1 hsc hyaluronan ifi ifi44l ifit1 ifnbeta isgf3 laminin mineralization modifies niche opn osteoblast osteoblasts osteoimmunology osteopontin pinpoints timing	amphiregulin areg betacellulin btc calgb cd73 cetuximab chemo dusp4 epgn epigen epiregulin erbb3 erbb4 ereg folfiri folfox formalin hbegf her3 her4 implicate kras mcrc modeled multiplicative pfs phlda1 tgfa
Tagcloud (Intersection) ?