ACADS

Name	acyl-CoA dehydrogenase short chain
Structure
Novel Interactors	1 novel interactors: APAF1
Interactors	1 interactors: IRF7
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Matrix
	Molecular Function	Acyl-CoA Dehydrogenase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Short-chain Fatty Acyl-CoA Dehydrogenase Activity Flavin Adenine Dinucleotide Binding
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase Butyrate Catabolic Process
Pathways	Beta oxidation of hexanoyl-CoA to butanoyl-CoA Beta oxidation of butanoyl-CoA to acetyl-CoA
Drugs	NADH Acetoacetyl-CoA Flavin adenine dinucleotide
Diseases	Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP)
GWAS	Allergic rhinitis ( 30013184 ) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Mean corpuscular volume ( 29403010 ) Metabolic traits ( 21886157 ) Metabolite levels ( 31628463 20037589 ) Red blood cell count ( 27863252 ) Red cell distribution width ( 27863252 ) Refractive error ( 32231278 ) Schizophrenia ( 30285260 ) Serum metabolite concentrations in chronic kidney disease ( 29545352 33838163 ) Serum metabolite levels ( 23093944 33031748 ) Serum metabolite ratios in chronic kidney disease ( 29545352 ) Smoking status (ever vs never smokers) ( 30643258 ) Urinary metabolite levels in chronic kidney disease ( 31959995 ) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995 ) Urinary metabolites (H-NMR features) ( 24586186 )
Entrez ID	35
HPRD ID	06053
Ensembl ID	ENSG00000122971
Uniprot IDs	B4DUH1 E5KSD5 E9PE82 P16219
PDB IDs	2VIG 7Y0A 7Y0B 8SGS
GO Terms Enriched among Interactors ?	Response To G1 DNA Damage Checkpoint Signaling Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Establishment Of Viral Latency Apoptosome Response To DNA Damage Checkpoint Signaling Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway MDA-5 Signaling Pathway Negative Regulation Of Macrophage Apoptotic Process Regulation Of Apoptotic DNA Fragmentation Cysteine-type Endopeptidase Activator Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Cardiac Muscle Cell Apoptotic Process Striated Muscle Cell Apoptotic Process Muscle Cell Apoptotic Process Positive Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Monocyte Differentiation Negative Regulation Of Myeloid Cell Apoptotic Process Positive Regulation Of Interferon-alpha Production Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Myeloid Cell Apoptotic Process ADP Binding Immunoglobulin Mediated Immune Response Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Interferon-beta Production Regulation Of Type I Interferon-mediated Signaling Pathway B Cell Mediated Immunity Type I Interferon-mediated Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Heat Shock Protein Binding Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Leukocyte Apoptotic Process Regulation Of Interferon-beta Production Positive Regulation Of Signal Transduction Forebrain Development Cellular Response To Stress Response To Transforming Growth Factor Beta Interferon-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Positive Regulation Of Cell Communication Tube Closure Intracellular Signal Transduction Positive Regulation Of Signaling Neural Tube Closure Positive Regulation Of Type I Interferon Production Cis-regulatory Region Sequence-specific DNA Binding Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Cytoplasmic Pattern Recognition Receptor Signaling Pathway Neuron Apoptotic Process