CASP9 and CARD8

Number of citations of the paper that reports this interaction (PMID 11408476)
22

Data Source:
HPRD (in vivo, in vitro)

		CASP9	CARD8
Gene Name		caspase 9, apoptosis-related cysteine peptidase	caspase recruitment domain family, member 8
Image
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Cytosol Apoptosome	Nucleus Nucleoplasm Cytoplasm NLRP3 Inflammasome Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Enzyme Activator Activity Peptidase Activity SH3 Domain Binding Protein Kinase Binding	Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process NACHT Domain Binding Protein Homodimerization Activity
	Biological Process	Proteolysis Apoptotic Process Cellular Response To DNA Damage Stimulus Epidermal Growth Factor Receptor Signaling Pathway Aging Fibroblast Growth Factor Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Platelet Formation Response To Cobalt Ion Response To Estradiol Response To Lipopolysaccharide Glial Cell Apoptotic Process Cellular Response To UV Fc-epsilon Receptor Signaling Pathway Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Innate Immune Response Response To Antibiotic Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Cellular Response To Dexamethasone Stimulus Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of Response To DNA Damage Stimulus	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Interleukin-1 Beta Secretion
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling SMAC binds to IAPs SMAC-mediated dissociation of IAP:caspase complexes Cytochrome c-mediated apoptotic response SMAC-mediated apoptotic response Signaling by EGFRvIII in Cancer AKT phosphorylates targets in the cytosol Role of DCC in regulating apoptosis Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) Activation of caspases through apoptosome-mediated cleavage Formation of apoptosome PI3K/AKT activation PI-3K cascade Apoptotic factor-mediated response NOD1/2 Signaling Pathway PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Programmed Cell Death Innate Immune System Intrinsic Pathway for Apoptosis Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Extrinsic Pathway Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		44 interactors: ABL1 AKT1 APAF1 BCL10 BCL2L1 BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 BIRC8 CAPN2 CARD8 CASP10 CASP3 CASP7 CASP8 CYCS DCC DIABLO DSP GMEB1 GZMB HIP1 HSD17B4 HSPD1 ILK JUN LYN MAP2K1 MAP2K2 MAPK1 MAPK3 MSTO1 MZB1 NAIP NLRP1 NOD1 PRKCZ RB1 RNF2 SRF VIM XIAP	8 interactors: CARD16 CARD18 CASP1 CASP9 FHL2 IKBKG NLRP2 NLRP3
Entrez ID		842	22900
HPRD ID		03756	16425
Ensembl ID		ENSG00000132906	ENSG00000105483
Uniprot IDs		F8VVS7 P55211	E5RFV9 I6L9C6 Q9Y2G2
PDB IDs		1JXQ 1NW9 2AR9 3D9T 3V3K 3YGS	4IKM
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Apoptotic Process Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Cell Death Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Peptidase Activity Apoptotic Signaling Pathway Zymogen Activation Positive Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Proteolysis Toll-like Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Protein Processing Regulation Of Signal Transduction Regulation Of Signaling Intracellular Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Innate Immune Response Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Negative Regulation Of Cell Death	Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Proteolysis Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Peptidase Activity Positive Regulation Of Interleukin-1 Production Regulation Of Cellular Protein Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Protein Metabolic Process Regulation Of Interleukin-1 Beta Production Regulation Of Catalytic Activity Positive Regulation Of Proteolysis Positive Regulation Of Cytokine Secretion Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cytokine Production Zymogen Activation Apoptotic Process Programmed Cell Death Interleukin-1 Beta Production Cell Death Death Regulation Of Cytokine Secretion Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cytokine Production Positive Regulation Of Protein Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Defense Response Positive Regulation Of Protein Secretion Positive Regulation Of Cell Death Positive Regulation Of Cellular Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Other Organism Positive Regulation Of Catalytic Activity Protein Processing Response To Biotic Stimulus Innate Immune Response Regulation Of Metabolic Process
Tagcloud ?		10mum abeta42 abeta43 aif carnosic cascades casp3 casp4 casp8 casps concurrently diterpene herbs ingestion initiator labiate monomer neurotoxicity neurotrophic oligomerization oligomers parp phenolic ribose rosemary sage serves sy5y	ancient archaea autoproteolysis autoproteolytic deteriorated extend fam171 fiind gpcr gpcrs gps hfs hlt lrr nacht nlrp1 nucleoporin98 nup98 occluden origination polycystic precedes pyd searches subdomain unc5c upa zonula zu5
Tagcloud (Difference) ?		10mum abeta42 abeta43 aif carnosic cascades casp3 casp4 casp8 casps concurrently diterpene herbs ingestion initiator labiate monomer neurotoxicity neurotrophic oligomerization oligomers parp phenolic ribose rosemary sage serves sy5y	ancient archaea autoproteolysis autoproteolytic deteriorated extend fam171 fiind gpcr gpcrs gps hfs hlt lrr nacht nlrp1 nucleoporin98 nup98 occluden origination polycystic precedes pyd searches subdomain unc5c upa zonula zu5
Tagcloud (Intersection) ?