KIFAP3 and MYPOP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KIFAP3	MYPOP
Description		kinesin associated protein 3	Myb related transcription factor, partner of profilin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Condensed Nuclear Chromosome Photoreceptor Outer Segment Photoreceptor Inner Segment Endoplasmic Reticulum Golgi Apparatus Centrosome Cytosol Kinesin Complex Spindle Microtubule Cilium Axoneme Microtubule Cytoskeleton Kinesin II Complex Photoreceptor Connecting Cilium Dendrite Cytoplasm Ciliary Transition Zone Ciliary Basal Body Ciliary Tip Postsynapse Glutamatergic Synapse Periciliary Membrane Compartment	Nucleus
	Molecular Function	Protein Binding Kinesin Binding Protein Phosphatase Binding Intraciliary Transport Particle B Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding
	Biological Process	Apoptotic Process Microtubule-based Process Microtubule-based Movement Signal Transduction Neuroblast Proliferation Negative Regulation Of Neuroblast Proliferation Intracellular Protein Localization Cell Population Proliferation Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Apoptotic Process Cilium Organization Positive Regulation Of Calcium-dependent Cell-cell Adhesion Protein-containing Complex Assembly Thymocyte Apoptotic Process Negative Regulation Of Thymocyte Apoptotic Process Plus-end-directed Vesicle Transport Along Microtubule Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane MHC class II antigen presentation Intraflagellar transport COPI-dependent Golgi-to-ER retrograde traffic Kinesins Kinesins
Drugs
Diseases
GWAS		Acute anterior uveitis in ankylosing spondylitis ( 32492107) Adverse response to drug ( 30420678) Amyotrophic lateral sclerosis ( 19451621) Atrial fibrillation ( 28416818) L-selectin levels ( 25576479) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Asthma ( 31959851)
Interacting Genes		33 interacting genes: APC AR C19orf44 CCSER2 DHX37 DISC1 GTSE1 HOXB5 KANK2 KIF3B MAP3K10 MAP3K11 MARK2 MEST MINK1 MOS MYPOP NAA10 NAA11 NAV1 NCF2 NIPSNAP3A NUDT21 PARD6G PEX19 PRNP RAP1GDS1 RBFOX1 RBM14 RPGR RTP5 SMC3 SRC	42 interacting genes: AKAP8L BAG4 BBC3 CARD10 CHIC2 CIB4 CYSRT1 FHL3 HNRNPH1 HNRNPK HOXA1 KHDRBS3 KIFAP3 KRT40 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP19-5 KRTAP19-6 KRTAP3-1 KRTAP5-6 MDFI MTUS2 NBPF19 NCK2 NECAB2 NOTCH2NLA PFN1 PFN2 PRDM14 PRR3 RBM3 RBMX RBMY1A1 RBPMS2 SAT1 SYNCRIP TGM1 TNS2 TRA2B
Entrez ID		22920	339344
HPRD ID		03499	17352
Ensembl ID		ENSG00000075945	ENSG00000176182
Uniprot IDs		A0AAQ5BGI3 Q92845	Q86VE0
PDB IDs
Enriched GO Terms of Interacting Partners?		Microtubule-based Process Protein Autophosphorylation Protein-N-terminal-alanine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity Cytoplasm Organelle Organization MAP Kinase Kinase Kinase Activity Protein N-terminal-serine Acetyltransferase Activity Cytoskeleton Organization ATPase Binding Microtubule Cytoskeleton Organization NatA Complex Microtubule Regulation Of Intracellular Estrogen Receptor Signaling Pathway Protein-N-terminal Amino-acid Acetyltransferase Activity MAPK Cascade Regulation Of Protein Serine/threonine Kinase Activity Microtubule Binding Microtubule Cytoskeleton JUN Kinase Kinase Kinase Activity Negative Regulation Of Cell Cycle Process Membraneless Organelle Assembly Positive Regulation Of Protein Serine/threonine Kinase Activity Centrosome Positive Regulation Of MAPK Cascade JNK Cascade Positive Regulation Of JUN Kinase Activity N-terminal Protein Amino Acid Acetylation Regulation Of MAPK Cascade Protein Binding Cytoskeleton Organelle Assembly Protein Kinase Activity Intracellular Signal Transduction Lamin Binding Negative Regulation Of Chromosome Organization Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Protein Phosphorylation Negative Regulation Of Cell Cycle Protein Serine Kinase Activity Angiotensin-activated Signaling Pathway Dynein Complex Binding Mitochondrial Calcium Ion Homeostasis Phosphorylation Protein Serine/threonine Kinase Activity Positive Regulation Of JNK Cascade Regulation Of Protein Kinase Activity ATP Binding Kinase Activity Regulation Of Chromosome Organization	Intermediate Filament Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process Keratin Filament Spliceosomal Complex Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of RNA Splicing Positive Regulation Of Actin Filament Polymerization RNA Binding Nucleic Acid Binding MRNA Processing Identical Protein Binding RNA Splicing MRNA Binding Positive Regulation Of Protein Polymerization Catalytic Step 2 Spliceosome MRNA Metabolic Process MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Metabolic Process Positive Regulation Of Protein-containing Complex Assembly RNA Splicing, Via Transesterification Reactions RNA Processing Regulation Of Actin Filament Polymerization Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of MRNA Metabolic Process Regulation Of Thymocyte Apoptotic Process Positive Regulation Of Actin Filament Bundle Assembly Protein Binding Adenyl-nucleotide Exchange Factor Activity Positive Regulation Of Supramolecular Fiber Organization Modification Of Postsynaptic Structure Positive Regulation Of Cytoskeleton Organization Negative Regulation Of MRNA Splicing, Via Spliceosome Modification Of Synaptic Structure Actin Monomer Binding Regulation Of Stress Fiber Assembly Ribonucleoprotein Complex Protein Domain Specific Binding Negative Regulation Of RNA Splicing Semicircular Canal Formation Spermidine Binding Negative Regulation Of MRNA Modification T Cell Apoptotic Process Positive Regulation Of Calcium-dependent Cell-cell Adhesion
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