KIFAP3 and RPGR

Number of citations of the paper that reports this interaction (PMID 16043481)
39

Data Source:
HPRD (in vivo)

		KIFAP3	RPGR
Gene Name		kinesin-associated protein 3	retinitis pigmentosa GTPase regulator
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Nuclear Chromosome Endoplasmic Reticulum Golgi Apparatus Centrosome Cytosol Spindle Microtubule Axoneme Microtubule Cytoskeleton Kinesin II Complex Intraciliary Transport Particle Photoreceptor Connecting Cilium Ciliary Basal Body Extracellular Vesicular Exosome Primary Cilium Ciliary Tip Periciliary Membrane Compartment	Photoreceptor Outer Segment Golgi Apparatus Centrosome Ciliary Basal Body Sperm Flagellum
	Molecular Function	Protein Binding Kinesin Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Poly(A) RNA Binding
	Biological Process	Protein Complex Assembly Organelle Organization Microtubule-based Process Microtubule-based Movement Signal Transduction Blood Coagulation Protein Localization Negative Regulation Of Cell Proliferation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Apoptotic Process Positive Regulation Of Calcium-dependent Cell-cell Adhesion Membrane Organization Plus-end-directed Vesicle Transport Along Microtubule	Intracellular Protein Transport Visual Perception Intraciliary Transport Cilium Assembly Eye Photoreceptor Cell Development Positive Regulation Of GTPase Activity Response To Stimulus
Pathways		Organelle biogenesis and maintenance MHC class II antigen presentation Kinesins Translocation of GLUT4 to the plasma membrane Assembly of the primary cilium Factors involved in megakaryocyte development and platelet production Intraflagellar transport Adaptive Immune System
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 19451621)
Protein-Protein Interactions		18 interactors: APC AR DISC1 KIF3B MAP3K10 MAP3K11 MEST MINK1 NAA10 NCF2 NIPSNAP3A NUDT21 PEX19 RAP1GDS1 RBFOX1 RPGR SMC3 SRC	13 interactors: DCTN1 DCTN2 IFT88 KIF3A KIFAP3 NPM1 PDE6D RPGRIP1 SLC25A10 SMC1A SMC3 TUBG1 YWHAE
Entrez ID		22920	6103
HPRD ID		03499	02425
Ensembl ID		ENSG00000075945	ENSG00000156313
Uniprot IDs		Q92845	Q92834
PDB IDs			4JHN 4JHP
Enriched GO Terms of Interacting Partners?		Organelle Organization Cytoskeleton Organization Microtubule-based Process Activation Of JNKK Activity Protein Autophosphorylation JNK Cascade Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Protein Complex Assembly Positive Regulation Of Cell Death Regulation Of MAPK Cascade Mitochondrial Calcium Ion Homeostasis Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of JNK Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Signal Transduction Positive Regulation Of Wnt Signaling Pathway Cellular Component Assembly Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Regulation Of JNK Cascade Positive Regulation Of MAPK Cascade Microtubule Cytoskeleton Organization Positive Regulation Of Phosphorylation Regulation Of Signal Transduction Regulation Of Stress-activated MAPK Cascade Regulation Of Apoptotic Process Activation Of JUN Kinase Activity Regulation Of Phosphorus Metabolic Process Cellular Response To Stress Positive Regulation Of MAP Kinase Activity Mitotic Spindle Organization Regulation Of Cell Death MAPK Cascade Response To Progesterone Regulation Of Signaling Regulation Of Catalytic Activity Negative Regulation Of Integrin Biosynthetic Process Negative Regulation Of Lipid Binding Positive Regulation Of Neuron Apoptotic Process Activation Of Protein Kinase Activity Regulation Of Intracellular Signal Transduction Activation Of MAPKK Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction By Phosphorylation Regulation Of Metabolic Process T Cell Differentiation In Thymus Intracellular Steroid Hormone Receptor Signaling Pathway	Microtubule-based Process Organelle Organization Microtubule Cytoskeleton Organization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Epidermal Stem Cell Homeostasis Cell Cycle Process G2/M Transition Of Mitotic Cell Cycle Spindle Organization Mitotic Cell Cycle Process Mitotic Cell Cycle Mitotic Spindle Organization Cell Cycle Negative Regulation Of DNA Endoreduplication Establishment Of Vesicle Localization Plus-end-directed Vesicle Transport Along Microtubule Vesicle Localization Antigen Processing And Presentation Of Peptide Antigen Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of DNA Endoreduplication Antigen Processing And Presentation Cytoskeleton Organization Mitotic Sister Chromatid Cohesion Mitotic Nuclear Division Establishment Of Organelle Localization Establishment Of Localization In Cell Microtubule-based Transport Inner Ear Receptor Stereocilium Organization Cytoskeleton-dependent Intracellular Transport Organelle Localization Intracellular Transport Sister Chromatid Cohesion Cellular Localization Response To Stress Melanosome Transport Pigment Granule Transport Establishment Of Melanosome Localization Vesicle Transport Along Microtubule Cytoplasmic Microtubule Organization Meiotic Cell Cycle Melanosome Localization Inner Ear Receptor Cell Development Negative Regulation Of DNA Replication Organelle Transport Along Microtubule Cellular Pigmentation Inner Ear Receptor Cell Differentiation Microtubule-based Movement Regulation Of Endoribonuclease Activity
Tagcloud ?		als amyotrophic angiogenin contributors decade deterioration determinant devastating directions discoveries extends extensively familial fifth fus incurable lifespan linking occurs progresses prolong riluzole sod1 sought sporadic therapeutics tls typically unc13a	acuity carriers decade erg examinations eye fields genotypically gtpase hemi identifiable kindred lys756del2aaag minimally oct ophthalmic orf15 perception phenotypically pigmentosa plottable profound puerto retinitis rican spearman teens visual
Tagcloud (Difference) ?		als amyotrophic angiogenin contributors deterioration determinant devastating directions discoveries extends extensively familial fifth fus incurable lifespan linking occurs progresses prolong riluzole sod1 sought sporadic therapeutics tls typically unc13a	acuity carriers erg examinations eye fields genotypically gtpase hemi identifiable kindred lys756del2aaag minimally oct ophthalmic orf15 perception phenotypically pigmentosa plottable profound puerto retinitis rican spearman teens visual
Tagcloud (Intersection) ?		decade