HOXA10 and GMNN

Number of citations of the paper that reports this interaction (PubMedID 14973489)
0

Data Source:
HPRD (in vitro)

		HOXA10	GMNN
Description		homeobox A10	geminin DNA replication inhibitor
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Transcription Repressor Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Histone Deacetylase Binding Sequence-specific Double-stranded DNA Binding	Chromatin Binding Transcription Corepressor Activity Protein Binding Histone Deacetylase Binding DNA-binding Transcription Factor Binding
	Biological Process	Skeletal System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Spermatogenesis Single Fertilization Male Gonad Development Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Regulation Of Gene Expression Embryonic Limb Morphogenesis Prostate Gland Development Response To Testosterone Response To Estrogen Positive Regulation Of Transcription By RNA Polymerase II Uterus Development	Regulation Of DNA Replication Regulation Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Animal Organ Morphogenesis Regulation Of DNA-templated DNA Replication Initiation Positive Regulation Of Chromatin Binding Negative Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Protein-containing Complex Assembly DNA Replication Preinitiation Complex Assembly Negative Regulation Of DNA-templated DNA Replication
Pathways			Assembly of the pre-replicative complex Activation of the pre-replicative complex Switching of origins to a post-replicative state
Drugs		Calcitriol
Diseases
GWAS		Dental caries ( 23259602) Hypertension ( 30487518 31879980) Mean arterial pressure ( 30487518) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Metabolite levels ( 23823483)
Interacting Genes		14 interacting genes: CREBBP EMX1 EP300 FOXO1 GMNN GNG13 HMGB1 MEIS1 PBX1 POLR3D PTPN6 SIRT2 SNAPC1 SPI1	34 interacting genes: ARNT AURKA CASP3 CDC20 CDKN1A CDKN2A CDT1 CEBPA CSNK2A1 FZR1 GLIS2 HOXA10 HOXA11 HOXA7 HOXB7 HOXC8 HOXC9 HOXD10 IMPDH1 KANK2 KAT7 LNX1 MCM6 NCF1 PHC1 PTPN11 REPIN1 RNF2 SAPCD2 SCMH1 SIX3 SMARCA4 ZNF250 ZNF439
Entrez ID		3206	51053
HPRD ID		00845	06783
Ensembl ID		ENSG00000253293	ENSG00000112312
Uniprot IDs		P31260	O75496
PDB IDs			1T6F 1UII 2LP0 2WVR 4BRY 7KLZ
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Binding Chromatin Binding Positive Regulation Of Innate Immune Response Histone H3K27 Acetyltransferase Activity Megakaryocyte Development Regulation Of Innate Immune Response Positive Regulation Of Defense Response Transcription Regulator Complex Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Nucleus Protein Acetylation Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Developmental Process Positive Regulation Of Binding Regulation Of Oligodendrocyte Progenitor Proliferation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Hemopoiesis Positive Regulation Of Immune Response RNA Polymerase II-specific DNA-binding Transcription Factor Binding Chromatin Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Regulation Of Immune System Process Damaged DNA Binding Transcription Corepressor Activity Regulation Of RNA Metabolic Process Activation Of Innate Immune Response Developmental Process Myeloid Cell Development Regulation Of Cell Differentiation Regulation Of Hemopoiesis Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Lymphocyte Differentiation STAT Family Protein Binding Regulation Of Cell Population Proliferation Lymphocyte Activation Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process	Negative Regulation Of Cell Cycle Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Cell Cycle DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Phase Transition Anterior/posterior Pattern Specification Nucleus Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regionalization DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Skeletal System Morphogenesis Regulation Of Cell Cycle Process Proximal/distal Pattern Formation Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Embryonic Skeletal System Morphogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Metabolic Process Embryonic Morphogenesis Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Chromatin Binding Regulation Of DNA-templated DNA Replication Initiation Regulation Of Mitotic Cell Cycle Phase Transition Chromatin Embryonic Organ Morphogenesis Regulation Of Mitotic Cell Cycle Nuclear Body Negative Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Developmental Process Cellular Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process
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