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CASP9 and BIRC8
Number of citations of the paper that reports this interaction (PubMedID
33961781
)
97
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
CASP9
BIRC8
Description
caspase 9
baculoviral IAP repeat containing 8
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Mitochondrion
Cytosol
Caspase Complex
Protein-containing Complex
Apoptosome
Nucleus
Cytoplasm
Molecular Function
Cysteine-type Endopeptidase Activity
Protein Binding
Enzyme Activator Activity
Peptidase Activity
Cysteine-type Peptidase Activity
Hydrolase Activity
Protein Kinase Binding
Identical Protein Binding
Ubiquitin-protein Transferase Activity
Cysteine-type Endopeptidase Inhibitor Activity
Zinc Ion Binding
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Response To Hypoxia
Kidney Development
Response To Ischemia
Proteolysis
Apoptotic Process
DNA Damage Response
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To UV
Protein Processing
Platelet Formation
Response To Cobalt Ion
Response To Estradiol
Response To Lipopolysaccharide
Glial Cell Apoptotic Process
Cellular Response To UV
Signal Transduction In Response To DNA Damage
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Fibroblast Apoptotic Process
Neuron Apoptotic Process
Protein Maturation
Cellular Response To Dexamethasone Stimulus
Response To Indole-3-methanol
Leukocyte Apoptotic Process
Response To Anesthetic
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Execution Phase Of Apoptosis
Epithelial Cell Apoptotic Process
Apoptotic Process
Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Protein Ubiquitination
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of JNK Cascade
Regulation Of Cell Cycle
Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways
Formation of apoptosome
Activation of caspases through apoptosome-mediated cleavage
SMAC (DIABLO) binds to IAPs
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
NOD1/2 Signaling Pathway
AKT phosphorylates targets in the cytosol
Caspase activation via Dependence Receptors in the absence of ligand
Constitutive Signaling by AKT1 E17K in Cancer
Regulation of the apoptosome activity
Regulation of the apoptosome activity
Drugs
Pamidronic acid
Diseases
GWAS
Alcoholic chronic pancreatitis (
28754779
)
Estimated glomerular filtration rate (
30604766
)
Glomerular filtration rate (creatinine) (
26831199
28452372
)
Glomerular filtration rate in non diabetics (creatinine) (
26831199
)
Orofacial cleft x maternal periconceptional multivitamin use interaction (1df) (
33937227
)
Orofacial cleft x maternal periconceptional multivitamin use interaction (2df) (
33937227
)
Serum metabolite levels (
33031748
)
Urate levels (
31578528
)
Urinary metabolite levels in chronic kidney disease (
31959995
)
Interacting Genes
47 interacting genes:
ABL1
AKT1
APAF1
ARNT
BCL10
BCL2L1
BIRC2
BIRC3
BIRC5
BIRC6
BIRC7
BIRC8
CAPN2
CARD8
CASP10
CASP12
CASP3
CASP7
CASP8
CYCS
DCC
DIABLO
DSP
GMEB1
GZMB
HECTD3
HIP1
HSD17B4
HSPD1
ILK
JUN
LYN
MAP2K1
MAP2K2
MAPK1
MAPK3
MSTO1
MZB1
NAIP
NLRP1
NOD1
PRKCZ
RB1
RNF2
SRF
VIM
XIAP
14 interacting genes:
CASP9
FAM107A
MAGED1
TNPO2
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2G2
UBE2K
UBE2N
UBE2V1
UBE2W
Entrez ID
842
112401
HPRD ID
03756
12525
Ensembl ID
ENSG00000132906
ENSG00000293247
Uniprot IDs
F8VVS7
P55211
PDB IDs
1JXQ
1NW9
2AR9
3D9T
3V3K
3YGS
4RHW
5JUY
5WVC
5WVE
Enriched GO Terms of Interacting Partners
?
Programmed Cell Death
Cell Death
Apoptotic Process
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Regulation Of Cell Communication
Regulation Of Signaling
Execution Phase Of Apoptosis
Positive Regulation Of Intracellular Signal Transduction
Intracellular Signal Transduction
Regulation Of Signal Transduction
Cytoplasm
Regulation Of Defense Response
Regulation Of Inflammatory Response
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Defense Response
Neuron Apoptotic Process
Pyroptotic Inflammatory Response
Bergmann Glial Cell Differentiation
Regulation Of Golgi Inheritance
Negative Regulation Of Apoptotic Process
Cytosol
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Immune System Process
Regulation Of Immune Response
Cysteine-type Endopeptidase Inhibitor Activity
Glial Cell Development
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Immune System Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Apoptotic Signaling Pathway
Regulation Of Protein Modification Process
Schwann Cell Development
Regulation Of Neuron Apoptotic Process
Trachea Formation
Response To Lipid
Regulation Of Innate Immune Response
Regulation Of Metabolic Process
Face Development
Positive Regulation Of Biosynthetic Process
Thymus Development
Ubiquitin Conjugating Enzyme Activity
Protein Polyubiquitination
Ubiquitin-protein Transferase Activity
Protein K48-linked Ubiquitination
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Post-translational Protein Modification
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Proteolysis
Macromolecule Catabolic Process
Protein Modification Process
Protein Monoubiquitination
ATP Binding
Positive Regulation Of Protein Polyubiquitination
Protein Metabolic Process
Nucleotide Binding
Transferase Activity
Positive Regulation Of Protein Ubiquitination
Regulation Of Protein Polyubiquitination
UBC13-MMS2 Complex
Catabolic Process
Positive Regulation Of Post-translational Protein Modification
Ubiquitin Conjugating Enzyme Complex
Protein K11-linked Ubiquitination
Positive Regulation Of Protein Modification Process
Regulation Of Protein Ubiquitination
Protein-containing Complex
Positive Regulation Of Protein K63-linked Ubiquitination
TORC1 Signaling
Negative Regulation Of TORC1 Signaling
Nucleus
Proteasomal Protein Catabolic Process
Protein K63-linked Ubiquitination
Regulation Of Post-translational Protein Modification
TOR Signaling
Cellular Response To Nutrient Levels
Negative Regulation Of TOR Signaling
Regulation Of Protein K63-linked Ubiquitination
Regulation Of TORC1 Signaling
Ubiquitin Ligase Complex
Protein Catabolic Process
Regulation Of Protein Modification Process
Macromolecule Metabolic Process
Cellular Response To Interferon-beta
Protein K6-linked Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of TOR Signaling
DNA Damage Response
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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