KIFAP3 and MAP3K11

Number of citations of the paper that reports this interaction (PubMedID 9427749)
51

Data Source:
BioGRID (two hybrid)

		KIFAP3	MAP3K11
Description		kinesin associated protein 3	mitogen-activated protein kinase kinase kinase 11
Image		No pdb structure
GO Annotations	Cellular Component	Condensed Nuclear Chromosome Photoreceptor Outer Segment Photoreceptor Inner Segment Endoplasmic Reticulum Golgi Apparatus Centrosome Cytosol Kinesin Complex Spindle Microtubule Cilium Axoneme Microtubule Cytoskeleton Kinesin II Complex Photoreceptor Connecting Cilium Dendrite Cytoplasm Ciliary Transition Zone Ciliary Basal Body Ciliary Tip Postsynapse Glutamatergic Synapse Periciliary Membrane Compartment	Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Membrane
	Molecular Function	Protein Binding Kinesin Binding Protein Phosphatase Binding Intraciliary Transport Particle B Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Small GTPase Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine Kinase Activity
	Biological Process	Apoptotic Process Microtubule-based Process Microtubule-based Movement Signal Transduction Neuroblast Proliferation Negative Regulation Of Neuroblast Proliferation Intracellular Protein Localization Cell Population Proliferation Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Apoptotic Process Cilium Organization Positive Regulation Of Calcium-dependent Cell-cell Adhesion Protein-containing Complex Assembly Thymocyte Apoptotic Process Negative Regulation Of Thymocyte Apoptotic Process Plus-end-directed Vesicle Transport Along Microtubule Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex	MAPK Cascade Protein Phosphorylation Microtubule-based Process JNK Cascade Positive Regulation Of Apoptotic Process Positive Regulation Of JUN Kinase Activity Positive Regulation Of Neuron Apoptotic Process Cell Cycle G1/S Phase Transition Positive Regulation Of JNK Cascade Protein Autophosphorylation
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane MHC class II antigen presentation Intraflagellar transport COPI-dependent Golgi-to-ER retrograde traffic Kinesins Kinesins	RAF activation Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF CDC42 GTPase cycle RHOG GTPase cycle RHOV GTPase cycle Signaling downstream of RAS mutants
Drugs			Fostamatinib
Diseases
GWAS		Acute anterior uveitis in ankylosing spondylitis ( 32492107) Adverse response to drug ( 30420678) Amyotrophic lateral sclerosis ( 19451621) Atrial fibrillation ( 28416818) L-selectin levels ( 25576479) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Acne (severe) ( 24927181 30542056) Coronary artery disease ( 29212778) Eosinophil count ( 27863252) Estimated glomerular filtration rate ( 31015462) Gout ( 25646370) Mean platelet volume ( 27863252) Refractive error ( 32231278) Serum uric acid levels ( 32514006) Sum eosinophil basophil counts ( 27863252) Type 2 diabetes ( 28566273 30297969) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		33 interacting genes: APC AR C19orf44 CCSER2 DHX37 DISC1 GTSE1 HOXB5 KANK2 KIF3B MAP3K10 MAP3K11 MARK2 MEST MINK1 MOS MYPOP NAA10 NAA11 NAV1 NCF2 NIPSNAP3A NUDT21 PARD6G PEX19 PRNP RAP1GDS1 RBFOX1 RBM14 RPGR RTP5 SMC3 SRC	29 interacting genes: AKT1 APP CDC42 CHUK CLEC4G COPS5 DSCAM EPS8 IKBKB KIF17 KIF3A KIF3B KIFAP3 LATS1 MAP2K4 MAP2K7 MAP3K12 MAP3K21 MAP4K1 MAP4K2 MAPK8IP1 MAPK8IP2 MAPK8IP3 PIN1 RAC1 RHOG SH3RF1 STUB1 TRAF6
Entrez ID		22920	4296
HPRD ID		03499	02502
Ensembl ID		ENSG00000075945	ENSG00000173327
Uniprot IDs		A0AAQ5BGI3 Q92845	Q16584
PDB IDs			5K26 5K28 6AQB 6CQ7
Enriched GO Terms of Interacting Partners?		Microtubule-based Process Protein Autophosphorylation Protein-N-terminal-alanine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity Cytoplasm Organelle Organization MAP Kinase Kinase Kinase Activity Protein N-terminal-serine Acetyltransferase Activity Cytoskeleton Organization ATPase Binding Microtubule Cytoskeleton Organization NatA Complex Microtubule Regulation Of Intracellular Estrogen Receptor Signaling Pathway Protein-N-terminal Amino-acid Acetyltransferase Activity MAPK Cascade Regulation Of Protein Serine/threonine Kinase Activity Microtubule Binding Microtubule Cytoskeleton JUN Kinase Kinase Kinase Activity Negative Regulation Of Cell Cycle Process Membraneless Organelle Assembly Positive Regulation Of Protein Serine/threonine Kinase Activity Centrosome Positive Regulation Of MAPK Cascade JNK Cascade Positive Regulation Of JUN Kinase Activity N-terminal Protein Amino Acid Acetylation Regulation Of MAPK Cascade Protein Binding Cytoskeleton Organelle Assembly Protein Kinase Activity Intracellular Signal Transduction Lamin Binding Negative Regulation Of Chromosome Organization Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Protein Phosphorylation Negative Regulation Of Cell Cycle Protein Serine Kinase Activity Angiotensin-activated Signaling Pathway Dynein Complex Binding Mitochondrial Calcium Ion Homeostasis Phosphorylation Protein Serine/threonine Kinase Activity Positive Regulation Of JNK Cascade Regulation Of Protein Kinase Activity ATP Binding Kinase Activity Regulation Of Chromosome Organization	Intracellular Signaling Cassette MAPK Cascade Intracellular Signal Transduction Regulation Of JNK Cascade Regulation Of MAPK Cascade JNK Cascade Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Postsynapse Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Positive Regulation Of Signal Transduction Protein Serine/threonine Kinase Activity Nucleotide Binding Kinesin II Complex MAP-kinase Scaffold Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Axo-dendritic Transport Protein Kinase Binding Protein Serine Kinase Activity Regulation Of Apoptotic Process Protein Kinase Activity Transport Along Microtubule Regulation Of Programmed Cell Death Signal Transduction Glutamatergic Synapse Cytoskeleton-dependent Intracellular Transport Fc-epsilon Receptor Signaling Pathway Plus-end-directed Vesicle Transport Along Microtubule Regulation Of Signal Transduction ATP Binding Microtubule-based Transport Kinase Activity Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Plus-end-directed Organelle Transport Along Microtubule Regulation Of Postsynapse Organization Cell Projection Organization CD40 Receptor Complex Anterograde Dendritic Transport JUN Kinase Binding Regulation Of Phosphorus Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of Phosphorylation Photoreceptor Connecting Cilium Kinesin Binding Kinesin Complex Establishment Of Vesicle Localization Cytoplasm
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