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CASP9 and BIRC8
Number of citations of the paper that reports this interaction (PMID
11390657
)
16
Data Source:
BioGRID
(two hybrid, pull down)
HPRD
(in vivo)
CASP9
BIRC8
Gene Name
caspase 9, apoptosis-related cysteine peptidase
baculoviral IAP repeat containing 8
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Mitochondrion
Cytosol
Apoptosome
Nucleus
Cytoplasm
Cytosol
Spindle Microtubule
Perinuclear Region Of Cytoplasm
Molecular Function
Cysteine-type Endopeptidase Activity
Protein Binding
Enzyme Activator Activity
Peptidase Activity
SH3 Domain Binding
Protein Kinase Binding
Protease Binding
Ubiquitin-protein Transferase Activity
Zinc Ion Binding
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Scaffold Protein Binding
Biological Process
Proteolysis
Apoptotic Process
Cellular Response To DNA Damage Stimulus
Epidermal Growth Factor Receptor Signaling Pathway
Aging
Fibroblast Growth Factor Receptor Signaling Pathway
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C
Platelet Formation
Response To Cobalt Ion
Response To Estradiol
Response To Lipopolysaccharide
Glial Cell Apoptotic Process
Cellular Response To UV
Fc-epsilon Receptor Signaling Pathway
Signal Transduction In Response To DNA Damage
Positive Regulation Of Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Innate Immune Response
Response To Antibiotic
Neurotrophin TRK Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Cellular Response To Dexamethasone Stimulus
Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Regulation Of Response To DNA Damage Stimulus
Protein Ubiquitination
Negative Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Neuron Apoptotic Process
Positive Regulation Of Canonical Wnt Signaling Pathway
Mitotic Spindle Assembly
Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Pathways
Signaling by the B Cell Receptor (BCR)
Signaling by FGFR in disease
PIP3 activates AKT signaling
SMAC binds to IAPs
SMAC-mediated dissociation of IAP:caspase complexes
Cytochrome c-mediated apoptotic response
SMAC-mediated apoptotic response
Signaling by EGFRvIII in Cancer
AKT phosphorylates targets in the cytosol
Role of DCC in regulating apoptosis
Signaling by SCF-KIT
DAP12 signaling
Downstream signaling events of B Cell Receptor (BCR)
Activation of caspases through apoptosome-mediated cleavage
Formation of apoptosome
PI3K/AKT activation
PI-3K cascade
Apoptotic factor-mediated response
NOD1/2 Signaling Pathway
PI3K events in ERBB2 signaling
Downstream signaling of activated FGFR
Programmed Cell Death
Innate Immune System
Intrinsic Pathway for Apoptosis
Signaling by PDGF
DAP12 interactions
Signalling by NGF
GAB1 signalosome
Signaling by Ligand-Responsive EGFR Variants in Cancer
NGF signalling via TRKA from the plasma membrane
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by ERBB4
Constitutive PI3K/AKT Signaling in Cancer
Role of LAT2/NTAL/LAB on calcium mobilization
PI3K events in ERBB4 signaling
Signaling by FGFR
Signaling by ERBB2
Signaling by EGFR
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
Downstream signal transduction
Fc epsilon receptor (FCERI) signaling
Signaling by EGFR in Cancer
PI3K/AKT Signaling in Cancer
Extrinsic Pathway
Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
44 interactors:
ABL1
AKT1
APAF1
BCL10
BCL2L1
BIRC2
BIRC3
BIRC5
BIRC6
BIRC7
BIRC8
CAPN2
CARD8
CASP10
CASP3
CASP7
CASP8
CYCS
DCC
DIABLO
DSP
GMEB1
GZMB
HIP1
HSD17B4
HSPD1
ILK
JUN
LYN
MAP2K1
MAP2K2
MAPK1
MAPK3
MSTO1
MZB1
NAIP
NLRP1
NOD1
PRKCZ
RB1
RNF2
SRF
VIM
XIAP
12 interactors:
CASP9
MAGED1
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2G2
UBE2K
UBE2N
UBE2V1
UBE2W
Entrez ID
842
112401
HPRD ID
03756
12525
Ensembl ID
ENSG00000132906
ENSG00000163098
Uniprot IDs
F8VVS7
P55211
Q6PIA0
Q96P09
PDB IDs
1JXQ
1NW9
2AR9
3D9T
3V3K
3YGS
1XB0
1XB1
Enriched GO Terms of Interacting Partners
?
Apoptotic Process
Programmed Cell Death
Cell Death
Death
Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Cysteine-type Endopeptidase Activity
Regulation Of Apoptotic Process
Regulation Of Endopeptidase Activity
Regulation Of Peptidase Activity
Regulation Of Cell Death
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Proteolysis
Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Catalytic Activity
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Cell Death
Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Endopeptidase Activity
Activation Of Cysteine-type Endopeptidase Activity
Positive Regulation Of Peptidase Activity
Apoptotic Signaling Pathway
Zymogen Activation
Positive Regulation Of Signal Transduction
Positive Regulation Of Metabolic Process
Positive Regulation Of Proteolysis
Toll-like Receptor Signaling Pathway
Positive Regulation Of Catalytic Activity
Protein Processing
Regulation Of Signal Transduction
Regulation Of Signaling
Intracellular Signal Transduction
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Negative Regulation Of Programmed Cell Death
Regulation Of Innate Immune Response
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Innate Immune Response
Negative Regulation Of Cell Death
Protein Polyubiquitination
Protein K48-linked Ubiquitination
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Catabolic Process
Toll-like Receptor 4 Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Proteasomal Protein Catabolic Process
Toll-like Receptor Signaling Pathway
Proteolysis
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Positive Regulation Of Innate Immune Response
Immune Response-regulating Signaling Pathway
Regulation Of Innate Immune Response
Cellular Response To Stress
Cellular Protein Modification Process
Protein K11-linked Ubiquitination
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Catabolic Process
Protein K63-linked Ubiquitination
Protein Metabolic Process
Protein Monoubiquitination
Innate Immune Response
Regulation Of Immune Response
Cellular Protein Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Positive Regulation Of Immune Response
Cellular Response To Organic Substance
Regulation Of Ubiquitin-protein Transferase Activity
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Immune Response
Regulation Of Immune System Process
Defense Response
Cellular Response To Oxygen Levels
Regulation Of Response To DNA Damage Stimulus
Cellular Response To DNA Damage Stimulus
Tagcloud
?
10mum
abeta42
abeta43
aif
carnosic
cascades
casp3
casp4
casp8
casps
concurrently
diterpene
herbs
ingestion
initiator
labiate
monomer
neurotoxicity
neurotrophic
oligomerization
oligomers
parp
phenolic
ribose
rosemary
sage
serves
sy5y
Tagcloud (Difference)
?
10mum
abeta42
abeta43
aif
carnosic
cascades
casp3
casp4
casp8
casps
concurrently
diterpene
herbs
ingestion
initiator
labiate
monomer
neurotoxicity
neurotrophic
oligomerization
oligomers
parp
phenolic
ribose
rosemary
sage
serves
sy5y
Tagcloud (Intersection)
?