KIFAP3 and RAP1GDS1

Number of citations of the paper that reports this interaction (PMID 8900189)
13

Data Source:
BioGRID (pull down, two hybrid)
HPRD (in vitro, two hybrid)

		KIFAP3	RAP1GDS1
Gene Name		kinesin-associated protein 3	RAP1, GTP-GDP dissociation stimulator 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Nuclear Chromosome Endoplasmic Reticulum Golgi Apparatus Centrosome Cytosol Spindle Microtubule Axoneme Microtubule Cytoskeleton Kinesin II Complex Intraciliary Transport Particle Photoreceptor Connecting Cilium Ciliary Basal Body Extracellular Vesicular Exosome Primary Cilium Ciliary Tip Periciliary Membrane Compartment	Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Kinesin Binding	GTPase Activator Activity
	Biological Process	Protein Complex Assembly Organelle Organization Microtubule-based Process Microtubule-based Movement Signal Transduction Blood Coagulation Protein Localization Negative Regulation Of Cell Proliferation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Apoptotic Process Positive Regulation Of Calcium-dependent Cell-cell Adhesion Membrane Organization Plus-end-directed Vesicle Transport Along Microtubule	Vascular Smooth Muscle Contraction Myosin Filament Assembly Positive Regulation Of Rho GTPase Activity Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of Mitochondrial Calcium Ion Concentration
Pathways		Organelle biogenesis and maintenance MHC class II antigen presentation Kinesins Translocation of GLUT4 to the plasma membrane Assembly of the primary cilium Factors involved in megakaryocyte development and platelet production Intraflagellar transport Adaptive Immune System
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 19451621)	Biochemical measures ( 19260141)
Protein-Protein Interactions		18 interactors: APC AR DISC1 KIF3B MAP3K10 MAP3K11 MEST MINK1 NAA10 NCF2 NIPSNAP3A NUDT21 PEX19 RAP1GDS1 RBFOX1 RPGR SMC3 SRC	13 interactors: CDC42 DOC2A EGFR HRAS KIFAP3 KRAS MBIP NRAS PLEKHB1 RAC1 RAP1A RHOA ZNF451
Entrez ID		22920	5910
HPRD ID		03499	11763
Ensembl ID		ENSG00000075945	ENSG00000138698
Uniprot IDs		Q92845	B3KNU0 P52306 Q6U7G8
PDB IDs
Enriched GO Terms of Interacting Partners?		Organelle Organization Cytoskeleton Organization Microtubule-based Process Activation Of JNKK Activity Protein Autophosphorylation JNK Cascade Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Protein Complex Assembly Positive Regulation Of Cell Death Regulation Of MAPK Cascade Mitochondrial Calcium Ion Homeostasis Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of JNK Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Signal Transduction Positive Regulation Of Wnt Signaling Pathway Cellular Component Assembly Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Regulation Of JNK Cascade Positive Regulation Of MAPK Cascade Microtubule Cytoskeleton Organization Positive Regulation Of Phosphorylation Regulation Of Signal Transduction Regulation Of Stress-activated MAPK Cascade Regulation Of Apoptotic Process Activation Of JUN Kinase Activity Regulation Of Phosphorus Metabolic Process Cellular Response To Stress Positive Regulation Of MAP Kinase Activity Mitotic Spindle Organization Regulation Of Cell Death MAPK Cascade Response To Progesterone Regulation Of Signaling Regulation Of Catalytic Activity Negative Regulation Of Integrin Biosynthetic Process Negative Regulation Of Lipid Binding Positive Regulation Of Neuron Apoptotic Process Activation Of Protein Kinase Activity Regulation Of Intracellular Signal Transduction Activation Of MAPKK Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction By Phosphorylation Regulation Of Metabolic Process T Cell Differentiation In Thymus Intracellular Steroid Hormone Receptor Signaling Pathway	Neurotrophin TRK Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin Signaling Pathway Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Activation Of MAPKK Activity Wound Healing Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Response To Wounding Positive Regulation Of Rac Protein Signal Transduction Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Kinase Activity Fc Receptor Signaling Pathway Axonogenesis Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Transferase Activity Axon Development Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Response To Growth Factor Chemotaxis Small GTPase Mediated Signal Transduction Regulation Of MAPK Cascade Neuron Projection Morphogenesis Regulation Of Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Ras Protein Signal Transduction Epithelium Development Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Phosphorylation Cell Morphogenesis Involved In Differentiation Regulation Of Intracellular Signal Transduction Regulation Of Protein Kinase Activity Positive Regulation Of DNA Replication Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Ras Protein Signal Transduction Neuron Projection Development Regulation Of Phosphorylation Immune Response-regulating Signaling Pathway Leukocyte Migration Fc-epsilon Receptor Signaling Pathway Cell Migration Cell Projection Morphogenesis
Tagcloud ?		als amyotrophic angiogenin contributors decade deterioration determinant devastating directions discoveries extends extensively familial fifth fus incurable lifespan linking occurs progresses prolong riluzole sod1 sought sporadic therapeutics tls typically unc13a	adapted af4 aml1 b2a2 b3a2 considerations consuming correspondence e1a2 e2a enl evaluable expensive laborious leukemic lymphoblastic mll multicenter multiplex nup98 p190 p210 pallisgaard pbx1 rt sil strengthen tal1 tel
Tagcloud (Difference) ?		als amyotrophic angiogenin contributors decade deterioration determinant devastating directions discoveries extends extensively familial fifth fus incurable lifespan linking occurs progresses prolong riluzole sod1 sought sporadic therapeutics tls typically unc13a	adapted af4 aml1 b2a2 b3a2 considerations consuming correspondence e1a2 e2a enl evaluable expensive laborious leukemic lymphoblastic mll multicenter multiplex nup98 p190 p210 pallisgaard pbx1 rt sil strengthen tal1 tel
Tagcloud (Intersection) ?