CASP9 and NAIP

Number of citations of the paper that reports this interaction (PMID 15280366)
17

Data Source:
BioGRID (far western blotting)
HPRD (in vivo)

		CASP9	NAIP
Gene Name		caspase 9, apoptosis-related cysteine peptidase	NLR family, apoptosis inhibitory protein
Image
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Cytosol Apoptosome	Nucleus Cytoplasm Spindle Microtubule Basolateral Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Enzyme Activator Activity Peptidase Activity SH3 Domain Binding Protein Kinase Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding
	Biological Process	Proteolysis Apoptotic Process Cellular Response To DNA Damage Stimulus Epidermal Growth Factor Receptor Signaling Pathway Aging Fibroblast Growth Factor Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Platelet Formation Response To Cobalt Ion Response To Estradiol Response To Lipopolysaccharide Glial Cell Apoptotic Process Cellular Response To UV Fc-epsilon Receptor Signaling Pathway Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Innate Immune Response Response To Antibiotic Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Cellular Response To Dexamethasone Stimulus Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of Response To DNA Damage Stimulus	Inflammatory Response Nervous System Development Regulation Of Signal Transduction Protein Ubiquitination Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Mitotic Spindle Assembly Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling SMAC binds to IAPs SMAC-mediated dissociation of IAP:caspase complexes Cytochrome c-mediated apoptotic response SMAC-mediated apoptotic response Signaling by EGFRvIII in Cancer AKT phosphorylates targets in the cytosol Role of DCC in regulating apoptosis Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) Activation of caspases through apoptosome-mediated cleavage Formation of apoptosome PI3K/AKT activation PI-3K cascade Apoptotic factor-mediated response NOD1/2 Signaling Pathway PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Programmed Cell Death Innate Immune System Intrinsic Pathway for Apoptosis Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Extrinsic Pathway Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		44 interactors: ABL1 AKT1 APAF1 BCL10 BCL2L1 BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 BIRC8 CAPN2 CARD8 CASP10 CASP3 CASP7 CASP8 CYCS DCC DIABLO DSP GMEB1 GZMB HIP1 HSD17B4 HSPD1 ILK JUN LYN MAP2K1 MAP2K2 MAPK1 MAPK3 MSTO1 MZB1 NAIP NLRP1 NOD1 PRKCZ RB1 RNF2 SRF VIM XIAP	3 interactors: CASP9 HPCA MAP3K7
Entrez ID		842	4671
HPRD ID		03756	09049
Ensembl ID		ENSG00000132906	ENSG00000249437
Uniprot IDs		F8VVS7 P55211	B7ZLE8 E7EQW0 Q13075
PDB IDs		1JXQ 1NW9 2AR9 3D9T 3V3K 3YGS	2VM5
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Apoptotic Process Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Cell Death Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Peptidase Activity Apoptotic Signaling Pathway Zymogen Activation Positive Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Proteolysis Toll-like Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Protein Processing Regulation Of Signal Transduction Regulation Of Signaling Intracellular Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Innate Immune Response Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Negative Regulation Of Cell Death	Fc-epsilon Receptor Signaling Pathway Fc Receptor Signaling Pathway Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Glial Cell Apoptotic Process Immune Response-regulating Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Response To Cobalt Ion Cellular Response To Growth Factor Stimulus I-kappaB Phosphorylation Negative Regulation Of Necroptotic Process Response To Growth Factor Negative Regulation Of Necrotic Cell Death Regulation Of Necroptotic Process Positive Regulation Of T Cell Cytokine Production Platelet Formation Platelet Morphogenesis Regulation Of Necrotic Cell Death Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of T Cell Cytokine Production Innate Immune Response Activation Of NF-kappaB-inducing Kinase Activity Cellular Response To Dexamethasone Stimulus Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Response To Dexamethasone Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Interleukin-2 Production Apoptotic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway NIK/NF-kappaB Signaling Programmed Cell Death Regulation Of NIK/NF-kappaB Signaling System Development Cell Death Anatomical Structure Formation Involved In Morphogenesis Histone H3 Acetylation Death Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Glucocorticoid Stimulus Toll-like Receptor 5 Signaling Pathway Cellular Response To Corticosteroid Stimulus Toll-like Receptor 10 Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Response To Antibiotic Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway
Tagcloud ?		10mum abeta42 abeta43 aif carnosic cascades casp3 casp4 casp8 casps concurrently diterpene herbs ingestion initiator labiate monomer neurotoxicity neurotrophic oligomerization oligomers parp phenolic ribose rosemary sage serves sy5y	5q13 bacs bacterium ccnb1 chosen contig copy flanking hope inherited intricate legionella lgn1 map1b mapped maps muscular p1s pathogenicity pneumophila recessively simpler sma smas smn subcloning syntenic uncharacterized yac
Tagcloud (Difference) ?		10mum abeta42 abeta43 aif carnosic cascades casp3 casp4 casp8 casps concurrently diterpene herbs ingestion initiator labiate monomer neurotoxicity neurotrophic oligomerization oligomers parp phenolic ribose rosemary sage serves sy5y	5q13 bacs bacterium ccnb1 chosen contig copy flanking hope inherited intricate legionella lgn1 map1b mapped maps muscular p1s pathogenicity pneumophila recessively simpler sma smas smn subcloning syntenic uncharacterized yac
Tagcloud (Intersection) ?